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- Giorgia Ortolani
Giorgia Ortolani
Postdoctor
Department of Chemistry & Molecular BiologyAbout Giorgia Ortolani
My research focuses on the structural characterization and dynamics of photoactivated membrane proteins, particularly within the Rhodopsin family. To investigate these systems, I employ advanced biophysical techniques such as cryo-crystallography, time-resolved serial crystallography, and time-resolved X-ray solution scattering. Additionally, I have experience in studying soluble mitochondrial proteins using single-particle cryo-electron microscopy (cryo-EM) to elucidate their structural properties.
Building on this expertise, I am now expanding my research to explore viral proteins with the goal of developing novel antiviral therapeutics. By integrating structural biology methods (including time-resolved crystallography and cryo-EM) with computational drug discovery approaches, I aim to uncover key mechanistic insights into viral protein function and identify potential drug targets. This interdisciplinary strategy bridges experimental and computational techniques to advance our understanding of viral pathogenesis and facilitate rational drug design.
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Structural basis for the prolonged photocycle of sensory rhodopsin II revealed by serial synchrotron
crystallography
Robert Bosman, Giorgia Ortolani, Swagatha Ghosh, Daniel James, Per Norder, Greger Hammarin, Tinna Björg Úlfarsdóttir, Lucija Ostojic, Tobias Weinert, Florian Dworkowski, Takashi Tomizaki, Jorg Standfuss, Gisela Brändén, Richard Neutze
NATURE COMMUNICATIONS - 2025 -
Structural effects of high laser power densities on an early bacteriorhodopsin photocycle
intermediate
Quentin Bertrand, Przemyslaw Nogly, Eriko Nango, Demet Kekilli, Georgii Khusainov, Antonia Furrer, Daniel James, Florian Dworkowski, Petr Skopintsev, Sandra Mous, Isabelle Martiel, Per Börjesson, Giorgia Ortolani, Chia-Ying Huang, Michal Kepa, Dmitry Ozerov, Steffen Bruenle, Valerie Panneels, Tomoyuki Tanaka, Rie Tanaka, Kensuke Tono, Shigeki Owada, Philip J. M. Johnson, Karol Nass, Gregor Knopp, Claudio Cirelli, Christopher Milne, Gebhard Schertler, So Iwata, Richard Neutze, Tobias Weinert, Joerg Standfuss
NATURE COMMUNICATIONS - 2024 -
Time-resolved serial crystallography to track the dynamics of carbon monoxide in the active site of cytochrome c
oxidase
Cecilia Safari, Swagatha Ghosh, Rebecka Andersson, Jonatan Johannesson, Petra Båth, Owens Uwangue, Peter Dahl, Doris Zoric, Emil Sandelin, Adams Vallejos, Eriko Nango, Rie Tanaka, Robert Bosman, Per Börjesson, Elin Dunevall, Greger Hammarin, Giorgia Ortolani, Matthijs R Panman, Tomoyuki Tanaka, Ayumi Yamashita, Toshi Arima, Michihiro Sugahara, Mamoru Suzuki, Tetsuya Masuda, Hanae Takeda, Raika Yamagiwa, Kazumasa Oda, Masahiro Fukuda, Takehiko Tosha, Hisashi Naitow, Shigeki Owada, Kensuke Tono, Osamu Nureki, So Iwata, Richard Neutze, Gisela Brändén
Science advances - 2023 -
Ultrafast structural changes direct the first molecular events of
vision
T. Gruhl, T. Weinert, M. J. Rodrigues, C. J. Milne, Giorgia Ortolani, K. Nass, E. Nango, S. Sen, P. J. M. Johnson, C. Cirelli, A. Furrer, S. Mous, P. Skopintsev, D. James, F. Dworkowski, Petra Båth, D. Kekilli, D. Ozerov, R. Tanaka, H. Glover, C. Bacellar, S. Brunle, C. M. Casadei, A. D. Diethelm, D. Gashi, G. Gotthard, R. Guixa-Gonzalez, Y. Joti, V. Kabanova, G. Knopp, E. Lesca, P. K. Y. Ma, I. Martiel, J. Mnhle, S. Owada, F. Pamula, Daniel Sarabi, O. Tejero, C. J. Tsai, N. Varma, A. Wach, S. Boutet, K. Tono, P. Nogly, X. Deupi, S. Iwata, Richard Neutze, J. Standfuss, G. Schertler, V. Panneels
Nature - 2023 -
Lipidic cubic phase serial femtosecond crystallography structure of a photosynthetic reaction
centre
Petra Båth, Analia Banacore, Per Börjesson, Robert Bosman, Cecilia Wickstrand, Cecilia Safari, Robert Dods, Swagatha Ghosh, Peter Dahl, Giorgia Ortolani, Tinna Bjorg Ulfarsdottir, Greger Hammarin, Maria-Jose Garcia-Bonete, Adams Vallejos, Lucija Ostojic, Petra Edlund, Johanna Barbara Linse, Rebecka Andersson, E. Nango, S. Owada, R. Tanaka, K. Tono, Y. Joti, O. Nureki, F. J. Luo, D. James, K. Nass, P. J. M. Johnson, G. Knopp, D. Ozerov, C. Cirelli, C. Milne, S. Iwata, Gisela Brändén, Richard Neutze
Acta Crystallographica Section D-Structural Biology - 2022 -
Time-resolved X-ray diffraction and solution scattering studies of Sensory Rhodopsin II in isolation and in complex with its
transducer
Giorgia Ortolani
2022