Johanna Höög
Universitetslektor
Institutionen för kemi ochOm Johanna Höög
Min forskningsgrupp fokuserar på cellulär elektronmikroskopi, speciellt kryoelektrontomografi. Med denna teknik gör man högupplösta 3D bilder av celler. Mitt forskningsfokus är på hur eukaryotiska flageller är uppbyggda, speciellt mänskliga spermiesvansar. För att läsa populärvetenskapligt om vår senaste artikel klicka här: www.iflscience.com/health-and-medicine/scientists-discover-a-new-struct…. Vi forskar även på cellers åldrande i samarbete med Thomas Nyström.
Jag har gjort hela min utbildning utomlands (Tyskland, USA och England). Jag doktorerade på EMBL i Heidelberg, Tyskland 2007. Docent i Cell Biologi 2018.
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Nuclear envelope budding and its cellular
functions
Katharina Keuenhof, V. Kohler, Filomena Bröskamp, Dimitra Panagaki, S. D. Speese, S. Buttner, Johanna L Höög
Nucleus - 2023 -
Using reporters of different misfolded proteins reveals differential strategies in processing protein
aggregates.
Kara Schneider, Doryaneh Ahmadpour, Katharina Keuenhof, Anna-Maria Eisele-Bürger, Lisa Larsson Berglund, Frederik Eisele, Roja Babazadeh, Johanna L Höög, Thomas Nyström, Per O Widlund
Journal of Biological Chemistry - 2022 -
Genetically controlled mtDNA deletions prevent ROS damage by arresting oxidative
phosphorylation.
Simon Stenberg, Jing Li, Arne B Gjuvsland, Karl Persson, Erik Demitz-Helin, Carles González Peña, Jia-Xing Yue, Ciaran Gilchrist, Timmy Ärengård, Payam Ghiaci, Lisa Larsson-Berglund, Martin Zackrisson, Silvana Smits, Johan Hallin, Johanna L Höög, Mikael Molin, Gianni Liti, Stig W Omholt, Jonas Warringer
eLife - 2022 -
Sphingosine 1-phosphate mediates adiponectin receptor signaling essential for lipid homeostasis and
embryogenesis.
Mario Ruiz, Ranjan Devkota, Dimitra Panagaki, Per-Olof Bergh, Delaney Kaper, Marcus Henricsson, Ali Nik, Kasparas Petkevicius, Johanna L Höög, Mohammad Bohlooly-Y, Peter Carlsson, Jan Borén, Marc Pilon
Nature communications - 2022 -
SPACA9 is a lumenal protein of human ciliary singlet and doublet
microtubules
Miao Gui, Jacob Croft, Davide Zabeo, Vajradhar Acharya, Justin M Kollman, Thomas Burgoyne, Johanna L Höög, Alan Brown
Proceedings of the National Academy of Sciences of the United States of America - 2022 -
Inhibition of MAP4K4 signaling initiates metabolic reprogramming to protect hepatocytes from lipotoxic
damage
Sumit Kumar Anand, Mara Caputo, Ying Xia, Emma Andersson, Emmelie Cansby, Sima Kumari, Marcus Henricsson, R. Porosk, Katharina Keuenhof, Johanna L Höög, Syam Nair, Hanns-Ulrich Marschall, M. Bluher, Margit Mahlapuu
Journal of Lipid Research - 2022 -
Large organellar changes occur during mild heat shock in
yeast
Katharina Keuenhof, Lisa Larsson Berglund, Sandra Malmgren Hill, Kara Schneider, Per O Widlund, Thomas Nyström, Johanna L Höög
Journal of cell science - 2021 -
An Hsp90 co-chaperone links protein folding and degradation and is part of a conserved protein quality
control
Frederik Eisele, Anna Maria Eisele-Bürger, Xinxin Hao, Lisa Larsson Berglund, Johanna L Höög, Beidong Liu, Thomas Nyström
Cell Reports - 2021 -
Nuclear envelope budding is a response to cellular
stress.
Dimitra Panagaki, Jacob Croft, Katharina Keuenhof, Lisa Larsson Berglund, Stefanie Andersson, Verena Kohler, Sabrina Büttner, Markus J. Tamás, Thomas Nyström, Richard Neutze, Johanna L Höög
Proceedings of the National Academy of Sciences of the United States of America - 2021 -
Snd3 controls nucleus-vacuole junctions in response to glucose
signaling
S. Tosal-Castano, C. Peselj, V. Kohler, L. Habernig, Lisa Larsson Berglund, M. Ebrahimi, F. N. Vogtle, Johanna L Höög, C. Andreasson, S. Buttner
Cell Reports - 2021 -
Subpopulations of extracellular vesicles from human metastatic melanoma tissue identified by quantitative proteomics after optimized
isolation
Rossella Crescitelli, Cecilia Lässer, Su Chul Jang, Aleksander Cvjetkovic, Carina Malmhäll, Nasibeh Karimi, Johanna L Höög, Iva Johansson, Johannes Fuchs, Annika Thorsell, Y. S. Gho, Roger Olofsson Bagge, Jan Lötvall
Journal of Extracellular Vesicles - 2020 -
Axonemal doublet microtubules can split into two complete singlets in human sperm flagellum
tips.
Davide Zabeo, Jacob Croft, Johanna L Höög
FEBS letters - 2019 -
Composition, structure and function of the eukaryotic flagellum distal
tip
Jacob Croft, Davide Zabeo, Radhika Subramanian, Johanna L Höög
Essays in biochemistry - 2018 -
A lumenal interrupted helix in human sperm tail
microtubules
Davide Zabeo, J. M. Heumann, C. L. Schwartz, Azusa Suzuki-Shinjo, G. Morgan, Per O Widlund, Johanna L Höög
Scientific Reports - 2018 -
Extracellular vesicles in
motion
Aleksander Cvjetkovic, Rossella Crescitelli, Cecilia Lässer, Davide Zabeo, Per O Widlund, Thomas Nyström, Johanna L Höög, Jan Lötvall
Science Matters - 2017 -
3D ultrastructure of multi-vesicular bodies in fission
yeast
Davide Zabeo, Rossella Crescitelli, Eileen O'Toole, Helio Roque, Johanna L Höög
Science Matters - 2017 -
Exosomes purified from a single cell type have diverse
morphology
Davide Zabeo, Aleksander Cvjetkovic, Cecilia Lässer, Martin Schorb, Jan Lötvall, Johanna L Höög
Journal of extracellular vesicles - 2017 -
Detailed Analysis of Protein Topology of Extracellular Vesicles–Evidence of Unconventional Membrane Protein
Orientation
Aleksander Cvjetkovic, Su Chul Jang, Barbora Konečná, Johanna L Höög, Carina Sihlbom, Cecilia Lässer, Jan Lötvall
Scientific Reports - 2016 -
3D Architecture of the Trypanosoma brucei Flagella Connector, a Mobile Transmembrane
Junction
Johanna L Höög, Sylvain Lacomble, Cedric Bouchet-Marquis, Laura Briggs, Kristin Park, Andreas Hoenger, Keith Gull
PLoS Neglected Tropical Diseases - 2016 -
Diversity of extracellular vesicles in human ejaculates revealed by cryo-electron
microscopy
Johanna L Höög, Jan Lötvall
Journal of Extracellular Vesicles - 2015 -
Automated stitching of microtubule centerlines across serial electron
tomograms.
Britta Weber, Erin M Tranfield, Johanna L Höög, Daniel Baum, Claude Antony, Tony Hyman, Jean-Marc Verbavatz, Steffen Prohaska
PloS one - 2014 -
A simple Fourier filter for suppression of the missing wedge ray artefacts in single-axis electron tomographic
reconstructions.
Lubomír Kováčik, Sami Kereïche, Sami Kerïeche, Johanna L Höög, Pavel Jůda, Pavel Matula, Ivan Raška
Journal of structural biology - 2014 -
Modes of flagellar assembly in Chlamydomonas reinhardtii and Trypanosoma
brucei
Johanna L Höög, Sylvain Lacomble, Eileen O'Toole, Andreas Hoenger, Richard McIntosh, Keith Gull
eLife - 2014 -
Electron tomography reveals novel microtubule lattice and microtubule organizing centre defects in +TIP
mutants.
Johanna L Höög, Stephen M Huisman, Damian Brunner, Claude Antony
PloS one - 2013 -
Cryo-electron tomography and 3-D analysis of the intact flagellum in Trypanosoma
brucei.
Johanna L Höög, Cédric Bouchet-Marquis, J Richard McIntosh, Andreas Hoenger, Keith Gull
Journal of structural biology - 2012 -
Electron tomography reveals a flared morphology on growing microtubule
ends.
Johanna L Höög, Stephen M Huisman, Zsofia Sebö-Lemke, Linda Sandblad, J Richard McIntosh, Claude Antony, Damian Brunner
Journal of cell science - 2011 -
Beyond 9+0: noncanonical axoneme structures characterize sensory cilia from protists to
humans.
Eva Gluenz, Johanna L Höög, Amy E Smith, Helen R Dawe, Michael K Shaw, Keith Gull
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 2010 -
Ultrastructural investigation methods for Trypanosoma
brucei.
Johanna L Höög, Eva Gluenz, Sue Vaughan, Keith Gull
Methods in cell biology - 2010 -
Whole-cell investigation of microtubule cytoskeleton architecture by electron
tomography.
Johanna L Höög, C Antony
Methods in cell biology - 2007 -
Organization of interphase microtubules in fission yeast analyzed by electron
tomography.
Johanna L Höög, Cindi Schwartz, Angela T Noon, Eileen T O'Toole, David N Mastronarde, J Richard McIntosh, Claude Antony
Developmental cell - 2007