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Jan Holmgren
Seniorforskare
Avd för mikrobiologi och immunologi-
Heterologous prime-boost immunization combining parenteral and mucosal routes with different adjuvants mounts long-lived CD4+ T cell responses in
lungs
Ranmali Kavishna, Thorunn Olafsdottir, Siggeir Brynjolfsson, Dennis Christensen, Tobias Gustafsson-Hedberg, Peter Andersen, Manuela Terrinoni, Jan Holmgren, Ali M Harandi
Frontiers in Immunology - 2025 -
Potential for a Combined Oral Inactivated Whole-Cell Vaccine Against ETEC and Shigella: Preclinical Studies Supporting
Feasibility
Manuela Terrinoni, Jan Holmgren, Kevin Ross Turbyfill, Lillian van de Verg, Nicole Maier, Richard Walker
VACCINES - 2025 -
A double-blind, randomised phase III clinical trial to evaluate safety, immunogenicity, non-inferiority & lot to lot consistency of single component oral cholera vaccine BBV131 (Hillchol®) in comparison to
Shanchol™
Krishna Mohan Vadrevu, Abhishek Chavan, Amit Chawla, B. S. Chakravarthy, Chandramani Singh, Sagar Redkar, Savita Verma, Sriharsha Yandapally, M. Suma Priya, Vasant Khalatkar, Vishal Tripathi, Sagar Vishal Tripathi, Brunda Ganneru, Siddharth Reddy, Bhargav Reddy, Jan Holmgren, Badri Patnaik, Sai D. Prasad, Raches Ella
VACCINE - 2025 -
Protection by natural cholera against later episodes of cholera over 10 years of follow-up in Matlab, Bangladesh: a retrospective cohort
study
Masuma Hoque, Deok Ryun Kim, Faisal Ahmmed, Md Taufiqul Islam, Justin Im, Birkneh Tilahun Tadesse, Sophie Kang, Farhana Khanam, Fahima Chowdhury, Tasnuva Ahmed, Md Golam Firoj, Asma Binte Aziz, Suman Kanungo, Ashraful Islam Khan, Md Alfazal Khan, Jooah Lee, Gideok Pak, Florian Marks, Jerome H. Kim, Andrew Azman, Jan Holmgren, Firdausi Qadri, Khalequ Zaman, John D. Clemens
LANCET MICROBE - 2025 -
Safety, Tolerability, and Immunogenicity of the InvaplexAR-Detox Shigella Vaccine Co-Administered with the dmLT Adjuvant in Dutch and Zambian Adults: Study Protocol for a Multi-Center, Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation Phase Ia/b Clinical
Trial
Geert V. T. Roozen, Nsofwa Sukwa, Masuzyo Chirwa, Jessica A. White, Marcus Estrada, Nicole Maier, Kevin R. Turbyfill, Renee M. Laird, Akamol E. Suvarnapunya, Aicha Sayeh, Flavia D'Alessio, Candice Marion, Laura Pattacini, Marie-Astrid Hoogerwerf, Rajagopal Murugan, Manuela Terrinoni, Jan Holmgren, Sodiomon B. Sirima, Sophie Houard, Michelo Simuyandi, Meta Roestenberg
VACCINES - 2025 -
Cholera
Vaccines
John D. Clemens, Sachin N. Desai, Firdausi Qadri, G. Balakrish Nair, Jan Holmgren
Plotkin's Vaccines, Eighth Edition - 2023 -
A thermostable, dry formulation inactivated Hikojima whole cell/cholera toxin B subunit oral cholera
vaccine
Manuela Terrinoni, Stefan Nordqvist, Madeleine Löfstrand, Frida Nilsson, Susanne Källgård, T. Sharma, Michael Lebens, Jan Holmgren
Vaccine - 2023 -
Safety and immunogenicity of ETVAX (R), an oral inactivated vaccine against enterotoxigenic Escherichia coli diarrhoea: a double-blinded, randomized, placebo-controlled trial amongst Finnish travellers to Benin, West
Africa
A. Kantele, M. Riekkinen, T. S. Jokiranta, S. H. Pakkanen, J. P. Pietila, A. Patjas, M. Eriksson, T. Khawaja, P. Klemets, K. Marttinen, H. Siikamaki, Anna Lundgren, Jan Holmgren, A. Lissmats, N. Carlin, Ann-Mari Svennerholm
Journal of Travel Medicine - 2023 -
Evaluating improved inactivated oral cholera vaccines for use in ending endemic cholera by 2030: opportunities and
challenges
J. Deen, Jan Holmgren, J. D. Clemens
The Lancet Infectious Diseases - 2022 -
An Update on Cholera Immunity and Current and Future Cholera
Vaccines
Jan Holmgren
Tropical Medicine and Infectious Disease - 2021 -
A phase I/II study to evaluate safety, tolerability and immunogenicity of Hillchol®, an inactivated single Hikojima strain based oral cholera vaccine, in a sequentially age descending population in
Bangladesh
F. Chowdhury, K. Ali Syed, A. Akter, T. Rahman Bhuiyan, I. Tauheed, F. Khaton, R. Biswas, J. Ferdous, H. Al Banna, A. G. Ross, N. Mc Millan, T. Sharma, V. Kanchan, A. Pal Singh, D. Gill, Michael Lebens, Stefan Nordqvist, Jan Holmgren, J. D. Clemens, F. Qadri
Vaccine - 2021 -
Immune responses against oxidized LDL as possible targets for prevention of atherosclerosis in systemic lupus
erythematosus
I. Yao Mattisson, S. Rattik, H. Björkbacka, I. Ljungcrantz, Manuela Terrinoni, Michael Lebens, Jan Holmgren, G. N. Fredrikson, B. Gullstrand, A. A. Bengtsson, J. Nilsson, M. Wigren
Vascular Pharmacology - 2021 -
Development of Hillchol (R), a low-cost inactivated single strain Hikojima oral cholera
vaccine
T. Sharma, N. Joshi, A. K. Mandyal, Stefan Nordqvist, Michael Lebens, V. Kanchan, Madeleine Löfstrand, Frida Jeverstam, M. M. Ahasan, I. Khan, M. Karim, H. Muktadir, A. Muktadir, D. Gill, Jan Holmgren
Vaccine - 2020 -
Cholera immunity and development and use of oral cholera vaccines for disease
control
F. Qadri, J. D. Clemens, Jan Holmgren
Mucosal Vaccines. Innovation for Preventing Infectious Diseases. Hiroshi Kiyono and David W. Pascual (red.) - 2020 -
Alpha-galactosylceramide enhances mucosal immunity to oral whole-cell cholera
vaccines
C. J. H. Davitt, S. Longet, A. Albutti, V. Aversa, Stefan Nordqvist, B. Hackett, C. P. McEntee, M. Rosa, I. S. Coulter, Michael Lebens, Joshua Tobias, Jan Holmgren, E. C. Lavelle
Mucosal Immunology - 2019 -
Requirement for Cyclic AMP/Protein Kinase A-Dependent Canonical NF kappa B Signaling in the Adjuvant Action of Cholera Toxin and Its Non-toxic Derivative
mmCT
Manuela Terrinoni, Jan Holmgren, Michael Lebens, Maximilian Larena
Frontiers in Immunology - 2019 -
Proteomic analysis of cholera toxin adjuvant-stimulated human monocytes identifies Thrombospondin-1 and Integrin-beta 1 as strongly upregulated molecules involved in adjuvant
activity
Manuela Terrinoni, Jan Holmgren, Michael Lebens, Maximilian Larena
Scientific Reports - 2019 -
An oral alpha-galactosylceramide adjuvanted Helicobacter pylori vaccine induces protective IL-1R-and IL-17R-dependent Th1
responses
S. Longet, A. Abautret-Daly, C. J. H. Davitt, C. P. McEntee, V. Aversa, M. Rosa, I. S. Coulter, Jan Holmgren, Sukanya Raghavan, E. C. Lavelle
Npj Vaccines - 2019 -
Adjuvants Enhance the Induction of Germinal Center and Antibody Secreting Cells in Spleen and Their Persistence in Bone Marrow of Neonatal
Mice
A. A. A. Pind, M. Dubik, S. Thorsdottir, A. Meinke, A. M. Harandi, Jan Holmgren, G. Del Giudice, I. Jonsdottir, S. P. Bjarnarson
Frontiers in Immunology - 2019 -
A Novel Nonantibiotic, lgt-Based Selection System for Stable Maintenance of Expression Vectors in Escherichia coli and Vibrio
cholerae
Manuela Terrinoni, Stefan Nordqvist, Susanne Källgård, Jan Holmgren, Michael Lebens
Applied and Environmental Microbiology - 2018 -
B cells treated with CTB-p210 acquire a regulatory phenotype in vitro and reduce atherosclerosis in apolipoprotein E deficient
mice
S. Rattik, P. T. Mantani, I. Y. Mattisson, I. Ljungcrantz, L. Sundius, H. Bjorkbacka, Manuela Terrinoni, Michael Lebens, Jan Holmgren, J. Nilsson, M. Wigren, G. N. Fredrikson
Vascular Pharmacology - 2018 -
Preclinical immunogenicity and protective efficacy of an oral Helicobacter pylori inactivated whole cell vaccine and multiple mutant cholera toxin: A novel and non-toxic mucosal
adjuvant
Jan Holmgren, Stefan Nordqvist, Margareta Blomquist, Frida Jeverstam, Michael Lebens, Sukanya Raghavan
Vaccine - 2018 -
Lack of Fc Gamma Receptor IIIA Promotes Rather than Suppresses Humoral and Cellular Immune Responses after Mucosal or Parenteral Immunization with Antigen and
Adjuvants
Jia-Bin Sun, Jan Holmgren, Xianghua Zhou
Scandinavian Journal of Immunology - 2017 -
Cholera
John D. Clemens, G. Balakrish Nair, Tahmeed Ahmed, Firdausi Qadri, Jan Holmgren
The Lancet - 2017 -
Deficiency in calcium-binding protein S100A4 impairs the adjuvant action of cholera
toxin
Jiabin Sun, Jan Holmgren, Maximilian Larena, Manuela Terrinoni, Yu Fang, A. R. Bresnick, Xianghua Zhou
Frontiers in Immunology - 2017 -
Thermostability of the coating, antigen and immunostimulator in an adjuvanted oral capsule vaccine
formulation
S. Longet, V. Aversa, D. O'Donnell, Joshua Tobias, M. Rosa, Jan Holmgren, I. S. Coulter, E. C. Lavelle
International Journal of Pharmaceutics - 2017 -
Surface expression of Helicobacter pylori HpaA adhesion antigen on Vibrio cholerae, enhanced by co-expressed enterotoxigenic Escherichia coli fimbrial
antigens
Joshua Tobias, Michael Lebens, S. N. Wai, Jan Holmgren, Ann-Mari Svennerholm
Microbial Pathogenesis - 2017 -
Construction and preclinical evaluation of mmCT, a novel mutant cholera toxin adjuvant that can be efficiently produced in genetically manipulated Vibrio
cholerae
Michael Lebens, Manuela Terrinoni, Stefan L. Karlsson, Maximilian Larena, Tobias Gustafsson-Hedberg, Susanne Källgård, Erik Nygren, Jan Holmgren
Vaccine - 2016 -
Preparation and preclinical evaluation of a freeze-dried formulation of a novel combined multivalent whole-cell/B-subunit oral vaccine against enterotoxigenic Escherichia coli
diarrhea
Annika Borde, Annelie Ekman, A. Larsson, N. Carlin, Jan Holmgren, Joshua Tobias
European Journal of Pharmaceutics and Biopharmaceutics - 2016 -
Retrospective Analysis of Serotype Switching of Vibrio cholerae O1 in a Cholera Endemic Region Shows It Is a Non-random
Process
Stefan L. Karlsson, N. Thomson, A. Mutreja, T. Connor, D. Sur, M. Ali, J. Clemens, G. Dougan, Jan Holmgren, Michael Lebens
Plos Neglected Tropical Diseases - 2016 -
A novel adjuvanted capsule based strategy for oral vaccination against infectious diarrhoeal
pathogens
C. J. H. Davitt, E. A. McNeela, S. Longet, Joshua Tobias, V. Aversa, C. P. McEntee, M. Rosa, I. S. Coulter, Jan Holmgren, E. C. Lavelle
Journal of Controlled Release - 2016 -
Helicobacter pylori Infection of the Gastric
Mucosa
Sukanya Raghavan, Jan Holmgren, Ann-Mari Svennerholm
Mucosal Immunology: Fourth Edition - 2015 -
Vaccines against Bacterial Enteric
Infections
Jan Holmgren, M. M. Levine
Mucosal Immunology: Fourth Edition - 2015 -
Cholera toxin, and the related nontoxic adjuvants mmCT and dmLT, promote human Th17 responses via cyclic AMP-protein kinase A and inflammasome-dependent IL-1
signaling
Maximilian Larena, Jan Holmgren, Michael Lebens, Manuela Terrinoni, Anna Lundgren
Journal of Immunology - 2015 -
Vaccines against enteric infections for the developing
world
Cecil Czerkinsky, Jan Holmgren
Philosophical Transactions of the Royal Society B-Biological Sciences - 2015 -
When, How, and Where can Oral Cholera Vaccines be Used to Interrupt Cholera
Outbreaks?
John Clemens, Jan Holmgren
Cholera Outbreaks - 2014 -
Development of Stable Vibrio cholerae O1 Hikojima Type Vaccine Strains Co-Expressing the Inaba and Ogawa Lipopolysaccharide
Antigens
Stefan Karlsson, Elisabeth Ax, Erik Nygren, Susanne Källgård, Margareta Blomquist, Annelie Ekman, John Benktander, Jan Holmgren, Michael Lebens
Plos One - 2014 -
Vibriocidal Antibody Responses to a Bivalent Killed Whole-Cell Oral Cholera Vaccine in a Phase III Trial in Kolkata,
India
S. Kanungo, A. L. Lopez, M. Ali, B. Manna, D. R. Kim, T. Mahapatra, Jan Holmgren, M. S. Dhingra, T. F. Weirzba, G. B. Nair, S. K. Bhattacharya, J. D. Clemens, D. Sur
Plos One - 2014 -
Expression of Cholera Toxin by El Tor Vibrio cholerae in Shallow Culture Growth
Conditions
Mayra Cobaxin, Haydee Martinez, Guadalupe Ayala, Jan Holmgren, Åsa Sjöling, Joaquin Sanchez
Microbial Pathogenesis - 2014 -
5 year efficacy of a bivalent killed whole-cell oral cholera vaccine in Kolkata, India: A cluster-randomised, double-blind, placebo-controlled
trial
S. K. Bhattacharya, D. Sur, M. Ali, S. Kanungo, Y. A. You, B. Manna, B. Sah, S. K. Niyogi, J. K. Park, B. Sarkar, M. K. Puri, D. R. Kim, J. L. Deen, Jan Holmgren, R. Carbis, M. S. Dhingra, A. Donner, G. B. Nair, A. L. Lopez, T. F. Wierzba, J. D. Clemens
Lancet. Infectious Diseases - 2013 -
Important Role for Fc gamma RIIB on B Lymphocytes for Mucosal Antigen-Induced Tolerance and Foxp3(+) Regulatory T
Cells
Jia-Bin Sun, Zou Xiang, K. G. C. Smith, Jan Holmgren
Journal of Immunology - 2013 -
Anti-bacterial and anti-toxic immunity induced by a killed whole-cell-cholera toxin B subunit cholera vaccine is essential for protection against lethal bacterial infection in mouse pulmonary cholera
model.
S S Kang, J S Yang, K W Kim, Jan Holmgren, Cecil Czerkinsky, S H Han, C-H Yun
Mucosal immunology - 2013 -
Development and preclinical evaluation of safety and immunogenicity of an oral ETEC vaccine containing inactivated E. coli bacteria overexpressing colonization factors CFA/I, CS3, CS5 and CS6 combined with a hybrid LT/CT B subunit antigen, administered alone and together with dmLT
adjuvant.
Jan Holmgren, L Bourgeois, N Carlin, J Clements, B Gustafsson, Anna Lundgren, Erik Nygren, Joshua Tobias, R Walker, Ann-Mari Svennerholm
Vaccine - 2013 -
A double mutant heat-labile toxin from Escherichia coli, LT(R192G/L211A), is an effective mucosal adjuvant for vaccination against Helicobacter pylori
infection.
Louise Sjökvist Ottsjö, Carl-Fredrik Flach, Jan Holmgren, John Clements, Sukanya Raghavan
Infection and immunity - 2013 -
Clinical trial to evaluate safety and immunogenicity of an oral inactivated enterotoxigenic Escherichia coli prototype vaccine containing CFA/I overexpressing bacteria and recombinantly produced LTB/CTB hybrid
protein.
Anna Lundgren, Susannah Leach, Joshua Tobias, N Carlin, B Gustafsson, Marianne Jertborn, L Bourgeois, R Walker, Jan Holmgren, Ann-Mari Svennerholm
Vaccine - 2013 -
Vaccines against mucosal
infections.
Ann-Mari Svennerholm, Jan Holmgren
Current Opinion in Immunology - 2012 -
Mucosal Delivery Routes for Optimal Immunization: Targeting Immunity to the Right
Tissues
Cecil Czerkinsky, Jan Holmgren
Mucosal Vaccines: Modern Concepts, Strategies, and Challenges - 2012 -
Evidence for several waves of global transmission in the seventh cholera
pandemic.
Ankur Mutreja, DW Kim, Nicholas Thomson, TR Connor, JH Lee, S Kariuki, NJ Croucher, SY Choi, SR Harris, Michael Lebens, SK Niyogi, EJ Kim, T Ramamurthy, J Chun, JL Wood, JD Clemens, Cecil Czerkinsky, GB Nair, Jan Holmgren, Julian Parkhill, Gordon Dougan
Nature - 2012 -
Effect of protein release rates from tablet formulations on the immune response after sublingual
immunization
Annika Borde, Annelie Ekman, Jan Holmgren, Anette Larsson
European Journal of Pharmaceutical Sciences - 2012 -
A case for control of cholera in Africa by
vaccination.
Jan Holmgren
The Lancet infectious diseases - 2012
Fler publikationer
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