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Karl Persson
Researcher
Department of Biological & Environmental SciencesAbout Karl Persson
My research focuses on yeasts, from their evolutionary history to their potential to contribute to more sustainable agriculture. I am particularly interested in how microbial biodiversity can be translated into practical solutions.
I received my PhD from the University of Gothenburg in 2022 with a thesis on evolution and evolvability in the model yeast Saccharomyces cerevisiae. During my doctoral studies, I investigated how genetic changes shape adaptation over short and long evolutionary timescales, in close collaboration with international research groups in evolutionary genomics. This work provided me with extensive experience in experimental evolution, high-throughput phenotyping, and genomics.
Toward the end of my PhD, I became involved in a side project together with researchers from Nigeria who were working with a large collection of wild yeast isolates. This project marked a turning point. Moving from a well-studied model organism to a diverse range of non-conventional yeasts opened a new research direction for me: bioprospecting and functional characterization of natural yeast biodiversity.
As a postdoctoral researcher at Chalmers University of Technology, I continued working with non-model yeasts and their metabolic and biotechnological potential. In parallel, we initiated a citizen science project in which more than one hundred Swedish beekeepers contributed honey samples. The result was a unique collection of approximately 2,500 yeast isolates from Swedish honey, a resource that now forms the foundation of my current research.
Today, I am a researcher at the Department of Biological and Environmental Sciences (BioEnv), University of Gothenburg, where I lead the Formas-funded project BioHive. The project investigates how yeasts that naturally occur in the beehive can be used for biological control of honeybee pathogens. By combining microbial ecology, genomics, and experimental biology, we develop sustainable alternatives to antibiotics and chemical treatments in apiculture. The overall aim is to improve honeybee health while contributing to a more sustainable and resilient food system.
Read more about previous projects and interviews:
- Swedish beekeepers contributed honey samples to a study on yeasts in honey.
- Our work on wild yeast strains from Nigeria.
- During the Gothenburg Science Festival, primary school students visited our lab to learn about yeast and create agar art.
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Reproductive Isolation due to Divergent Ecological Selection Is Accompanied by Vast Genomic Instability in Experimentally Evolved Yeast
Populations
Devin P. Bendixsen, Ciaran Gilchrist, Chloé Haberkorn, Karl Persson, Cecilia Geijer, Jonas Warringer, Rike Stelkens
Molecular Ecology - 2025 -
Evolutionary engineering and molecular characterization of an antimycin A-resistant Saccharomyces cerevisiae strain: the key role of pleiotropic drug resistance
(PDR1)
Alican Topaloğlu, Can Holyavkin, Ömer Esen, Ogün Morkoç, Karl Persson, Cecilia Geijer, Zeynep Petek Çakar
FEMS Yeast Research - 2025 -
Lactose-assimilating yeasts with high fatty acid accumulation uncovered by untargeted
bioprospecting
Karl Persson, Vanessa O. Onyema, Ijeoma Princess Nwafor, Kameshwara V. R. Peri, Chika Otti, Priscilla Nnaemeka, Chioma Onyishi, Sylvia Okoye, Anene Moneke, Onyetugo Amadi, Jonas Warringer, Cecilia Geijer
APPLIED AND ENVIRONMENTAL MICROBIOLOGY - 2025 -
A unique metabolic gene cluster regulates lactose and galactose metabolism in the yeast Candida
intermedia
Kameshwara V.R. Peri, Le Yuan, Fábio Faria Oliveira, Karl Persson, Hanna D. Alalam, Lisbeth Olsson, Johan Larsbrink, Eduard J. Kerkhoven, Cecilia Geijer
Applied and Environmental Microbiology - 2024 -
Adaptation of the yeast gene knockout collection is near-perfectly predicted by fitness and diminishing return
epistasis.
Karl Persson, Simon Stenberg, Markus J. Tamás, Jonas Warringer
G3 (Bethesda, Md.) - 2022 -
Genetically controlled mtDNA deletions prevent ROS damage by arresting oxidative
phosphorylation.
Simon Stenberg, Jing Li, Arne B Gjuvsland, Karl Persson, Erik Demitz-Helin, Carles González Peña, Jia-Xing Yue, Ciaran Gilchrist, Timmy Ärengård, Payam Ghiaci, Lisa Larsson-Berglund, Martin Zackrisson, Silvana Smits, Johan Hallin, Johanna L Höög, Mikael Molin, Gianni Liti, Stig W Omholt, Jonas Warringer
eLife - 2022 -
Domestication reprogrammed the budding yeast life
cycle
M. De Chiara, B. P. Barré, Karl Persson, A. Irizar, C. Vischioni, S. Khaiwal, Simon Stenberg, Onyetugo Chioma Amadi, G. Žun, K. Doberšek, C. Taccioli, J. Schacherer, U. Petrovič, Jonas Warringer, G. Liti
Nature Ecology and Evolution - 2022 -
The Genetics of Adaptation and Evolvability in
Yeast
Karl Persson
2022 -
Aborting meiosis allows recombination in sterile diploid yeast
hybrids
S. Mozzachiodi, L. Tattini, A. Llored, A. Irizar, N. Skofljanc, M. D'Angiolo, M. De Chiara, B. P. Barre, J. X. Yue, A. Lutazi, S. Loeillet, R. Laureau, S. Marsit, Simon Stenberg, B. Albaud, Karl Persson, J. L. Legras, S. Dequin, Jonas Warringer, A. Nicolas, G. Liti
Nature Communications - 2021 -
Intragenic repeat expansion in the cell wall protein gene HPF1 controls yeast chronological
aging
B. P. Barré, J. Hallin, J. X. Yue, Karl Persson, E. Mikhalev, A. Irizar, S. Holt, D. Thompson, M. Molin, Jonas Warringer, G. Liti
Genome research - 2020 -
A yeast living ancestor reveals the origin of genomic
introgressions
M. D'Angiolo, M. De Chiara, J. X. Yue, A. Irizar, Simon Stenberg, Karl Persson, A. Llored, B. Barre, J. Schacherer, R. Marangoni, E. Gilson, Jonas Warringer, G. Liti
Nature - 2020 -
Shared Molecular Targets Confer Resistance over Short and Long Evolutionary
Timescales
J. Li, I. Vázquez-García, Karl Persson, A. González, J. X. Yue, B. Barré, M. N. Hall, A. Long, Jonas Warringer, V. Mustonen, G. Liti
Molecular biology and evolution - 2019 -
Expression of NADH-oxidases enhances ethylene productivity in Saccharomyces cerevisiae expressing the bacterial
EFE
N. Johansson, Karl Persson, Joakim Norbeck, C. Larsson
Biotechnology and Bioprocess Engineering - 2017 -
Contrasting evolutionary genome dynamics between domesticated and wild
yeasts
J. X. Yue, J. Li, L. Aigrain, J. Hallin, Karl Persson, K. Oliver, A. Bergstrom, P. Coupland, Jonas Warringer, M. C. Lagomarsino, G. Fischer, R. Durbin, G. Liti
Nature Genetics - 2017 -
Comparative sequence analysis and mutagenesis of Ethylene Forming Enzyme (EFE) 2-oxoglutarate/Fe(II)-dependent dioxygenase
homologs
Nina Johansson, Karl Persson, Christer Larsson, Joakim Norbeck
BMC Biochemistry - 2014 -
Ethylene production in relation to nitrogen metabolism in Saccharomyces
cerevisiae
Nina Johansson, Karl Persson, P. Quehl, Joakim Norbeck, Christer Larsson
Fems Yeast Research - 2014