Basic Science and Clinical Introduction 2

The course is compulsory in The Study Programme in Medicine, 360 credits andconstitutes semester 4.

Institute of Biomedicine
Institute of Medicine

Passed grade Basic science and early profession contact 2, 30 credits andfurthermore all courses placed before semester 2, according to The Study Programme in Medicine's programme curriculum, should be approved. Furthermore, a Pass grade onthe following course components on course Basic science and clinical introduction 1 is required: laboratory session (bioinformatics exercise), seminar (Hallmarksof Cancer I) and half of the clinical placement.

The course contains genetics, pathology, consultation knowledge pharmacology andlevel examination. Throughout the semester, aims related to professional development isalso included.
The first part of the semester includes the adaptation at injury and repair of cells andtissues, inflammation and origin and development of diseases with an emphasis oncancer. The importance of genetic factors at disease development and genetic methodsof analysis is included, as well as how different mechanisms interact at disease processes.

The students are introduced to handling by referrals and receive basic knowledge of howthe health care is organised. Legislation and ethical aspects that regulate handling ofautopsies and biological material are treated, and ethical issues at genetic diagnostics arediscussed.
This is followed by a level examination that summarises semester 1 to 3.

Furthermore, the course include education in consultation knowledge and patientapproach with an increased complexity compared to previous semester. Here,knowledge is also included about how violence, migration, other life circumstances andenvironmental factors influence health. The students will also reflect on theirprofessional development.

The final part of the course include basic pharmacology for different pharmaceuticalgroups and pharmacokinetic principles. Both drug effects on the environment andpharmaceutical studies is concerned as well as how new drugs are developed.

On successful completion of the course the student will be able to:

Knowledge and understanding

• account for how cell biology and the micro- and macroscopic structure of tissues interact to create and maintain the function of organ systems
• give an account of the medical disease concept and on a general level describe the origin and development of diseases current genetic, inflammatory, degenerative and cancer diseases
• on a general level, give an account for the mechanisms behind molecular, genetic,cellular and morphological changes at disease
• explain how disease processes influence the structure and function of tissues
• explain how different genetic methods of analysis are used at diagnostics and describe these weakness and strengths
• on a general level, describe sample and referral management in health care
• give an account of the organisation of the health care at the national, regional and municipal level
• describe legislation regulating the rights of patients and their relatives in connection with post-mortem examinations and the handling of biobank material
• discuss the treatment of patients of different origins and account for the technique of communication through an interpreter
• discuss treatment and treatment of people in crisis
• discuss the gender perspective in the consultation
• discuss treatment of people with abuses
• on a general level, give an account of forms and occurrence of violence andconsequences of this from a national and global perspective
• give an account of the influence of the migration on the health
• give an account of basic pharmacological principles and concepts
• give an account of what is known respect the action mode for important drugs and pharmaceutical groups
• give an account of field of use and important adverse drug reactions for important drugs and pharmaceutical groups
• give an account of the uptake, distribution and decomposition of drug and fo rdifferent preparation forms and administration route
• describe important stages from synthesis of drugs to approval
• give an account of the different transmission pathways of drug to the environmentand how risks for both environment - and human health can be assessed and limited

Competence and skills

• analyse cases and situations on the basis of collected knowledge in professional development
• interpret and analyse disease processes based on genetic information and microscopical images
• integrate information from molecular, genetic and morphological analyses when diagnosing diseases
• present and discuss scientific information relevant to cancer diseases
• design referrals on the basis of pathological issues under supervision
• apply a person-centred working method to acquire a structured medical history and carry out a clinical status under supervision
• identify risk factors for future disease of a patient under supervision
• on a general level explain clinical findings for the patient and separate between the normal and the sickly
• compile and in writing document a patient meeting in the patient journal together with supervisor
• describe how common drugs can interact at the pharmacodynamic or pharmacokinetic level
• demonstrate ability to find and interpret information in digital sources for pharmaceutical information
• discuss strengths and weaknesses in clinical pharmaceutical studies
• carry out s-cardiopulmonary resuscitation in a simulated environment
• carry out subcutaneous and intramuscular injection

Judgement and approach

• discuss pathogenic mechanisms at disease development
• discuss and evaluate ethical aspects at genetic diagnostics and guidance
• reflect on ethical aspects when handling the dead body and of human tissue
• demonstrate a professional attitude vis-à-vis patients, the relative and co-workers
• reflect on their own learning and their professional development and identify personal aims for continued development
• reflect on the different living environments of people and how health and diseaseare influenced by circumstances
• reflect on equal use of drugs based on ethical principles of priority in health care

The teaching activities will consist of:

• lectures
• seminars
• group work
• peer-learning
• laboratory sessions
• role play
• skills training (pathological preparations)
• clinical placement
• group exercise
• self-studies

During the clinical placement, the student trains their proficiency to carry out for physicians central professional activities and may continuous feedback on these components according to the model for "Entrustable Professional Activities" (EPA) and participate in multi-disciplinary conferences (MDK).

Language of instruction: Swedish
Some parts may be given in English.

The course is examined through the following components:

• seminar: genetics/ethics (1 credit)
• seminar: chronic inflammation (1 credit)
• seminar: Hallmarks of cancer II (1 credit)
• laboratory session: computer-based laboratory session genetics (0.5 credits)
• laboratory sessions: pharmacology (1 credit)
• web-tests: pathology (3 credits)
• web-tests: pharmacology (2 credits)
• written assignments and seminars: professional development (1 credit)
• written assignment and oral reflection on the basis of own professionaldevelopment: professional development (0.5 credits)
• group assignments: pharmacology (2 credits)
• simulation exercises (1 credit)
• in-depth consultation knowledge (1 hp)
• clinical placement 1 (1 credit)
• clinical placement 2 (1 credit)
• practical examination: consultation knowledge (1 credit)
• group assignment and written examination: integrated examination in basic science and professional development (level examination) (1.5 credits)
• written examination (medically genetics and clinical pathology) (6.5 credits)
• written examination (consultation knowledge, professional development and pharmacology (4 credits)

For approved clinical placement, attendance and completed components are required according to the examination portfolio for Entrustable Professional Activities (EPA).

All compulsory elements must be completed in order to pass the course and, if missed,should be retaken as soon as possible by agreement with the course coordinator.

The number of clinical placement (VFU) opportunities is limited to two (2) occasions.

If a student has received a recommendation from the University of Gothenburg for special support in learning when compatible with the learning outcomes of the courseand provided that unreasonable resources are not required, the examiner may decide to allow the student adjusted conditions for exam or alternative form of assessment.

The examiner may, with immediate effect, suspend a student from his/her clinical placement or equivalent if the student shows a deficiencies in knowledge, skills or attitudes to the degree that there is significant risk for self-injury or physically or mentally injury of another person or that patient safety or the patients' confidence in healthcare is at risk. When the clinical placement is interrupted in this way it means that the student has failed the current course component, and that he/she may not continue the same clinical placement at a later stage. The reason for the interruption should be documented and an individual plan be established that states which activities and knowledge checks are required before the student can be offered a new clinical placement. A student who fails clinical placement has the possibility to retake the course once more.

If a student who has been failed twice for the same examination element wishes to change examiner before the next examination session, such a request is to be granted unless there are specific reasons to the contrary (Chapter 6 Section 22 HF).

If a student has received a certificate of disability study support from the University of Gothenburg with a recommendation of adapted examination and/or adapted forms of assessment, an examiner may decide, if this is consistent with the course’s intended learning outcomes and provided that no unreasonable resources would be needed, to grant the student adapted examination and/or adapted forms of assessment.

If a course has been discontinued or undergone major changes, the student must be offered at least two examination sessions in addition to ordinary examination sessions. These sessions are to be spread over a period of at least one year but no more than two years after the course has been discontinued/changed. The same applies to placement and internship (VFU) except that this is restricted to only one further examination session.

If a student has been notified that they fulfil the requirements for being a student at Riksidrottsuniversitetet (RIU student), to combine elite sports activities with studies, the examiner is entitled to decide on adaptation of examinations if this is done in accordance with the Local rules regarding RIU students at the University of Gothenburg.

The grading scale comprises: Pass (G) and Fail (U).

Course evaluation takes place during an on-going course in the form of a Course Board, where the elected representatives of the course discuss with the course management representatives The protocol from the course board will be published on the university's learning platform. Written course evaluation takes place after the first half of the course and again after the end of the course with the help of a course evaluation survey. A compilation of the course evaluation is published in the virtual learning environment and forms the basis for development of the course.

The result and any changes in the course structure must be communicated to both the students who completed the evaluation and to the students who will start the course.

Elements of distance/web-based teaching can occur in the course which assume access to a computer, web camera and connection.

Clinical placements may be carried out outside the Gothenburg region and may involve travel costs for students.

At clinical placements, certain units may require the student to be able to present extractfrom the criminal record. It is therefore important that the student always has a valid extract that can be shown upon request. For some activities, ID checks of students may also occur.

At clinical placements, the Västra Götaland region and Region Halland's regulations for professional secrecy and confidentiality apply.

At clinical placements, the hospital hygienic routines of respective activities are followed.