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Levent Akyürek

Professor/specialistläkare

Levent Akyürek
Professor/specialistläkare
Akademisk grad: Docent,
levent.akyurek@gu.se
031-786 3456

Postadress: Box 100, 40530 Göteborg
Besöksadress: Gula stråket 8 , 41345 Göteborg


Avdelningen för Laboratoriemedicin vid Institutionen för biomedicin (Mer information)
Sahlgrenska universitetssjukhuset
413 45 Göteborg
Besöksadress: Gula stråket 8 , 413 45 Göteborg

Om Levent Akyürek

Levent Akyürek is a vascular biologist in the field of angiogenesis during cardiovascular remodeling and tumor growth. Akyürek's early work defined the cellular interactions that stimulate the vasculoproliferative responses during transplant vasculopathy. These studies have indicated the important cellular determinants of neointima formation. Later, he examined neointimal smooth muscle and endothelial cell biology, both by inhibiting cellular proliferation using adenoviral gene therapy and by studying genes linked to cell cycle control.

His research activity has recently become focused on the involvement of filamins, a group of cytoskeleton proteins, in vascular cell signaling and transcription during the progression of cardiovascular and tumor diseases. Generation of filamin-deficient mouse models as well as mouse models to study the biological role of filamins during the progression of tumor growth and cardiovascular remodeling have been produced for the first time in his laboratory.

Dr. Akyürek graduated from the Medical School, Dokuz Eylül University, Turkey in 1989, and then completed his PhD program at Uppsala University in 1996. He worked as a postdoctoral fellow in the laboratory of Elizabeth G. Nabel at the University of Michigan and the National Institutes of Health, USA between 1997 and 2002. Dr. Akyürek became an Associate Professor of Cell Biology in 2004 and Professor in Pathology in 2014 at the University of Gothenburg. He currently acts as a reviewer on the editorial boards of several scientific journals in the field of vascular biology, transplantation immunology and molecular biology. He is also serving as clinical pathologist with expertise in molecular pathology at the Sahlgrenska Academy Hospital in Gothenburg.

Senaste publikationer

Pulmonary manifestations of systemic karyomegaly.
Levent Akyürek, Aziz Hussein, Andrew G Nicholson, Nils-Johan Mauritz, Johan Mölne
Respiratory Medicine Case Reports, Artikel i vetenskaplig tidskrift 2020
Artikel i vetenskaplig tidskrift

Targeting filamin A reduces macrophage activity and atherosclerosis.
Sashidar Bandaru, Chandu Ala, Reza Salimi, Murali K Akula, Matias Ekstrand et al.
Circulation, Artikel i vetenskaplig tidskrift 2019
Artikel i vetenskaplig tidskrift

Blocking the cleavage of filamin A by calpain inhibitor decreases tumor cell growth
Reza Salimi, Sashidar Bandaru, Sravani Devarakonda, Sevtap Gökalp, Chandu Ala et al.
Anticancer Research, Artikel i vetenskaplig tidskrift 2018
Artikel i vetenskaplig tidskrift

A review on traumatic diaphragmatic rupture
Joel Lundgren, SH Mousavie, AR Negahi, B Nakhaei, G Varga et al.
Trauma and Emergency Care, Artikel i vetenskaplig tidskrift 2017
Artikel i vetenskaplig tidskrift

Tidig forskningssatsning ger långsiktigt engagemang.
Puja Shahrouki, Åsa Torinsson Naluai, Agneta Ekman, Eric Hanse, Olle Larkö et al.
Läkartidningen, Artikel i övriga tidskrifter 2017
Artikel i övriga tidskrifter

Depletion of ATP and glucose in advanced human atherosclerotic plaques
Matias Ekstrand, Emma Widell, Anna Hammar, Levent Akyürek, Martin Johansson et al.
PLoS One, Artikel i vetenskaplig tidskrift 2017
Artikel i vetenskaplig tidskrift

Management of gunshot wounds in a scandinavian hospital
Joel Lundgren, SH Mousavie, AR Negahi, Levent Akyürek, Hans Granhed et al.
Trauma and Emergency Care, Artikel i vetenskaplig tidskrift 2017
Artikel i vetenskaplig tidskrift

Visar 21 - 30 av 40

2012

Targeting filamin A reduces K-RAS-induced lung adenocarcinomas and endothelial response to tumor growth in mice
Rajesh K. Nallapalli, Mohamed X Ibrahim, Xianghua Zhou, Sashidar Bandaru, Sai Naresh Sunkara et al.
Molecular Cancer, Artikel i vetenskaplig tidskrift 2012
Artikel i vetenskaplig tidskrift

2011

Filamin A mediates HGF/c-MET signaling in tumor cell migration.
Xianghua Zhou, Asli Toylu, Rajesh K. Nallapalli, Gisela M A Nilsson, Nese Atabey et al.
International journal of cancer. Journal international du cancer, Artikel i vetenskaplig tidskrift 2011
Artikel i vetenskaplig tidskrift

2010

Filamins in cell signaling, transcription and organ development.
Xianghua Zhou, John H Hartwig, Levent Akyürek
Trends in Cell Biology, Forskningsöversiktsartikel 2010
Forskningsöversiktsartikel

Deficiency of cyclin-dependent kinase inhibitors p21(Cip1) and p27(Kip1) accelerates atherogenesis in apolipoprotein E-deficient mice.
Levent Akyürek, Manfred Boehm, Michelle Olive, Xianghua Zhou, Hong San et al.
Biochemical and Biophysical Research Communications, Artikel i vetenskaplig tidskrift 2010
Artikel i vetenskaplig tidskrift

Cyclosporine does not reduce myocardial infarct size in a porcine ischemia-reperfusion model.
Lars O Karlsson, Xianghua Zhou, Erik Larsson, Karin Åström-Olsson, Chrichan Månsson et al.
Journal of Cardiovascular Pharmacology and Therapeutics, Artikel i vetenskaplig tidskrift 2010
Artikel i vetenskaplig tidskrift

Endothelial cells are activated during hypoxia via endoglin/ALK-1/SMAD1/5 signaling in vivo and in vitro.
Fei Tian, Xianghua Zhou, Anke M Smits, Erik Larsson, Marie-José Goumans et al.
Biochemical and Biophysical Research Communications, Forskningsöversiktsartikel 2010
Forskningsöversiktsartikel

A positive relationship between filamin and VEGF in patients with lung cancer
Hidetaka Uramoto, Levent Akyürek, T Hanagiri
Anticancer Research, Artikel i vetenskaplig tidskrift 2010
Artikel i vetenskaplig tidskrift

2009

Protein disulfide isomerase increases in myocardial endothelial cells in mice exposed to chronic hypoxia: a stimulatory role in angiogenesis.
Fei Tian, Xianghua Zhou, Johannes Wikström, Helen Karlsson, Helen Sjöland et al.
American Journal of Physiology. Heart and Circulatory Physiology, Artikel i vetenskaplig tidskrift 2009
Artikel i vetenskaplig tidskrift

Visar 21 - 30 av 40

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Utskriftsdatum: 2020-03-28