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Studies to elucidate the binding capacities of Enterotoxigenic Escherichia coli (ETEC) colonisation factor fimbriae to human glycans

Research project
Active research
Project owner
Prof. Ann-Mari Svennerholm (PI) and Dr Lynda Mottram, Dep. of Microbiology and Immunology in collaboration with Prof. Jan Holgersson, Dep. of Clinical Chemistry and Transfusion Medicine and Sonali Chavan (PhD student), Dep. of Chemistry and Molecular Biol

Swedish Research Council

Short description

In this project we are glyco-engineering CHO-K1 cell lines to study human small intestinal glycan/ETEC CF fimbriae binding interactions. In parallel to this work, we are also using molecular docking to identify novel glycan binding sites on ETEC CF fimbriae, as well as aid our understanding of why these intestinal/ETEC CF interactions may occur. The subsequent findings from these studies could lead to a better molecular understanding of ETEC pathogenesis, aiding in the development of vaccines and/or non-antibiotic therapeutics.