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Annika Wahlström
Forskningsrådgivare
Forsknings- och innovationskontoret-
From human to superhuman: the impact of the microbiome on
physiology
Stephen J. Keely, Paul D. Cotter, Annika Wahlström, Harriet Schellekens, David Weinkove, Kim E. Barrett
JOURNAL OF PHYSIOLOGY-LONDON - 2025 -
An integrated analysis of bile acid metabolism in humans with severe
obesity
Ömrüm Aydin, Annika Wahlström, Patrick A. De Jonge, Abraham S. Meijnikman, Wilhelm Sjöland, Lisa M. Olsson, Marcus Henricsson, Marcus C. De Goffau, Stijn Oonk, Sjoerd C. Bruin, Yair I.Z. Acherman, Hanns-Ulrich Marschall, Victor E.A. Gerdes, Max Nieuwdorp, Fredrik Bäckhed, Albert K. Groen
Hepatology - 2025 -
Alterations in bile acid kinetics after bariatric surgery in patients with obesity with or without type 2
diabetes
Annika Wahlström, Omrum Aydin, Lisa M. Olsson, Wilhelm Sjöland, Marcus Henricsson, Annika Lundqvist, Hanns-Ulrich Marschall, Rutger Franken, Arnold van de Laar, Victor Gerdes, Abraham S. Meijnikman, Dag Hofso, Albert K. Groen, Joran Hjelmesaeth, Max Nieuwdorp, Fredrik Bäckhed
EBioMedicine - 2024 -
Production of deoxycholic acid by low-abundant microbial species is associated with impaired glucose
metabolism
Annika Wahlström, Ariel Brumbaugh, Wilhelm Sjöland, Lisa M. Olsson, Hao Wu, Marcus Henricsson, Annika Lundqvist, Kassem Makki, Stanley L. Hazen, Göran Bergström, Hanns-Ulrich Marschall, Michael A. Fischbach, Fredrik Bäckhed
NATURE COMMUNICATIONS - 2024 -
6 alpha-hydroxylated bile acids mediate TGR5 signalling to improve glucose metabolism upon dietary fiber supplementation in
mice
Kassem Makki, Harald Brolin, N. Petersen, Marcus Henricsson, D. P. Christensen, Muhammad Tanweer Khan, Annika Wahlström, Per-Olof Bergh, Valentina Tremaroli, K. Schoonjans, Hanns-Ulrich Marschall, Fredrik Bäckhed
Gut - 2023 -
Absence of gut microbiota reduces neonatal survival and exacerbates liver disease in Cyp2c70-deficient mice with a human-like bile acid
composition
Wilhelm Sjöland, Annika Wahlström, Kassem Makki, Marc Schöler, Antonio Molinaro, Lisa M. Olsson, Thomas U. Greiner, Robert Caesar, J. F. de Boer, F. Kuipers, Fredrik Bäckhed, Hanns-Ulrich Marschall
Clinical Science - 2023 -
Tetrahydroxylated bile acids improve cholestatic liver and bile duct injury in the Mdr2(-/-) mouse model of sclerosing cholangitis via immunomodulatory
effects
C. D. Fuchs, E. D. Dixon, T. Hendrikx, V. Mlitz, Annika Wahlström, Marcus Ståhlman, H. Scharnagl, T. Stojakovic, C. J. Binder, Hanns-Ulrich Marschall, M. Trauner
Hepatology communications. - 2022 -
Gut microbiota depletion exacerbates cholestatic liver injury via loss of FXR
signalling
K. M. Schneider, L. S. Candels, J. R. Hov, M. Myllys, R. Hassan, C. V. Schneider, Annika Wahlström, A. Mohs, S. Zuhlke, L. J. Liao, C. Elfers, K. Kilic, Marcus Henricsson, Antonio Molinaro, M. Hatting, A. Zaza, D. Drasdo, M. Frissen, A. S. Devlin, E. J. C. Galvez, T. Strowig, T. H. Karlsen, J. G. Hengstler, Hanns-Ulrich Marschall, A. Ghallab, C. Trautwein
Nature Metabolism - 2021 -
FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid
absorption
B. L. Clifford, L. R. Sedgeman, K. J. Williams, P. Morand, A. Cheng, K. E. Jarrett, A. P. Chan, M. C. Brearley-Sholto, Annika Wahlström, J. W. Ashby, W. Barshop, J. Wohlschlegel, A. C. Calkin, Y. Y. Liu, A. Thorell, P. J. Meikle, B. G. Drew, J. J. Mack, Hanns-Ulrich Marschall, E. J. Tarling, P. A. Edwards, T. Q. D. Vallim
Cell Metabolism - 2021 -
Absence of Bsep/Abcb11 attenuates MCD diet-induced hepatic steatosis but aggravates inflammation in
mice
C. D. Fuchs, S. Krivanec, D. Steinacher, V. Mlitz, Annika Wahlström, Marcus Ståhlman, T. Claudel, H. Scharnagl, T. Stojakovic, Hanns-Ulrich Marschall, M. Trauner
Liver International - 2020 -
Obeticholic acid improves fetal bile acid profile in a mouse model of gestational
hypercholanemia.
Vanessa Pataia, Saraid McIlvride, Georgia Papacleovoulou, Caroline Ovadia, Julie A K McDonald, Annika Wahlström, Eugene Jansen, Luciano Adorini, David Shapiro, Julian R Marchesi, Hanns-Ulrich Marschall, Catherine Williamson
American journal of physiology. Gastrointestinal and liver physiology - 2020 -
Ursodeoxycholic acid enriches intestinal bile salt hydrolase-expressing Bacteroidetes in cholestatic
pregnancy
C. Ovadia, A. Perdones-Montero, H. M. Fan, B. H. Mullish, J. A. K. McDonald, G. Papacleovoulou, Annika Wahlström, Marcus Ståhlman, A. Tsakmaki, L. C. D. Clarke, A. Sklavounos, P. H. Dixon, G. A. Bewick, J. R. F. Walters, Hanns-Ulrich Marschall, J. R. Marchesi, C. Williamson
Scientific Reports - 2020 -
Obeticholic acid may increase the risk of gallstone formation in susceptible
patients.
Samer Al-Dury, Annika Wahlström, Katrin Panzitt, Anders Thorell, Marcus Ståhlman, Michael Trauner, Peter Fickert, Fredrik Bäckhed, Lars Fändriks, Martin Wagner, Hanns-Ulrich Marschall
Journal of hepatology - 2019 -
Intestinal dysbiosis augments liver disease progression via NLRP3 in a murine model of primary sclerosing
cholangitis.
Lijun Liao, Kai Markus Schneider, Eric J C Galvez, Mick Frissen, Hanns-Ulrich Marschall, Huan Su, Maximilian Hatting, Annika Wahlström, Johannes Haybaeck, Philip Puchas, Antje Mohs, Jin Peng, Ina Bergheim, Anika Nier, Julia Hennings, Johanna Reißing, Henning W Zimmermann, Thomas Longerich, Till Strowig, Christian Liedtke, Francisco J Cubero, Christian Trautwein
Gut - 2019 -
Obeticholic acid ameliorates dyslipidemia but not glucose tolerance in mouse model of gestational
diabetes.
Saraid McIlvride, Vanya Nikolova, Hei Man Fan, Julie A K McDonald, Annika Wahlström, Elena Bellafante, Eugene Jansen, Luciano Adorini, David Shapiro, Peter Jones, Julian R Marchesi, Hanns-Ulrich Marschall, Catherine Williamson
American journal of physiology. Endocrinology and metabolism - 2019 -
Simplified Intestinal Microbiota to Study Microbe-Diet-Host Interactions in a Mouse
Model
Petia Kovatcheva-Datchary, S. Shoaie, S. Lee, Annika Wahlström, I. Nookaew, Anna Hallén, Rosie Perkins, J. Nielsen, Fredrik Bäckhed
Cell Reports - 2019 -
Outside the liver box: The gut microbiota as pivotal modulator of liver
diseases
Annika Wahlström
Biochimica Et Biophysica Acta-Molecular Basis of Disease - 2019 -
Colesevelam attenuates cholestatic liver and bile duct injury in Mdr2-/- mice by modulating composition, signalling and excretion of faecal bile
acids.
Claudia Daniela Fuchs, Gustav Paumgartner, Veronika Mlitz, Victoria Kunczer, Emina Halilbasic, Nadja Leditznig, Annika Wahlström, Marcus Ståhlman, Andrea Thüringer, Karl Kashofer, Tatjana Stojakovic, Hanns-Ulrich Marschall, Michael Trauner
Gut - 2018 -
Pilot study with IBAT inhibitor A4250 for the treatment of cholestatic pruritus in primary biliary
cholangitis
Samer Al-Dury, Annika Wahlström, S. Wahlin, J. Langedijk, R. O. Elferink, Marcus Ståhlman, Hanns-Ulrich Marschall
Scientific Reports - 2018 -
Role of Bile Acids in Metabolic
Control.
Antonio Molinaro, Annika Wahlström, Hanns-Ulrich Marschall
Trends in endocrinology and metabolism: TEM - 2018 -
Crosstalk between Bile Acids and Gut Microbiota and Its Impact on Farnesoid X Receptor
Signalling
Annika Wahlström, Petia Kovatcheva-Datchary, Marcus Ståhlman, Fredrik Bäckhed, Hanns-Ulrich Marschall
Digestive Diseases - 2017 -
NorUrsodeoxycholic acid ameliorates cholemic nephropathy in bile duct ligated
mice
E. Krones, K. Eller, M. J. Pollheimer, S. Racedo, A. H. Kirsch, B. Frauscher, Annika Wahlström, Marcus Ståhlman, M. Trauner, F. Grahammer, T. B. Huber, K. Wagner, A. R. Rosenkranz, Hanns-Ulrich Marschall, P. Fickert
Journal of Hepatology - 2017 -
Induction of FXR signaling in germ-free mice colonized with a human
microbiota.
Annika Wahlström, Petia Kovatcheva-Datchary, Marcus Ståhlman, Muhammad Tanweer Khan, Fredrik Bäckhed, Hanns-Ulrich Marschall
Journal of lipid research - 2017 -
Metabolic preconditioning protects BSEP/ABCB11(-/-) mice against cholestatic liver
injury.
Claudia D Fuchs, Gustav Paumgartner, Annika Wahlström, Philipp Schwabl, Thomas Reiberger, Nadja Leditznig, Tatjana Stojakovic, Nataliya Rohr-Udilova, Peter Chiba, Hanns-Ulrich Marschall, Michael Trauner
Journal of hepatology - 2017 -
Cyp3a11 is not essential for the formation of murine bile
acids
Annika Wahlström, Samer Al-Dury, Marcus Ståhlman, Fredrik Bäckhed, Hanns-Ulrich Marschall
Biochemistry and Biophysics Reports - 2017 -
Inhibition of intestinal bile acid absorption improves cholestatic liver and bile duct injury in a mouse model of sclerosing
cholangitis
A. Baghdasaryan, C. D. Fuchs, C. H. Osterreicher, U. J. Lemberger, E. Halilbasic, I. Pahlman, H. Graffner, E. Krones, P. Fickert, Annika Wahlström, Marcus Ståhlman, G. Paumgartner, Hanns-Ulrich Marschall, M. Trauner
Journal of Hepatology - 2016 -
Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host
Metabolism.
Annika Wahlström, Sama I. Sayin, Hanns-Ulrich Marschall, Fredrik Bäckhed
Cell metabolism - 2016 -
Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR
antagonist.
Sama I. Sayin, Annika Wahlström, Jenny Felin, Sirkku Jäntti, Hanns-Ulrich Marschall, Krister Bamberg, Bo Angelin, Tuulia Hyötyläinen, Matej Orešič, Fredrik Bäckhed
Cell metabolism - 2013 -
Targeting the protein prenyltransferases efficiently reduces tumor development in mice with K-RAS-induced lung
cancer
Meng Liu, Anna-Karin Sjögren, Christin Karlsson, Mohamed X Ibrahim, Karin Andersson, Frida J Olofsson, Annika Wahlström, Martin Dalin, Huiming Yu, Zhenggang Chen, Shao H. Yang, Stephen G. Young, Martin Bergö
Proceedings of the National Academy of Sciences of the United States of America - 2010 -
Nf1 deficiency cooperates with oncogenic K-RAS to induce acute myeloid leukemia in
mice.
Briony Cutts, Anna-Karin Sjögren, Karin Andersson, Annika Wahlström, Christin Karlsson, Birgitta Swolin, Martin Bergö
Blood - 2009 -
Defining RCE1 and ICMT as Therapeutic Targets in K-RAS-induced
Cancer
Annika Wahlström
2009 -
Genetic analyses of the role of RCE1 in RAS membrane association and
transformation.
Martin Bergö, Annika Wahlström, Loren G. Fong, Stephen G Young
Methods in enzymology - 2008 -
Inactivating Icmt ameliorates K-RAS-induced myeloproliferative
disease.
Annika Wahlström, Briony Cutts, Meng Liu, Annika Lindskog, Christin Karlsson, Anna-Karin Sjögren, Karin Andersson, Stephen G Young, Martin Bergö
Blood - 2008 -
GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS-induced lung
cancer
Anna-Karin Sjögren, Karin Andersson, Meng Liu, Briony Cutts, Christina Karlsson, Annika Wahlström, Martin Dalin, C. Weinbaum, P. J. Casey, Andrej Tarkowski, Birgitta Swolin, S. G. Young, Martin Bergö
J Clin Invest - 2007 -
Rce1 deficiency accelerates the development of K-RAS-induced myeloproliferative
disease
Annika Wahlström, Briony Cutts, Christin Karlsson, Karin Andersson, Meng Liu, Anna-Karin Sjögren, Birgitta Swolin, S. G. Young, Martin Bergö
Blood - 2007