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- Lenka Nováková Nyrén
Lenka Nováková Nyrén
Affiliated to Research
Department of Clinical-
Serum neurofilament light for detecting disease activity in individual patients in multiple sclerosis: A 48-week prospective single-center
study
Magnus Johnsson, Y. T. Stenberg, H. H. Farman, Kaj Blennow, Henrik Zetterberg, Clas Malmeström, Sofia Sandgren, Igal Rosenstein, Jan Lycke, Markus Axelsson, Lenka Novakova
MULTIPLE SCLEROSIS JOURNAL - 2024 -
Medically unexplained symptoms are common in women in tertiary neurological healthcare center: A survey cohort study of persons investigated for suspected multiple
sclerosis
Lenka Novakova, Anna Karin Hedstrom, Markus Axelsson, Anne Brandt, Lars Alfredsson, Tomas Olsson, Jan Lycke
BRAIN AND BEHAVIOR - 2024 -
High temperature requirement A1 and macrophage migration inhibitory factor in the cerebrospinal fluid; a potential marker of conversion from relapsing-remitting to secondary progressive multiple
sclerosis
Simone Hjæresen, Eirikur Benedikz, Tobias Sejbaek, Markus Axelsson, Lenka Novakova, Mengliang Zhang, Jan Lycke, Zsolt Illes, Åsa Fex-Svenningsen
Journal of the Neurological Sciences - 2024 -
Intrathecal kappa free light chain synthesis is associated with worse prognosis in relapsing-remitting multiple
sclerosis
Igal Rosenstein, Markus Axelsson, Lenka Novakova, Clas Malmeström, Kaj Blennow, Henrik Zetterberg, Jan Lycke
Journal of Neurology - 2023 -
A five-year observational prospective mono-center study of the efficacy of alemtuzumab in a real-world cohort of patients with multiple
sclerosis.
Sofia Sandgren, Lenka Nováková Nyrén, Anna Nordin, Markus Axelsson, Clas Malmeström, Henrik Zetterberg, Jan Lycke
Frontiers in neurology - 2023 -
Cerebrospinal fluid sulfatide isoforms lack diagnostic utility in separating progressive from relapsing-remitting multiple
sclerosis.
Lenka Novakova, Marcus Henricsson, Elias Björnson, Markus Axelsson, Jan Borén, Igal Rosenstein, Jan Lycke, Susanna Cardell, Maria K. Blomqvist
Multiple sclerosis and related disorders - 2023 -
The role of autoimmune antibodies to predict secondary autoimmunity in patients with relapsing-remitting multiple sclerosis treated with alemtuzumab: A nationwide prospective
survey
Sofia Sandgren, Lenka Novakova, Markus Axelsson, Firoozeh Amirbeagi, I. Kockum, T. Olsson, Clas Malmeström, Jan Lycke
Frontiers in Neurology - 2023 -
High levels of kappa free light chain synthesis predict cognitive decline in relapsing-remitting multiple
sclerosis
Igal Rosenstein, Markus Axelsson, Lenka Novakova, S. Rasch, Kaj Blennow, Henrik Zetterberg, Jan Lycke
FRONTIERS IN IMMUNOLOGY - 2023 -
MIF in the cerebrospinal fluid is decreased during relapsing-remitting while increased in secondary progressive multiple
sclerosis
S. Hjaeresen, T. Sejbaek, Markus Axelsson, S. K. Mortensen, H. Vinslov-Jensen, G. Pihl-Jensen, Lenka Novakova, C. B. Pedersen, B. Halle, F. R. Poulsen, M. L. Zhang, E. Benedikz, J. L. Frederiksen, Jan Lycke, Z. Illes, A. Fex-Svenningsen
Journal of the Neurological Sciences - 2022 -
Increased intrathecal neurofilament light and immunoglobulin M predict severe disability in relapsing-remitting multiple
sclerosis
Igal Rosenstein, S. Rasch, Markus Axelsson, Lenka Novakova, Kaj Blennow, Henrik Zetterberg, Jan Lycke
Frontiers in Immunology - 2022 -
Cerebrospinal fluid amyloid precursor protein as a potential biomarker of fatigue in multiple sclerosis: A pilot
study
Kalle Johansson, Pontus Wasling, Lenka Novakova, S. Sjodin, Ann Brinkmalm, Gunnar Brinkmalm, Kaj Blennow, Henrik Zetterberg, Markus Axelsson
Multiple Sclerosis and Related Disorders - 2022 -
Exploring CSF neurofilament light as a biomarker for MS in clinical practice; a retrospective registry-based
study
Igal Rosenstein, Markus Axelsson, Lenka Novakova, Kaj Blennow, Henrik Zetterberg, Jan Lycke
Multiple Sclerosis Journal - 2022 -
Kappa free light chain index as a diagnostic biomarker in multiple sclerosis: A real-world
investigation
Igal Rosenstein, S. Rasch, Markus Axelsson, Lenka Novakova, Kaj Blennow, Henrik Zetterberg, Jan Lycke
Journal of Neurochemistry - 2021 -
A multicentre validation study of the diagnostic value of plasma neurofilament
light.
Nicholas J. Ashton, Shorena Janelidze, Ahmad Al Khleifat, Antoine Leuzy, Emma L van der Ende, Thomas Karikari, Andrea L Benedet, Tharick A Pascoal, Alberto Lleó, Lucilla Parnetti, Daniela Galimberti, Laura Bonanni, Andrea Pilotto, Alessandro Padovani, Jan Lycke, Lenka Novakova, Markus Axelsson, Latha Velayudhan, Gil D Rabinovici, Bruce Miller, Carmine Pariante, Naghmeh Nikkheslat, Susan M Resnick, Madhav Thambisetty, Michael Schöll, Gorka Fernández-Eulate, Francisco J Gil-Bea, Adolfo López de Munain, Ammar Al-Chalabi, Pedro Rosa-Neto, Andre Strydom, Per Svenningsson, Erik Stomrud, Alexander Santillo, Dag Aarsland, John C van Swieten, Sebastian Palmqvist, Henrik Zetterberg, Kaj Blennow, Abdul Hye, Oskar Hansson
Nature communications - 2021 -
Persons with suspicious onset of multiple sclerosis but with undetermined diagnosis had persistent lower cognition and reduced quality of
life
Clara Constantinescu, Lenka Novakova, Clas Malmeström, Radu Constantinescu, Markus Axelsson, Jan Lycke
Multiple Sclerosis and Related Disorders - 2021 -
The levels of the serine protease HTRA1 in cerebrospinal fluid correlate with progression and disability in multiple
sclerosis
S. Hjaeresen, T. Sejbaek, Markus Axelsson, H. Vinslov-Jensen, S. K. Mortensen, G. Pihl-Jensen, Lenka Novakova, J. D. R. Christensen, C. B. Pedersen, B. Halle, F. R. Poulsen, J. L. Frederiksen, M. L. Zhang, E. Benedikz, Jan Lycke, Z. Illes, A. F. Svenningsen
Journal of Neurology - 2021 -
Autologous haematopoietic stem cell transplantation compared with alemtuzumab for relapsing-remitting multiple sclerosis: An observational
study
Christina Zhukovsky, Sofia Sandgren, Thomas Silfverberg, Sigrun Einarsdottir, Andreas Tolf, Anne Marie Landtblom, Lenka Novakova, Markus Axelsson, Clas Malmeström, Honar Cherif, Kristina Carlson, Jan Lycke, Joachim Burman
Journal of Neurology, Neurosurgery and Psychiatry - 2021 -
Inflammation-related plasma and CSF biomarkers for multiple
sclerosis
J. Huang, M. Khademi, L. Fugger, O. Lindhe, Lenka Novakova, Markus Axelsson, Clas Malmeström, Clara Constantinescu, Jan Lycke, F. Piehl, T. Olsson, I. Kockum
Proceedings of the National Academy of Sciences of the United States of America - 2020 -
NFL and CXCL13 may reveal disease activity in clinically and radiologically stable
MS
Lenka Novakova, M Axelsson, Clas Malmeström, Henrik Zetterberg, Kaj Blennow, A. Svenningsson, Jan Lycke
Multiple Sclerosis and Related Disorders - 2020 -
Neurofilament light for measuring the treatment efficacy in clinical practice: are we there
yet?
Lenka Novakova
Journal of neurology, neurosurgery, and psychiatry - 2019 -
Cerebrospinal fluid biomarkers in patients with neurological symptoms but without neurological
diseases
Radu Constantinescu, Ubah Mahamud, Clara Constantinescu, Barbro Eriksson, Lenka Novakova, Bob Olsson, Lars Rosengren, Kaj Blennow, Markus Axelsson
Acta Neurologica Scandinavica - 2019 -
Cerebrospinal fluid NCAM levels are modulated by disease-modifying
therapies
Markus Axelsson, N. Dubuisson, Lenka Novakova, Clas Malmeström, G. Giovannoni, Jan Lycke, S. Gnanapavan
Acta Neurologica Scandinavica - 2019 -
Natalizumab, rituximab and fingolimod as escalation therapy in multiple
sclerosis
M. Boremalm, A. Juto, Markus Axelsson, Lenka Novakova, T. Frisell, A. Svenningsson, Jan Lycke, F. Piehl, J. Selzer
European Journal of Neurology - 2019 -
Cerebrospinal fluid growth-associated protein 43 in multiple
sclerosis.
Åsa P Sandelius, Sofia Sandgren, Markus Axelsson, Clas Malmeström, Lenka Novakova, Vesna Kostanjevecki, Manu Vandijck, Kaj Blennow, Henrik Zetterberg, Jan Lycke
Scientific reports - 2019 -
Sulfatide isoform pattern in cerebrospinal fluid discriminates progressive MS from relapsing-remitting
MS
Lenka Novakova, Avadhesh Kumar Singh, Markus Axelsson, Marcus Ståhlman, Martin Adiels, Clas Malmeström, Henrik Zetterberg, Jan Borén, Jan Lycke, Susanna Cardell, Maria K. Blomqvist
Journal of Neurochemistry - 2018 -
Searching for neurodegeneration in multiple sclerosis at clinical onset: Diagnostic value of
biomarkers.
Lenka Novakova, Markus Axelsson, Clas Malmeström, Henrik Imberg, Henrik Zetterberg, Olle Nerman, Jan Lycke
PloS one - 2018 -
Diffusion tensor imaging in multiple sclerosis at different final
outcomes
Oluf Andersen, Anders Hildeman, Marco Longfils, Helen Tedeholm, Bengt Skoog, Wei Tian, Jianhui Zhong, Sven Ekholm, Lenka Novakova, Björn Runmarker, Olle Nerman, Stephan E Maier
Acta Neurologica Scandinavica - 2018 -
Biomarkers in Multiple Sclerosis - Monitoring disease activity and treatment
afficacy
Lenka Nováková Nyrén
2018 -
Cerebrospinal fluid biomarkers as a measure of disease activity and treatment efficacy in relapsing-remitting multiple
sclerosis.
Lenka Nováková Nyrén, Markus Axelsson, Mohsen Khademi, Henrik Zetterberg, Kaj Blennow, Clas Malmeström, Fredrik Piehl, Tomas Olsson, Jan Lycke
Journal of neurochemistry - 2017 -
Monitoring disease activity in multiple sclerosis using serum neurofilament light
protein.
Lenka Novakova, Henrik Zetterberg, Peter Sundström, Markus Axelsson, Martin Gunnarsson, Clas Malmeström, Fredrik Piehl, Kaj Blennow, Jan Lycke
Neurology - 2017 -
Cerebrospinal fluid biomarkers of inflammation and degeneration as measures of fingolimod efficacy in multiple
sclerosis.
Lenka Novakova, Markus Axelsson, Mohsen Khademi, Henrik Zetterberg, Kaj Blennow, Clas Malmeström, Fredrik Piehl, Thomas Olsson, Jan Lycke
Multiple sclerosis (Houndmills, Basingstoke, England) - 2017 -
High Interferon-γ Uniquely in Vδ1 T Cells Correlates with Markers of Inflammation and Axonal Damage in Early Multiple
Sclerosis.
Avadhesh Kumar Singh, Lenka Novakova, Markus Axelsson, Clas Malmeström, Henrik Zetterberg, Jan Lycke, Susanna Cardell
Frontiers in Immunology - 2017 -
Soluble TREM-2 in cerebrospinal fluid from patients with multiple sclerosis treated with natalizumab or
mitoxantrone.
Annika Öhrfelt, Markus Axelsson, Clas Malmeström, Lenka Novakova, Amanda Heslegrave, Kaj Blennow, Jan Lycke, Henrik Zetterberg
Multiple sclerosis (Houndmills, Basingstoke, England) - 2016 -
Rituximab versus Fingolimod after Natalizumab in Multiple Sclerosis
Patients
P. Alping, T. Frisell, Lenka Novakova, P. Islam-Jakobsson, J. Salzer, A. Bjorck, Markus Axelsson, Clas Malmeström, K. Fink, Jan Lycke, A. Svenningsson, F. Piehl
Annals of Neurology - 2016 -
Rituximab in multiple
sclerosis
J. Salzer, R. Svenningsson, P. Alping, Lenka Novakova, A. Björck, K. Fink, P. Islam-Jakobsson, Clas Malmeström, Markus Axelsson, M. Vågberg, P. Sundström, Jan Lycke, F. Piehl, A. Svenningsson
Neurology - 2016 -
Reduced cerebrospinal fluid concentrations of oxysterols in response to natalizumab treatment of relapsing remitting multiple
sclerosis.
Lenka Novakova, Markus Axelsson, Clas Malmeström, Henrik Zetterberg, Ingemar Björkhem, Virginija Danylaité Karrenbauer, Jan Lycke
Journal of the Neurological Sciences - 2015 -
Clinically isolated syndromes with no further disease activity suggestive of multiple sclerosis at the age of population life
expectancy
Lenka Novakova, Bengt Skoog, Björn Runmarker, Sven Ekholm, Stefan Winblad, Vera Lisovskaja, Oluf Andersen
Multiple sclerosis journal - 2014