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Karolina Larsson
Affiliated to Research
Department of OncologyAbout Karolina Larsson
About Karolina Larsson
Medical Degree: 2007
Specialist in Clinical Oncology: 2018
Director of the Breast Center, Sahlgrenska University Hospital: 2022–2025
PhD: 2026
Karolina Larsson’s doctoral thesis focuses on metronomic chemotherapy and on the decision‑making processes involved when choosing between treatment options in later lines of therapy for metastatic breast cancer—an area where clear guidelines and strong evidence are often lacking. Her research demonstrates that metronomic chemotherapy is an effective treatment option for selected patients with metastatic breast cancer. The findings also highlight that patient autonomy is strengthened when oncologists make their own values and considerations explicit in the treatment recommendations they provide.
Read more about the research in her thesis: Metronomic chemotherapy – one of several treatment options for metastatic breast cancer
Karolina works as a Clinical Oncologist with breast cancer at Sahlgrenska University Hospital and continues to conduct research in the field of breast cancer.
Ongoing Research Projects
Time to Meet: Communication in Cancer Care
This qualitative research project investigates how patients and healthcare professionals communicate about incurable cancer. Both healthcare staff and patients are interviewed as part of the study. Data collection is currently underway.Participants: Matilda Liljedahl, Karolina Larsson, patient representative, among others.
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Prognostic performance of thymidine kinase 1 activity in patients with hormone receptor-positive and HER2-negative metastatic breast cancer treated with CDK4/6 and aromatase
inhibitors
Nicole L. Brown, Sacha J. Howell, Dimitrios Papantoniou, Olle Eriksson, Mattias Bergqvist, Amy Williams, Amy Kavanagh, Alexandra Backlund, Ahmed Albu-Kareem, Ellinor Elinder, Karolina Larsson, Monika Uminska, Maria Ekholm
Breast Cancer Research and Treatment - 2026 -
Plasma extracellular vesicles reflect response and prognosis in patients with breast cancer undergoing neoadjuvant
treatment
Karin Ekström, Nazia Riaz, Karolina Larsson, Antal Nemeth, Rossella Crescitelli, Barbro Linderholm, Roger Olofsson Bagge
Breast Cancer Research - 2026 -
Convenient but concerning: patients’ experiences of metronomic chemotherapy in metastatic breast
cancer
Karolina Larsson, Barbro Linderholm, Fredrik Wärnberg, Nataliya Berbyuk Lindström, Maria Ekholm, Matilda Liljedahl
J of Psychosocial Oncology Research and Practice - 2025 -
Changing Practices in Axillary Surgery After Neoadjuvant Breast Cancer Therapy: Insights From the EUSOMA European
Database
Antonio J. Esgueva, Mariano Tomatis, Antonio Ponti, Lorenza Marotti, Maria Joao Cardoso, Kwok Leung Cheung, Jakob De Vries, Peter van Dam, Isabel T. Rubio, Chiara Annunziata Pasqualina Anghelone, Antonella Baldissera, Elisabetta Benozzi, Martine Berlière, Marina Bortul, Barbara Bussels, Francesco Caruso, Carla Cedolini, Fabio Corsi, Evelyn Despierre, Boudewijn Dullens, Gianluca Fogazzi, Lucio Fortunato, José Luis Fougo, Gianluca Frisoni, Daniele Generali, Alessandra Gennari, Matteo Ghilli, Marco Golinelli, Pedro Gouveia, Simona Grossi, Ruth Helfgott, Alessandra Huscher, Karolina Larsson, Sophie Marquette, Carmela Mocerino, Ida Negreiros, Francesca Pellini, Federico Piacentini, Romano Polato, Annemie Prové, Karol Rogowski, Giovanna Romanucci, Lorenzo Rossi, Claudia Francesca Rossi, Margherita Serra, Gracienne Staelens, Maud Vassilieff, Paolo Veronesi, Daniele Zanoni
Journal of Surgical Oncology - 2025 -
The outcome of selective delayed sentinel lymph node biopsy following upfront omission of axillary staging in low-risk invasive breast cancers: a retrospective hypothetical simulated
analysis
Albin Bengtsson, Karolina Larsson, Kian Chin
Discover Oncology - 2025 -
Integration of personalised ultrasensitive ctDNA monitoring of patients with metastatic breast cancer to reduce imaging
requirements
Pia Mouhanna, Anders Ståhlberg, Daniel Andersson, Ahmed Albu-Kareem, Ellinor Elinder, Olle Eriksson, Amy Kavanagh, Anikó Kovács, Karolina Larsson, Barbro Linderholm, Monika Uminska, Tobias Österlund, Sacha J Howell, Maria Ekholm
International Journal of Cancer - 2025 -
Clinico-pathological features predicting indication to mastectomy in breast cancer patients achieving complete response after neoadjuvant therapy: A retrospective analysis of the EUSOMA
database
Giuseppe Catanuto, Damiano Gentile, Federica Martorana, Mariano Tomatis, Antonio Ponti, Lorenza Marotti, Cynthia Aristei, Maria Joao Cardoso, Kwok Leung Cheung, Giuseppe Curigliano, Jakob De Vries, Andreas Karakatsanis, Donatella Santini, Francesco Sardanelli, Peter Van Dam, Isabel T. Rubio, Chiara Annunziata Pasqualina Anghelone, Antonella Baldissera, Elisabetta Benozzi, Marina Bortul, Barbara Bussels, Katia Cagossi, Francesco Caruso, Fabio Corsi, Bogumila Czartoryska-Arlukowicz, Evelyn Despierre, Luca Despini, Boudewijn Dullens, Antonio Esgueva, Gianluca Fogazzi, Lucio Fortunato, José Luis Fougo, Gianluca Frisoni, Daniele Generali, Alessandra Gennari, Matteo Ghilli, Pedro Gouveia, Simona Grossi, Alessandra Huscher, Karolina Larsson, Henk Loobuyck, Monika Luethy, Sophie Marquette, Sigrid Metz-Gercek, Stefania Montemezzi, Ida Negreiros, Federico Piacentini, Annemie Prové, Ferdinando Riccardi, Giovanna Romanucci, Lorenzo Rossi, Margherita Serra, Gracienne Staelens, Aline van Maanen, Maud Vassilieff, Vasileios Venizelos, Paolo Veronesi, Daniele Zanoni
European Journal of Surgical Oncology - 2025 -
The impact of high exposure to perfluoroalkyl substances and risk for hormone receptor-positive breast cancer - A Swedish cohort
study.
Sofia Hammarstrand, Eva M. Andersson, Eva Andersson, Karolina Larsson, Yiyi Xu, Ying Li, Kristina Jakobsson
Environment international - 2024 -
Treatment and outcomes in breast cancer patients: A cross section study from the EUSOMA breast centre
network.
Cynthia Aristei, Mariano Tomatis, Antonio Ponti, Lorenza Marotti, Maria Joao Cardoso, Kwok Leung Cheung, Giuseppe Curigliano, Jakob De Vries, Donatella Santini, Francesco Sardanelli, Peter Van Dam, Isabel Teresa Rubio, Karolina Larsson
European Journal of Cancer - 2024 -
Metronomic chemotherapy using capecitabine and cyclophosphamide in metastatic breast cancer - efficacy, tolerability and quality of life results from the phase II METRO
trial
Karolina Larsson, Jamila Adra, Leif Klint, Barbro Linderholm
Breast - 2024 -
Comparison of breast cancer surrogate subtyping using a closed-system RT-qPCR breast cancer assay and immunohistochemistry on 100 core needle biopsies with matching surgical
specimens.
Slavica Janeva, Toshima Z Parris, Salmir Nasic, Shahin De Lara, Karolina Larsson, Riccardo A Audisio, Roger Olofsson, Anikó Kovács
BMC Cancer - 2021 -
Genomic and Transcriptomic Analyses of Breast Cancer Primaries and Matched Metastases in AURORA, the Breast International Group (BIG) Molecular Screening
Initiative.
Eva M Ciruelos, Philippe Aftimos, Mafalda Oliveira, Alexandre Irrthum, Debora Fumagalli, Christos Sotiriou, Einav Nili Gal-Yam, Mark E Robson, Justin Ndozeng, Angelo Di Leo, Evandro de Azambuja, Giuseppe Viale, Elsemieke D Scheepers, Giuseppe Curigliano, Judith M Bliss, Jorge S Reis-Filho, Marco Colleoni, Marija Balic, Fatima Cardoso, Joan Albanell, Caroline Duhem, Sandrine Marreaud, Dario Romagnoli, Beatriz Rojas, Andrea Gombos, Hans Wildiers, Angel Guerrero-Zotano, Peter Hall, Andrea Bonetti, Karolina Larsson, Martina Degiorgis, Silvia Khodaverdi, Richard Greil, Ásgerdur Sverrisdóttir, Marta Paoli, Ethel Seyll, Sibylle Loibl, Barbro Linderholm, Gabriele Zoppoli, Nancy E Davidson, Oskar Th Johannsson, Philippe L Bedard, Sherene Loi, Susan Knox, David A Cameron, Nadia Harbeck, Maite Lasa Montoya, Mariana Brandão, Andrea Vingiani, Carmela Caballero, Florentine S Hilbers, Lucy R Yates, Matteo Benelli, David Venet, Martine J Piccart
Cancer Discovery - 2021 -
Efficacy and tolerability of metronomic chemotherapy in patients with metastatic breast cancer - an international experience in West Sweden and in the South of
Ireland.
Catherine Weadick, Karolina Larsson, Seamus O'Reilly, Eileen McMahon, Deirdre O'Mahony, Barbro Linderholm
Cancer Treatment and Research Communications - 2020