Annika Nerstedt

The impact of cellular senescence in human adipose

Annika Nerstedt, Ulf Smith
Journal of Cell Communication and Signaling - 2023

Increased cell senescence in human metabolic

Rosa Spinelli, Ritesh Baboota, Silvia Gogg, F. Beguinot, M. Bluher, Annika Nerstedt, Ulf Smith
Journal of Clinical Investigation - 2023

ZMAT3 hypomethylation contributes to early senescence of preadipocytes from healthy first-degree relatives of type 2

diabetics

R. Spinelli, P. Florese, L. Parrillo, F. Zatterale, M. Longo, V. D'Esposito, A. Desiderio, Annika Nerstedt, Birgit Gustafson, P. Formisano, C. Miele, G. A. Raciti, R. Napoli, Ulf Smith, F. Beguinot
Aging Cell - 2022

Type 2 Diabetes, Independent of Obesity and Age, Is Characterized by Senescent and Dysfunctional Mature Human Adipose

Cells

Birgit Gustafson, Annika Nerstedt, R. Spinelli, F. Beguinot, Ulf Smith
Diabetes - 2022

Depletion of protein kinase STK25 ameliorates renal lipotoxicity and protects against diabetic kidney

disease.

Emmelie Cansby, Mara Caputo, Lei Gao, Nagaraj M. Kulkarni, Annika Nerstedt, Marcus Ståhlman, Jan Borén, Rando Porosk, Ursel Soomets, Matteo Pedrelli, Paolo Parini, Hanns-Ulrich Marschall, Jenny Nyström, Brian W Howell, Margit Mahlapuu
JCI insight - 2020

Lipid droplet-associated kinase STK25 regulates peroxisomal activity and metabolic stress response in steatotic

liver

Annika Nerstedt, Yeshwant Kurhe, Emmelie Cansby, Mara Caputo, Lei Gao, Egor Vorontsov, Marcus Ståhlman, Esther Nuñez Durán, Jan Borén, Hanns-Ulrich Marschall, Douglas G. Mashek, D. N. Saunders, Carina Sihlbom, A. J. Hoy, Margit Mahlapuu
Journal of Lipid Research - 2020

Protein kinase MST3 modulates lipid homeostasis in hepatocytes and correlates with nonalcoholic steatohepatitis in

humans.

Emmelie Cansby, Nagaraj M. Kulkarni, Elin Magnusson, Yeshwant Kurhe, Manoj Amrutkar, Annika Nerstedt, Marcus Ståhlman, Carina Sihlbom, Hanns-Ulrich Marschall, Jan Borén, Matthias Blüher, Margit Mahlapuu
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 2019

Human adipose tissue microvascular endothelial cells secrete PPARγ ligands and regulate adipose tissue lipid

uptake.

Silvia Gogg, Annika Nerstedt, Jan Borén, Ulf Smith
JCI insight - 2019

Reduced subcutaneous adipogenesis in human hypertrophic obesity is linked to senescent precursor

cells

Birgit Gustafson, Annika Nerstedt, Ulf Smith
Nature Communications - 2019

Impaired Adipogenesis and Dysfunctional Adipose Tissue in Human Hypertrophic

Obesity

Ann Hammarstedt, Silvia Gogg, Shahram Hedjazifar, Annika Nerstedt, Ulf Smith
Physiological Reviews - 2018

Elevated Plasma Levels of 3-Hydroxyisobutyric Acid Are Associated With Incident Type 2

Diabetes

A. Mardinoglu, Silvia Gogg, L. A. Lotta, A. Stancakova, Annika Nerstedt, Jan Borén, M. Bluher, E. Ferrannini, C. Langenberg, N. J. Wareham, M. Laakso, Ulf Smith
Ebiomedicine - 2018

Overexpressing the novel autocrine/endocrine adipokine WISP2 induces hyperplasia of the heart, white and brown adipose tissues and prevents insulin

resistance.

John Grünberg, Jenny M Hoffmann, Shahram Hedjazifar, Annika Nerstedt, Lachmi E Jenndahl, Johannes Elvin, John Castellot, Lan Wei, Sofia Movérare-Skrtic, Claes Ohlsson, Louise Mannerås Holm, Fredrik Bäckhed, Ismail Syed, Fatima Bosch, Alan Saghatelian, Barbara B Kahn, Ann Hammarstedt, Ulf Smith
Scientific reports - 2017

Partial hepatic resistance to IL-6-induced inflammation develops in type 2 diabetic mice, while the anti-inflammatory effect of AMPK is

maintained

Emmelie Cansby, Annika Nerstedt, Manoj Amrutkar, Esther Nuñez Durán, Ulf Smith, Margit Mahlapuu
Molecular and Cellular Endocrinology - 2014

Increased expression of STK25 leads to impaired glucose utilization and insulin sensitivity in mice challenged with a high-fat

diet.

Emmelie Cansby, Manoj Amrutkar, Louise Mannerås Holm, Annika Nerstedt, Azadeh Reyahi, Elin Stenfeldt, Jan Borén, Peter Carlsson, Ulf Smith, Juleen R Zierath, Margit Mahlapuu
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 2013

Pharmacological activation of AMPK suppresses inflammatory response evoked by IL-6 signalling in mouse liver and in human

hepatocytes

Annika Nerstedt, Emmelie Cansby, Manoj Amrutkar, Ulf Smith, Margit Mahlapuu
Molecular and Cellular Endocrinology - 2013

Serine/threonine protein kinase 25 (STK25): a novel negative regulator of lipid and glucose metabolism in rodent and human skeletal

muscle

Annika Nerstedt, Emmelie Cansby, Christian X Andersson, M. Laakso, A. Stancakova, M. Bluher, Ulf Smith, Margit Mahlapuu
Diabetologia - 2012

AMP-activated protein kinase inhibits IL-6-stimulated inflammatory response in human liver cells by suppressing phosphorylation of signal transducer and activator of transcription 3

(STAT3)

Annika Nerstedt, Aino Johansson, Christian X Andersson, Emmelie Cansby, Ulf Smith, Margit Mahlapuu
Diabetologia - 2010

Gene expression profiling identifies STAT3 as a novel pathway for immunomodulation by cholera toxin

adjuvant.

A Sjöblom-Hallén, Annika Nerstedt, Karin Schön, Lena Ekman, Peter Bergqvist, B Löwenadler, Nils Y Lycke
Mucosal immunology - 2010

Relationship between AMPK and the transcriptional balance of clock-related genes in skeletal

muscle

Elaine Vieira, Elisabeth C. Nilsson, Annika Nerstedt, Mattias Ormestad, Yun Chau Long, Pablo M. Garcia-Roves, Juleen R. Zierath, Margit Mahlapuu
American Journal of Physiology-Endocrinology and Metabolism - 2008

Epstein-Barr virus nuclear antigen 5 inhibits pre-mRNA cleavage and

polyadenylation.

Martin Dufva, Josefine Flodin, Annika Nerstedt, Ulla Rüetschi, Lars Rymo
Nucleic acids research - 2002

Response to cAMP levels of the Epstein-Barr virus EBNA2-inducible LMP1 oncogene and EBNA2 inhibition of a PP1-like

activity.

R Fåhraeus, Lars Palmqvist, Annika Nerstedt, Simin Farzad, Lars Rymo, Sonia Laín
The EMBO journal - 1994

Annika Nerstedt

Researcher

Publications