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Xiaogang Feng
Researcher
Department of Rheumatology and Inflammation ResearchAbout Xiaogang Feng
Biography
I am an immunologist with more than ten years of experience in gastrointestinal immunology and epithelial biology. Since 2025, I have been a Researcher at the University of Gothenburg. I completed my Ph.D. in Infectious Medicine at the Karolinska Institute (KI), where I investigated how intestinal helminths modulate systemic immunity and disrupt lymph node function. I subsequently carried out postdoctoral training at the University of Zurich (UZH), focusing on type 2 immunity and identifying IL-17RB as a critical tuft cell–intrinsic regulator of the tuft cell–ILC2 circuit.
Research
Tuft cells in the small and large intestine are rare, chemosensory epithelial cells derived from intestinal stem cells. They are best known for their role in detecting helminths and initiating type 2 immune responses. My research aims to define how tuft cells sense pathogens, orchestrate mucosal immunity, and contribute to epithelial homeostasis and repair.
Funding
Sahlgrenska Academy (University of Gothenburg)
Åke Wiberg Foundation
Methods and Approaches
Our work integrates a range of experimental systems and advanced technologies, including: Transgenic mouse models, Intestinal and colonic 3D organoid cultures, High-resolution 3D imaging, Flow cytometry and spectral cytometry, Single-cell RNA sequencing and computational immunology
Collaborations
Dr. Mattias Svensson Group (University of Gothenburg)
Dr. Yunlong Yang Group (Fudan University)
Dr. Kristina Eriksson Group (University of Gothenburg)
Dr. Jiyu Guan Group (Jilin University)
Dr. Sherwin Chan Group (Karolinska Institute)
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Tuft cell IL-17RB restrains IL-25 bioavailability and reveals context-dependent ILC2
hypoproliferation
Xiaogang Feng, T. Andersson, P. Fluchter, J. Gschwend, I. Berest, J. L. Muff, A. Lechner, A. Gondrand, P. Westermann, N. Brander, D. Carchidi, J. C. De Tenorio, T. Pan, U. Boehm, C. S. N. Klose, D. Artis, C. B. Messner, T. Leinders-Zufall, F. Zufall, C. Schneider
Nature Immunology - 2025 -
Tuft cells in the intestine, immunity and
beyond
Xiaogang Feng, P. Fluchter, J. C. De Tenorio, C. Schneider
Nature Reviews Gastroenterology & Hepatology - 2024 -
Notch Signaling Regulates the Chondrogenic Potential of Both Articular Chondrocytes and Their Progenitors During
Expansion
A. D. Kurenkova, Lei Li, A. P. Usanova, Xiaogang Feng, B. Y. Zhou, A. A. Nedorubov, A. V. Lychagin, Andrei S. Chagin
Stem Cells - 2023 -
Intestinal helminth infection transforms the CD4(+) T cell composition of the
skin
C. H. Classon, M. Li, A. L. Clavero, J. Ma, Xiaogang Feng, C. A. Tibbitt, J. M. Stark, R. Cardoso, E. Ringqvist, L. Boon, E. J. Villablanca, A. G. Rothfuchs, L. Eidsmo, J. M. Coquet, S. Nylen
Mucosal Immunology - 2022 -
Differential sensitivity of inflammatory macrophages and alternatively activated macrophages to
ferroptosis
F. Piattini, M. Matsushita, J. Muri, P. Bretscher, Xiaogang Feng, S. Freigang, J. Dalli, C. Schneider, M. Kopf
European Journal of Immunology - 2021 -
Interrogating the Small Intestine Tuft Cell-ILC2 Circuit Using In Vivo
Manipulations
C. E. O'Leary, Xiaogang Feng, V. S. Cortez, R. M. Locksley, C. Schneider
current protocols - 2021 -
Alveolar macrophages rely on GM-CSF from alveolar epithelial type 2 cells before and after
birth
J. Gschwend, S. P. M. Sherman, F. Ridder, Xiaogang Feng, H. E. Liang, R. M. Locksley, B. Becher, C. Schneider
Journal of Experimental Medicine (JEM) - 2021 -
Fat Wasting Is Damaging: Role of Adipose Tissue in Cancer-Associated
Cachexia
X. Sun, Xiaogang Feng, X. Wu, Y. Lu, K. Chen, Y. Ye
Frontiers in Cell and Developmental Biology - 2020 -
Single-Cell RNA Sequencing of the T Helper Cell Response to House Dust Mites Defines a Distinct Gene Expression Signature in Airway Th2
Cells
C. A. Tibbitt, J. M. Stark, L. Martens, J. Ma, J. E. Mold, K. Deswarte, G. Oliynyk, Xiaogang Feng, B. N. Lambrecht, P. De Bleser, S. Nylen, H. Hammad, M. Arsenian Henriksson, Y. Saeys, J. M. Coquet
Immunity - 2019 -
Intestinal nematode infection exacerbates experimental visceral
leishmaniasis
C. Classon, Xiaogang Feng, L. Eidsmo, S. Nylen
Parasite immunology (Print) - 2019 -
Atrophy of skin-draining lymph nodes predisposes for impaired immune responses to secondary infection in mice with chronic intestinal nematode
infection
Xiaogang Feng, C. Classon, G. Teran, Y. Yang, L. Li, S. Chan, U. Ribacke, A. G. Rothfuchs, J. M. Coquet, S. Nylen
PLoS Pathogens - 2018 -
PPAR-gamma promotes type 2 immune responses in allergy and nematode
infection
T. Chen, C. A. Tibbitt, Xiaogang Feng, J. M. Stark, L. Rohrbeck, L. Rausch, S. K. Sedimbi, M. C. I. Karlsson, B. N. Lambrecht, G. B. Karlsson Hedestam, R. W. Hendriks, B. J. Chambers, S. Nylen, J. M. Coquet
Science Immunology - 2017 -
Chronic Gastrointestinal Nematode Infection Mutes Immune Responses to Mycobacterial Infection Distal to the
Gut
K. Obieglo, Xiaogang Feng, V. P. Bollampalli, I. Dellacasa-Lindberg, C. Classon, M. Osterblad, H. Helmby, J. P. Hewitson, R. M. Maizels, A. Gigliotti Rothfuchs, S. Nylen
Journal of Immunology - 2016 -
BCG Skin Infection Triggers IL-1R-MyD88-Dependent Migration of EpCAMlow CD11bhigh Skin Dendritic cells to Draining Lymph Node During CD4+ T-Cell
Priming
V. P. Bollampalli, L. Harumi Yamashiro, Xiaogang Feng, D. Bierschenk, Y. Gao, H. Blom, B. Henriques-Normark, S. Nylen, A. G. Rothfuchs
PLoS Pathogens - 2015