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Studies to elucidate the binding capacities of Enterotoxigenic Escherichia coli (ETEC) colonisation factor fimbriae to human glycans
Research project
Short description
In this project we are glyco-engineering CHO-K1 cell lines to study human small intestinal glycan/ETEC CF fimbriae binding interactions. In parallel to this work, we are also using molecular docking to identify novel glycan binding sites on ETEC CF fimbriae, as well as aid our understanding of why these intestinal/ETEC CF interactions may occur. The subsequent findings from these studies could lead to a better molecular understanding of ETEC pathogenesis, aiding in the development of vaccines and/or non-antibiotic therapeutics.