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Pekka Jaako
Researcher
Department of Microbiology and Immunology-
eIF6 rebinding dynamically couples ribosome maturation and
translation.
Pekka Jaako, Alexandre Faille, Shengjiang Tan, Chi C Wong, Norberto Escudero-Urquijo, Pablo Castro-Hartmann, Penny Wright, Christine Hilcenko, David J Adams, Alan J Warren
Nature communications - 2022 -
EFL1 mutations impair eIF6 release to cause Shwachman-Diamond
syndrome.
Shengjiang Tan, Laëtitia Kermasson, Angela Hoslin, Pekka Jaako, Alexandre Faille, Abraham Acevedo-Arozena, Etienne Lengline, Dana Ranta, Maryline Poirée, Odile Fenneteau, Hubert Ducou le Pointe, Stefano Fumagalli, Blandine Beaupain, Patrick Nitschké, Christine Bôle-Feysot, Jean-Pierre de Villartay, Christine Bellanné-Chantelot, Jean Donadieu, Caroline Kannengiesser, Alan J Warren, Patrick Revy
Blood - 2019 -
Induction of the 5S RNP-Mdm2-p53 ribosomal stress pathway delays the initiation but fails to eradicate established murine acute myeloid
leukemia.
Pekka Jaako, A Ugale, M Wahlestedt, T Velasco-Hernandez, J Cammenga, M S Lindström, D Bryder
Leukemia - 2017 -
Lentiviral Vectors with Cellular Promoters Correct Anemia and Lethal Bone Marrow Failure in a Mouse Model for Diamond-Blackfan
Anemia.
Shubhranshu Debnath, Pekka Jaako, Kavitha Siva, Michael Rothe, Jun Chen, Maria Dahl, H Bobby Gaspar, Johan Flygare, Axel Schambach, Stefan Karlsson
Molecular therapy : the journal of the American Society of Gene Therapy - 2017 -
Disruption of the 5S RNP-Mdm2 interaction significantly improves the erythroid defect in a mouse model for Diamond-Blackfan
anemia.
Pekka Jaako, S Debnath, K Olsson, Y Zhang, J Flygare, M S Lindström, D Bryder, S Karlsson
Leukemia - 2015 -
Glucocorticoids improve erythroid progenitor maintenance and dampen Trp53 response in a mouse model of Diamond-Blackfan
anaemia.
Sara E Sjögren, Kavitha Siva, Shamit Soneji, Amee J George, Marcus Winkler, Pekka Jaako, Marcin Wlodarski, Stefan Karlsson, Ross D Hannan, Johan Flygare
British journal of haematology - 2015 -
Gene therapy cures the anemia and lethal bone marrow failure in a mouse model of RPS19-deficient Diamond-Blackfan
anemia.
Pekka Jaako, Shubhranshu Debnath, Karin Olsson, Ute Modlich, Michael Rothe, Axel Schambach, Johan Flygare, Stefan Karlsson
Haematologica - 2014 -
Hematopoietic stem cells are intrinsically protected against MLL-ENL-mediated
transformation.
Amol Ugale, Gudmundur L Norddahl, Martin Wahlestedt, Petter Säwén, Pekka Jaako, Cornelis Jan Pronk, Shamit Soneji, Jörg Cammenga, David Bryder
Cell reports - 2014 -
SPARC is dispensable for murine hematopoiesis, despite its suspected pathophysiological role in 5q-myelodysplastic
syndrome.
K Siva, Pekka Jaako, K Miharada, E Rörby, M Ehinger, G Karlsson, S Karlsson
Leukemia - 2012 -
Dietary L-leucine improves the anemia in a mouse model for Diamond-Blackfan
anemia.
Pekka Jaako, Shubhranshu Debnath, Karin Olsson, David Bryder, Johan Flygare, Stefan Karlsson
Blood - 2012 -
Mice with ribosomal protein S19 deficiency develop bone marrow failure and symptoms like patients with Diamond-Blackfan
anemia.
Pekka Jaako, Johan Flygare, Karin Olsson, Ronan Quere, Mats Ehinger, Adrianna Henson, Steven Ellis, Axel Schambach, Christopher Baum, Johan Richter, Jonas Larsson, David Bryder, Stefan Karlsson
Blood - 2011 -
Canonical BMP signaling is dispensable for hematopoietic stem cell function in both adult and fetal liver hematopoiesis, but essential to preserve colon
architecture.
Sofie Singbrant, Göran Karlsson, Mats Ehinger, Karin Olsson, Pekka Jaako, Ken-Ichi Miharada, Matthias Stadtfeld, Thomas Graf, Stefan Karlsson
Blood - 2010