Immune dysregulation is a key feature of many diseases, e.g. autoimmunity and cancer, and even though the thymus is of vital importance for immune regulation, therapeutic tools to target thymic function are lacking. The groups main research focus is clinical and experimental studies of tolerance mechanisms in the thymus.
Since knowledge gaps exist regarding basic mechanisms of thymic function, a broad translational approach is applied in which clinical, epidemiological and experimental, in vitro and in vivo, studies are combined. In the projects, we are utilizing a combination of a unique access to human thymus, experimental front-line methodology, epidemiological studies, animal models and a well-defined patient material to address a central scientific and clinical problem.