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- Margit Mahlapuu
Margit Mahlapuu
Professor
Institutionen för kemi ochOm Margit Mahlapuu
Our research combines studies in unique mouse models and well-characterized human cohorts with cellular and in vitro assays to provide insight into molecular pathogenesis and to find novel treatments targets for type 2 diabetes and related complex metabolic diseases with high unmet medical needs.
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Genetic Ablation of STE20-Type Kinase MST4 Does Not Alleviate Diet-Induced MASLD Susceptibility in
Mice
Mara Caputo, Emma Andersson, Ying Xia, Wei Hou, Emmelie Cansby, Max Erikson, Dan E. Lind, Bengt Hallberg, Manoj Amrutkar, Margit Mahlapuu
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - 2024 -
Silencing of STE20-type kinase TAOK1 confers protection against hepatocellular lipotoxicity through metabolic
rewiring
Ying Xia, Emma Andersson, Sumit Kumar Anand, Emmelie Cansby, Mara Caputo, Sima Kumari, R. Porosk, K. Kilk, S. Nair, Hanns-Ulrich Marschall, M. Blüher, Margit Mahlapuu
Hepatology communications. - 2023 -
STE20-type kinases MST3 and MST4 promote the progression of hepatocellular carcinoma: Evidence from human cell culture and expression profiling of liver
biopsies
Mara Caputo, Ying Xia, Sumit Kumar Anand, Emmelie Cansby, Emma Andersson, Hanns-Ulrich Marschall, A. Konigsrainer, A. Peter, Margit Mahlapuu
Faseb Journal - 2023 -
Knockout of STE20-type kinase TAOK3 does not attenuate diet-induced NAFLD development in
mice
Ying Xia, Emma Andersson, Mara Caputo, Emmelie Cansby, Francesca Sedda, F. Font-Girones, Johan Ruud, Yeshwant Kurhe, Bengt Hallberg, Hanns-Ulrich Marschall, Ingrid Wernstedt Asterholm, Stefano Romeo, M. Blüher, Margit Mahlapuu
Molecular Medicine - 2023 -
Silencing of STE20-type kinase STK25 in human aortic endothelial and smooth muscle cells is
atheroprotective
Emmelie Cansby, Sima Kumari, Mara Caputo, Ying Xia, Rando Porosk, Jonathan Robinson, Hao Wang, Britt-Marie Olsson, Josefine Vallin, Julie Grantham, Ursel Soomets, L. Thomas Svensson, Carina Sihlbom, Hanns-Ulrich Marschall, Andreas Edsfeldt, Isabel Goncalves, Margit Mahlapuu
Communications Biology - 2022 -
Inhibition of MAP4K4 signaling initiates metabolic reprogramming to protect hepatocytes from lipotoxic
damage
Sumit Kumar Anand, Mara Caputo, Ying Xia, Emma Andersson, Emmelie Cansby, Sima Kumari, Marcus Henricsson, R. Porosk, Katharina Keuenhof, Johanna L Höög, Syam Nair, Hanns-Ulrich Marschall, M. Bluher, Margit Mahlapuu
Journal of Lipid Research - 2022 -
GCKIII kinases in lipotoxicity: Roles in NAFLD and
beyond
Margit Mahlapuu, Mara Caputo, Ying Xia, Emmelie Cansby
Hepatology communications - 2022 -
Antagonizing STK25 Signaling Suppresses the Development of Hepatocellular Carcinoma Through Targeting Metabolic, Inflammatory, and Pro-Oncogenic
Pathways
Yeshwant Kurhe, Mara Caputo, Emmelie Cansby, Ying Xia, Sima Kumari, Sumit Kumar Anand, B. W. Howell, Hanns-Ulrich Marschall, Margit Mahlapuu
Cellular and Molecular Gastroenterology and Hepatology - 2022 -
Silencing of STE20-type kinase MST3 in mice with antisense oligonucleotide treatment ameliorates diet-induced nonalcoholic fatty liver
disease
Mara Caputo, Yeshwant Kurhe, Sima Kumari, Emmelie Cansby, M. Amrutkar, E. Scandalis, S. L. Booten, Marcus Ståhlman, Jan Borén, Hanns-Ulrich Marschall, M. Aghajan, Margit Mahlapuu
FASEB Journal - 2021 -
STE20-type kinase TAOK3 regulates hepatic lipid
partitioning
Ying Xia, Mara Caputo, Emmelie Cansby, Sumit Kumar Anand, Silva Sütt, Marcus Henricsson, R. Porosk, H. U. Marschall, M. Bluher, Margit Mahlapuu
Molecular Metabolism - 2021 -
STE20-Type Protein Kinase MST4 Controls NAFLD Progression by Regulating Lipid Droplet Dynamics and Metabolic Stress in
Hepatocytes
Mara Caputo, Emmelie Cansby, Sima Kumari, Yeshwant Kurhe, Syam Nair, Marcus Ståhlman, Nagaraj M. Kulkarni, Jan Borén, Hanns-Ulrich Marschall, M. Bluher, Margit Mahlapuu
Hepatology Communications - 2021 -
Depletion of protein kinase STK25 ameliorates renal lipotoxicity and protects against diabetic kidney
disease.
Emmelie Cansby, Mara Caputo, Lei Gao, Nagaraj M. Kulkarni, Annika Nerstedt, Marcus Ståhlman, Jan Borén, Rando Porosk, Ursel Soomets, Matteo Pedrelli, Paolo Parini, Hanns-Ulrich Marschall, Jenny Nyström, Brian W Howell, Margit Mahlapuu
JCI insight - 2020 -
Lipid droplet-associated kinase STK25 regulates peroxisomal activity and metabolic stress response in steatotic
liver
Annika Nerstedt, Yeshwant Kurhe, Emmelie Cansby, Mara Caputo, Lei Gao, Egor Vorontsov, Marcus Ståhlman, Esther Nuñez Durán, Jan Borén, Hanns-Ulrich Marschall, Douglas G. Mashek, D. N. Saunders, Carina Sihlbom, A. J. Hoy, Margit Mahlapuu
Journal of Lipid Research - 2020 -
Protein kinase MST3 modulates lipid homeostasis in hepatocytes and correlates with nonalcoholic steatohepatitis in
humans.
Emmelie Cansby, Nagaraj M. Kulkarni, Elin Magnusson, Yeshwant Kurhe, Manoj Amrutkar, Annika Nerstedt, Marcus Ståhlman, Carina Sihlbom, Hanns-Ulrich Marschall, Jan Borén, Matthias Blüher, Margit Mahlapuu
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 2019 -
Cubosomes for topical delivery of the antimicrobial peptide
LL-37
L. Boge, K. Hallstensson, L. Ringstad, J. Johansson, T. Andersson, M. Davoudi, P. T. Larsson, Margit Mahlapuu, J. Håkansson, M. Andersson
European Journal of Pharmaceutics and Biopharmaceutics - 2019 -
Targeted Delivery of Stk25 Antisense Oligonucleotides to Hepatocytes Protects Mice Against Nonalcoholic
Fatty Liver Disease.
Emmelie Cansby, Esther Nuñez Durán, Elin Magnusson, Manoj Amrutkar, Sheri L Booten, Nagaraj M. Kulkarni, L Thomas Svensson, Jan Borén, Hanns-Ulrich Marschall, Mariam Aghajan, Margit Mahlapuu
Cellular and molecular gastroenterology and hepatology - 2019 -
Antimicrobial synergy of monolaurin lipid nanocapsules with adsorbed antimicrobial peptides against Staphylococcus aureus biofilms in vitro is absent in
vivo.
Linzhu Su, Anita Umerska, Matthieu Eveillard, Joakim Håkansson, Margit Mahlapuu, Fan Huang, Jianfeng Liu, Zhenkun Zhang, Linqi Shi, Henny C van der Mei, Henk J Busscher, Prashant K Sharma
Journal of controlled release : official journal of the Controlled Release Society - 2019 -
Characterization of the in vitro, ex vivo, and in vivo Efficacy of the Antimicrobial Peptide DPK-060 Used for Topical
Treatment.
Joakim Håkansson, Lovisa Ringstad, Anita Umerska, Jenny Johansson, Therese Andersson, Lukas Boge, René T Rozenbaum, Prashant K Sharma, Petter Tollbäck, Camilla Björn, Patrick Saulnier, Margit Mahlapuu
Frontiers in cellular and infection microbiology - 2019 -
STK25 Regulates Cardiovascular Disease Progression in a Mouse Model of
Hypercholesterolemia
Emmelie Cansby, Elin Magnusson, Esther Nuñez Durán, M. Amrutkar, M. Pedrelli, P. Parini, Jenny M Hoffmann, Marcus Ståhlman, B. W. Howell, Hanns-Ulrich Marschall, Jan Borén, Margit Mahlapuu
Arteriosclerosis Thrombosis and Vascular Biology - 2018 -
STK25 regulates oxidative capacity and metabolic efficiency in adipose
tissue
Silva Sütt, Emmelie Cansby, A. Paul, M. Amrutkar, Esther Nuñez Durán, Nagaraj M. Kulkarni, M. Ståhlman, J. Borén, J. Laurencikiene, B. W. Howell, Sven Enerbäck, Margit Mahlapuu
Journal of Endocrinology - 2018 -
Serine/threonine protein kinase 25 antisense oligonucleotide treatment reverses glucose intolerance, insulin resistance, and nonalcoholic fatty liver disease in
mice.
Esther Nuñez Durán, Mariam Aghajan, Manoj Amrutkar, Silva Sütt, Emmelie Cansby, Sheri L Booten, Andrew Watt, Marcus Ståhlman, Norbert Stefan, Hans-Ulrich Häring, Harald Staiger, Jan Borén, Hanns-Ulrich Marschall, Margit Mahlapuu
Hepatology communications - 2018 -
Protein kinase STK25 aggravates the severity of non-alcoholic fatty pancreas disease in
mice
Esther Nuñez Durán, Belén Chanclón, Silva Sütt, Joana Real, Hanns-Ulrich Marschall, Ingrid Wernstedt Asterholm, Emmelie Cansby, Margit Mahlapuu
Journal of Endocrinology - 2017 -
Overexpression of protein kinase STK25 in mice exacerbates ectopic lipid accumulation, mitochondrial dysfunction and insulin resistance in skeletal
muscle.
Urszula Chursa, Esther Nuñez Durán, Emmelie Cansby, Manoj Amrutkar, Silva Sütt, Marcus Ståhlman, Britt-Marie Olsson, Jan Borén, Maria Johansson, Fredrik Bäckhed, Bengt R Johansson, Carina Sihlbom, Margit Mahlapuu
Diabetologia - 2017 -
FGF21 signaling - the liver in
focus.
Margit Mahlapuu, Hanns-Ulrich Marschall
Hepatology (Baltimore, Md.) - 2016 -
STK25 is a critical determinant in nonalcoholic
steatohepatitis.
Manoj Amrutkar, Urszula Chursa, Matthias Kern, Esther Nuñez Durán, Marcus Ståhlman, Silva Sütt, Jan Borén, Bengt R Johansson, Hanns-Ulrich Marschall, Matthias Blüher, Margit Mahlapuu
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 2016 -
Anti-infective efficacy of the lactoferrin-derived antimicrobial peptide
HLR1r
Camilla Björn, Margit Mahlapuu, Inger Mattsby-Baltzer, J. Hakansson
Peptides - 2016 -
Protein kinase STK25 controls lipid partitioning in hepatocytes and correlates with liver fat content in
humans
Manoj Amrutkar, M. Kern, Esther Nuñez Durán, Marcus Ståhlman, Emmelie Cansby, Urszula Chursa, Elin Stenfeldt, Jan Borén, M. Bluher, Margit Mahlapuu
Diabetologia - 2016 -
Antimicrobial Peptides : An Emerging Category of Therapeutic
Agents
Margit Mahlapuu, J. Hakansson, L. Ringstad, Camilla Björn
Frontiers in Cellular and Infection Microbiology - 2016 -
Genetic Disruption of Protein Kinase STK25 Ameliorates Metabolic Defects in a Diet-Induced Type 2 Diabetes
Model
Manoj Amrutkar, Emmelie Cansby, Urszula Chursa, Esther Nuñez Durán, Belén Chanclón, Marcus Ståhlman, Vincent Fridén, Louise Mannerås Holm, Anna Wickman, Ulf Smith, Fredrik Bäckhed, Jan Borén, B. W. Howell, Margit Mahlapuu
Diabetes - 2015 -
Protein kinase STK25 regulates hepatic lipid partitioning and progression of liver steatosis and
NASH
Manoj Amrutkar, Emmelie Cansby, Esther Nuñez Durán, Carlo Pirazzi, Marcus Ståhlman, Elin Stenfeldt, Ulf Smith, Jan Borén, Margit Mahlapuu
Faseb Journal - 2015 -
Efficacy and safety profile of the novel antimicrobial peptide PXL150 in a mouse model of infected burn
wounds
Camilla Björn, L. Noppa, E. N. Salomonsson, A. L. Johansson, E. Nilsson, Margit Mahlapuu, J. Hakansson
International Journal of Antimicrobial Agents - 2015 -
PXL01 in Sodium Hyaluronate for Improvement of Hand Recovery after Flexor Tendon Repair Surgery: Randomized Controlled
Trial.
Monica E Wiig, Lars B Dahlin, Jan Fridén, Lars Hagberg, Sören E Larsen, Kerstin Wiklund, Margit Mahlapuu
PloS one - 2014 -
Partial hepatic resistance to IL-6-induced inflammation develops in type 2 diabetic mice, while the anti-inflammatory effect of AMPK is
maintained
Emmelie Cansby, Annika Nerstedt, Manoj Amrutkar, Esther Nuñez Durán, Ulf Smith, Margit Mahlapuu
Molecular and Cellular Endocrinology - 2014 -
Increased expression of STK25 leads to impaired glucose utilization and insulin sensitivity in mice challenged with a high-fat
diet.
Emmelie Cansby, Manoj Amrutkar, Louise Mannerås Holm, Annika Nerstedt, Azadeh Reyahi, Elin Stenfeldt, Jan Borén, Peter Carlsson, Ulf Smith, Juleen R Zierath, Margit Mahlapuu
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 2013 -
Pharmacological activation of AMPK suppresses inflammatory response evoked by IL-6 signalling in mouse liver and in human
hepatocytes
Annika Nerstedt, Emmelie Cansby, Manoj Amrutkar, Ulf Smith, Margit Mahlapuu
Molecular and Cellular Endocrinology - 2013 -
Effect of lactoferrin peptide (PXL01) on rabbit digital mobility after flexor tendon
repair
Joakim Håkansson, Margit Mahlapuu, Lars Ekström, Kjell Olmarker, Wiig Monica
Journal of Hand Surgery-American Volume - 2012 -
Serine/threonine protein kinase 25 (STK25): a novel negative regulator of lipid and glucose metabolism in rodent and human skeletal
muscle
Annika Nerstedt, Emmelie Cansby, Christian X Andersson, M. Laakso, A. Stancakova, M. Bluher, Ulf Smith, Margit Mahlapuu
Diabetologia - 2012 -
A lactoferrin-derived peptide (PXL01) for the reduction of adhesion formation in flexor tendon surgery: an experimental study in
rabbits
M. Wiig, Kjell Olmarker, J. Hakansson, Lars Ekström, Elin Nilsson, Margit Mahlapuu
J Hand Surg Eur Vol - 2011 -
Model for assessment of mobility of toes and healing of tendons in
rabbits.
Kjell Olmarker, Lars Ekström, Joakim Håkansson, Elin Nilsson, Monica Wiig, Margit Mahlapuu
Journal of plastic surgery and hand surgery - 2010 -
AMP-activated protein kinase inhibits IL-6-stimulated inflammatory response in human liver cells by suppressing phosphorylation of signal transducer and activator of transcription 3
(STAT3)
Annika Nerstedt, Aino Johansson, Christian X Andersson, Emmelie Cansby, Ulf Smith, Margit Mahlapuu
Diabetologia - 2010 -
A novel polypeptide derived from human lactoferrin in sodium hyaluronate prevents postsurgical adhesion formation in the
rat.
Elin Nilsson, Camilla Björn, Veronika Sjöstrand, Kerstin Lindgren, Mattias Münnich, Inger Mattsby-Baltzer, Marie-Louise Ivarsson, Kjell Olmarker, Margit Mahlapuu
Annals of surgery - 2009 -
Relationship between AMPK and the transcriptional balance of clock-related genes in skeletal
muscle
Elaine Vieira, Elisabeth C. Nilsson, Annika Nerstedt, Mattias Ormestad, Yun Chau Long, Pablo M. Garcia-Roves, Juleen R. Zierath, Margit Mahlapuu
American Journal of Physiology-Endocrinology and Metabolism - 2008 -
Osteoporosis in MCHR1-deficient
mice.
Mohammad Bohlooly-Yeganeh, Margit Mahlapuu, Harriet Andersén, Annika Astrand, Stephan Hjorth, Lennart Svensson, Jan Törnell, Michael R Snaith, David G Morgan, Claes Ohlsson
Biochemical and biophysical research communications - 2004 -
Mice lacking melanin-concentrating hormone receptor 1 demonstrate increased heart rate associated with altered autonomic
activity.
Annika Astrand, Mohammad Bohlooly-Yeganeh, Sara Larsdotter, Margit Mahlapuu, Harriet Andersén, Jan Tornell, Claes Ohlsson, Mike Snaith, David G A Morgan
American journal of physiology. Regulatory, integrative and comparative physiology - 2004