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NoCURE: Novel Carbapenemases - UnRaveling the Enviromental reservoir

Research project
Inactive research
Project size
11,4 MSEK
Project period
2014 - 2017
Project owner
Joakim Larsson and Erik Kristiansson

Short description

In this project, we will identify novel carbapenemase candidates using e.g. computational predictions of fragmented metagenomic DNA, functional metagenomics, and plasmid capture experiments. We will then characterize their structure, resistance and mobility potential. The research aims to increase our basic understanding of carbapenemases, including their abundance, diversity and transfer mechanisms.