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Virulence inhibitors for the treatment of soft tissue infections

Research project
Active research
Project size
2,5 MSEK
Project period
2017 - 2020
Project owner
Margarita Trobos and Maria Werthén, CARe, University of Gothenburg, Sweden and Sofia Almqvist and Erik Gerner, Mölnlycke Health Care, Sweden

Stiftelsen för Strategisk Forskning, Mölnlycke Health Care

Short description

The overall objective is to present an alternative treatment to antibiotics for wound management. This novel strategy is based on the inhibition of bacterial signalling (quorum sensing, QS), which controls bacterial virulence (toxicity) and resistance to immune cells. This approach would render bacteria incapable of establishing infection or disarm an established biofilm with low risk for resistance.