Alpha Camera Imaging
This newly developed technique by Tom Bäck makes it possible to image and pin-point the location of the alpha particles emitted by for example 211At and 213Bi in in vivo samples, with a resolution of ~20 µm.
This technique has been used when in radiobiological studies when investigationg the appearence of double-strand breaks in irradiated cell nuclei. Breaks are visualized by labeling of gamma-H2AX foci, emerging within minutes at the site of DNA breaks.
This technique is used on a regular basis when for example investigating the presence of microscopic tumors in hematoxylin/eosin coloured tissue samples in our therapy studies.
Scanning Electron Microscopy (SEM)
This technique has been used in some studies when for example investigating the relationship between the estimated absorbed dose to differently sized small tumors and the therapeutic efficacy.
Transmission Electron Microscopy (TEM)
This technique has been used occasionally when investigating how the ovarian tumor cells for example are attached to the peritoneal lining during studies of the therapetic efficacy.
Various standard nuclear-medicine imaging techniqes have been utilized in for example the phase I study to image the localization of radioactivity in the body.