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Jakob Bellman
Forskare
Sektionen för fysiologiOm Jakob Bellman
Forskargrupp
The gravitostat - a novel system regulating body fat homeostasis
Forskningsintresse
Fysiologin bakom reglering av födointag och kroppsvikt. Forskning på olika nivåer med preklinisk, translationell och klinisk forskning.
Pågående forskning
Translationella och kliniska forskningsstudier som undersöker en ny potentiell homeostatisk mekanism för reglering av kroppsfett – Gravitostaten. Forskningen utreder samband mellan ökad belastning på benen och kroppsvikten.
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Short-term effects of weight-loading on heart rate variability in obese
adults
Jakob Bellman, Per-Anders Jansson, John-Olov Jansson, Claes Ohlsson, Lennart Bergfeldt
PHYSIOLOGICAL REPORTS - 2026 -
The effect of increased weight loading on body weight is partly dependent on Piezo1 in osteoblast-lineage cells and TrkA
signaling.
Daniel Hägg, Lei Li, Alec T Beeve, Erica L Scheller, Jakob Bellman, Fredrik Anesten, Jovana Zlatkovic, Adrià Dalmau Gasull, Ferran Font, Sofia Moverare Skrtic, John-Olov Jansson, Claes Ohlsson
Scientific reports - 2026 -
Increased weight-bearing load reduces biological body weight while sodium and water balances are
unaffected
Jovana Zlatkovic, Jakob Bellman, Daniel Hägg, Mathilda Magnusson, Claes Ohlsson, Gerald DiBona, Fredrik Anesten, John-Olov Jansson
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY - 2025 -
Increased weight-load improves body composition by reducing fat mass and waist circumference, and by increasing lean mass in participants with obesity: a single-centre randomised controlled
trial
Jakob Bellman, Klaas Westerterp, Loek Wouters, Marit Johannesson, Niklas Lundqvist, Joel Kullberg, Christel Larsson, Mikael Gustafsson, Stefan Pettersson, Jonatan Fridolfsson, Daniel Arvidsson, Mats Börjesson, Dan Curiac, John-Olov Jansson, Per-Anders Jansson, Claes Ohlsson
BMC MEDICINE - 2025 -
Osteoblast-lineage cells regulate metabolism and fat
mass
Daniel Hägg, Per-Anders Jansson, Jakob Bellman, John-Olov Jansson, Claes Ohlsson
Current Opinion in Endocrine and Metabolic Research - 2023 -
The dual hypothesis of homeostatic body weight regulation, including gravity-dependent and leptin-dependent
actions.
John-Olov Jansson, Fredrik Anesten, Daniel Hägg, Jovana Zlatowic, Suzanne L. Dickson, Per-Anders Jansson, Erik Schéle, Jakob Bellman, Claes Ohlsson
Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 2023 -
Solving the conundrum of intra-specific variation in metabolic rate: A multidisciplinary conceptual and methodological toolkit New technical developments are opening the door to an understanding of why metabolic rate varies among individual animals of a
species
N. B. Metcalfe, Jakob Bellman, P. Bize, P. U. Blier, A. Crespel, N. J. Dawson, R. E. Dunn, L. G. Halsey, W. R. Hood, M. Hopkins, S. S. Killen, D. McLennan, L. E. Nadler, J. J. H. Nati, M. J. Noakes, T. Norin, S. E. Ozanne, M. Peaker, A. K. Pettersen, A. Przybylska-Piech, A. Rathery, C. Recapet, E. Rodriguez, K. Salin, A. Stier, E. Thoral, K. R. Westerterp, M. S. Westerterp-Plantenga, M. S. Wojciechowski, P. Monaghan
Bioessays - 2023 -
Reduction of body weight by increased loading is associated with activation of norepinephrine neurones in the medial nucleus of the solitary
tract.
Jovana Zlatkovic, Adrià Dalmau Gasull, Daniel Hägg, Ferran Font Gironès, Jakob Bellman, Björn Meister, Vilborg Palsdottir, Johan Ruud, Claes Ohlsson, Suzanne L. Dickson, Fredrik Anesten, John-Olov Jansson
Journal of neuroendocrinology - 2023 -
A Body Weight Sensor Regulates Prepubertal Growth via the Somatotropic Axis in Male
Rats
John-Olov Jansson, Adria Dalmau Gasull, Erik Schele, Suzanne L. Dickson, Vilborg Palsdottir, Anders Palmquist, Ferran Font Gironès, Jakob Bellman, Fredrik Anesten, Daniel Hägg, Claes Ohlsson
Endocrinology - 2021 -
Increased weight loading reduces body weight and body fat in obese subjects – A proof of concept randomized clinical
trial
Claes Ohlsson, Edwin Gidestrand, Jakob Bellman, Christel Larsson, Vilborg Palsdottir, Daniel Hägg, Per-Anders Jansson, John-Olov Jansson
EClinicalMedicine - 2020 -
Glucagon-Like Peptide-1-, but not Growth and Differentiation Factor 15-, Receptor Activation Increases the Number of Interleukin-6-Expressing Cells in the External Lateral Parabrachial
Nucleus
Fredrik Anesten, Devesh Mishra, Adria Dalmau Gasull, Linda Engström Ruud, Jakob Bellman, Vilborg Palsdottir, F Zhang, S. Trapp, Karolina P Skibicka, Matti Poutanen, John-Olov Jansson
Neuroendocrinology - 2019 -
Interactions Between the Gravitostat and the Fibroblast Growth Factor System for the Regulation of Body
Weight
Vilborg Palsdottir, Sara H Windahl, Daniel Hägg, Hanna Keantar, Jakob Bellman, A. Buchanan, T. J. Vaughan, Daniel Lindén, John-Olov Jansson, Claes Ohlsson
Endocrinology - 2019 -
The Gravitostat Regulates Fat Mass in Obese Male Mice While Leptin Regulates Fat Mass in Lean Male
Mice
Claes Ohlsson, Daniel Hägg, Fredrik Hammarhjelm, Adria Gasull, Jakob Bellman, Sara H Windahl, Vilborg Palsdottir, John-Olov Jansson
Endocrinology - 2018 -
Body weight homeostat that regulates fat mass independently of leptin in rats and
mice.
John-Olov Jansson, Vilborg Palsdottir, Daniel Hägg, Erik Schéle, Suzanne L. Dickson, Fredrik Anesten, Tina Bake, Mikael Montelius, Jakob Bellman, Maria E I Johansson, Roger D Cone, Daniel J Drucker, Jianyao Wu, Biljana Aleksic, Anna E Törnqvist, Klara Sjögren, Jan-Åke Gustafsson, Sara H Windahl, Claes Ohlsson
Proceedings of the National Academy of Sciences of the United States of America - 2018