Michael Lebens
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A New Strategy Toward B Cell-Based Cancer Vaccines by Active Immunization With Mimotopes of Immune Checkpoint
Inhibitors
J. Tobias, C. Battin, A. D. Linhares, Michael Lebens, K. Baier, K. Ambroz, M. Drinic, S. Hogler, A. Inic-Kanada, E. Garner-Spitzer, M. Preusser, L. Kenner, M. Kundi, C. C. Zielinski, P. Steinberger, U. Wiedermann
Frontiers in Immunology - 2020-01-01 -
Alpha-galactosylceramide enhances mucosal immunity to oral whole-cell cholera
vaccines
C. J. H. Davitt, S. Longet, A. Albutti, V. Aversa, Stefan Nordqvist, B. Hackett, C. P. McEntee, M. Rosa, I. S. Coulter, Michael Lebens, Joshua Tobias, Jan Holmgren, E. C. Lavelle
Mucosal Immunology - 2019-01-01 -
Proteomic analysis of cholera toxin adjuvant-stimulated human monocytes identifies Thrombospondin-1 and Integrin-beta 1 as strongly upregulated molecules involved in adjuvant
activity
Manuela Terrinoni, Jan Holmgren, Michael Lebens, Maximilian Larena
Scientific Reports - 2019-01-01 -
Requirement for Cyclic AMP/Protein Kinase A-Dependent Canonical NF kappa B Signaling in the Adjuvant Action of Cholera Toxin and Its Non-toxic Derivative
mmCT
Manuela Terrinoni, Jan Holmgren, Michael Lebens, Maximilian Larena
Frontiers in Immunology - 2019-01-01 -
GM1 ganglioside-independent intoxication by Cholera
toxin
Jakob Cervin, Amberlyn M Wands, Anna Casselbrant, Han Wu, Soumya Krishnamurthy, Aleksander Cvjetkovic, Johanna Estelius, Benjamin Dedic, Anirudh Sethi, Kerri-Lee Wallom, Rebecca E Riise, Malin Bäckström, Ville Wallenius, Frances M Platt, Michael Lebens, Susann Teneberg, Lars Fändriks, Jennifer J Kohler, Ulf Yrlid
PLoS Pathogens - 2018-01-01 -
B cells treated with CTB-p210 acquire a regulatory phenotype in vitro and reduce atherosclerosis in apolipoprotein E deficient
mice
S. Rattik, P. T. Mantani, I. Y. Mattisson, I. Ljungcrantz, L. Sundius, H. Bjorkbacka, Manuela Terrinoni, Michael Lebens, Jan Holmgren, J. Nilsson, M. Wigren, G. N. Fredrikson
Vascular Pharmacology - 2018-01-01 -
Preclinical immunogenicity and protective efficacy of an oral Helicobacter pylori inactivated whole cell vaccine and multiple mutant cholera toxin: A novel and non-toxic mucosal
adjuvant
Jan Holmgren, Stefan Nordqvist, Margareta Blomquist, Frida Jeverstam, Michael Lebens, Sukanya Raghavan
Vaccine - 2018-01-01 -
A Novel Nonantibiotic, lgt-Based Selection System for Stable Maintenance of Expression Vectors in Escherichia coli and Vibrio
cholerae
Manuela Terrinoni, Stefan Nordqvist, Susanne Källgård, Jan Holmgren, Michael Lebens
Applied and Environmental Microbiology - 2018-01-01 -
Surface expression of Helicobacter pylori HpaA adhesion antigen on Vibrio cholerae, enhanced by co-expressed enterotoxigenic Escherichia coli fimbrial
antigens
Joshua Tobias, Michael Lebens, S. N. Wai, Jan Holmgren, Ann-Mari Svennerholm
Microbial Pathogenesis - 2017-01-01 -
Biochemical and structural characterization of the novel sialic acid-binding site of Escherichia coli heat-labile enterotoxin
LT-IIb.
Dani Zalem, João P Ribeiro, Annabelle Varrot, Michael Lebens, Anne Imberty, Susann Teneberg
The Biochemical journal - 2016-01-01 -
Retrospective Analysis of Serotype Switching of Vibrio cholerae O1 in a Cholera Endemic Region Shows It Is a Non-random
Process
Stefan L. Karlsson, N. Thomson, A. Mutreja, T. Connor, D. Sur, M. Ali, J. Clemens, G. Dougan, Jan Holmgren, Michael Lebens
Plos Neglected Tropical Diseases - 2016-01-01 -
Construction and preclinical evaluation of mmCT, a novel mutant cholera toxin adjuvant that can be efficiently produced in genetically manipulated Vibrio
cholerae
Michael Lebens, Manuela Terrinoni, Stefan L. Karlsson, Maximilian Larena, Tobias Gustafsson-Hedberg, Susanne Källgård, Erik Nygren, Jan Holmgren
Vaccine - 2016-01-01 -
Cholera toxin, and the related nontoxic adjuvants mmCT and dmLT, promote human Th17 responses via cyclic AMP-protein kinase A and inflammasome-dependent IL-1
signaling
Maximilian Larena, Jan Holmgren, Michael Lebens, Manuela Terrinoni, Anna Lundgren
Journal of Immunology - 2015-01-01 -
Development of Stable Vibrio cholerae O1 Hikojima Type Vaccine Strains Co-Expressing the Inaba and Ogawa Lipopolysaccharide
Antigens
Stefan Karlsson, Elisabeth Ax, Erik Nygren, Susanne Källgård, Margareta Blomquist, Annelie Ekman, John Benktander, Jan Holmgren, Michael Lebens
Plos One - 2014-01-01 -
The Repertoire of Glycosphingolipids Recognized by Vibrio
cholerae
John Benktander, Jonas Ångström, Hasse Karlsson, Omid Teymournejad, Sara K. Lindén, Michael Lebens, Susann Teneberg
Plos One - 2013-01-01 -
Evidence for several waves of global transmission in the seventh cholera
pandemic.
Ankur Mutreja, DW Kim, Nicholas Thomson, TR Connor, JH Lee, S Kariuki, NJ Croucher, SY Choi, SR Harris, Michael Lebens, SK Niyogi, EJ Kim, T Ramamurthy, J Chun, JL Wood, JD Clemens, Cecil Czerkinsky, GB Nair, Jan Holmgren, Julian Parkhill, Gordon Dougan
Nature - 2012-01-01 -
Crystal structures exploring the origins of the broader specificity of Escherichia coli heat-labile enterotoxin compared to cholera
toxi
Åsa Holmner, A Mackenzie, Mats Ökvist, Lena Jansson, Michael Lebens, Susann Teneberg, Ute Krengel
Journal of Molecular Biology - 2011-01-01 -
Construction of novel vaccine strains of Vibrio cholerae co-expressing the Inaba and Ogawa serotype
antigens.
Michael Lebens, Stefan Karlsson, Susanne Källgård, Margareta Blomqvist, Annelie Ekman, Erik Nygren, Jan Holmgren
Vaccine - 2011-01-01 -
Construction of a non-toxigenic Escherichia coli oral vaccine strain expressing large amounts of CS6 and inducing strong intestinal and serum anti-CS6 antibody responses in
mice.
Joshua Tobias, Ann-Mari Svennerholm, Nils I A Carlin, Michael Lebens, Jan Holmgren
Vaccine - 2011-01-01 -
Crystal Structures Exploring the Origins of the Broader Specificity of Escherichia coli Heat-Labile Enterotoxin Compared to Cholera
Toxin.
Åsa Holmner, Alasdair Mackenzie, Mats Ökvist, Lena Jansson, Michael Lebens, Susann Teneberg, Ute Krengel
Journal of molecular biology - 2011-01-01 -
Intranasal Immunization With an Apolipoprotein B-100 Fusion Protein Induces Antigen-Specific Regulatory T Cells and Reduces
Atherosclerosis
Roland Klingenberg, Michael Lebens, Andreas Hermansson, Gunilla Nordin Fredrikson, Daniela Strodthoff, Mats Rudling, Daniel F. J. Ketelhuth, Norbert Gerdes, Jan Holmgren, Jan Nilsson, Goran K. Hansson
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY - 2010-01-01 -
Construction and expression of immunogenic hybrid enterotoxigenic Escherichia coli CFA/I and CS2 colonization fimbriae for use in
vaccines.
Joshua Tobias, Ann-Mari Svennerholm, Jan Holmgren, Michael Lebens
Applied microbiology and biotechnology - 2010-01-01 -
Over-expression of major colonization factors of enterotoxigenic Escherichia coli, alone or together, on non-toxigenic E. coli
bacteria.
Joshua Tobias, Jan Holmgren, Maria Hellman, Erik Nygren, Michael Lebens, Ann-Mari Svennerholm
Vaccine - 2010-01-01 -
Carbohydrate binding specificities and crystal structure of the cholera toxin-like B-subunit from Citrobacter
freundii.
Lena Jansson, Jonas Angström, Michael Lebens, Anne Imberty, Annabelle Varrot, Susann Teneberg
Biochimie - 2010-01-01 -
Sulfatide recognition by colonization factor antigen CS6 from enterotoxigenic Escherichia
coli.
Lena Jansson, Joshua Tobias, Catharina Jarefjäll, Michael Lebens, Ann-Mari Svennerholm, Susann Teneberg
PloS one - 2009-01-01 -
CD4+ T-cell responses to an oral inactivated cholera vaccine in young children in a cholera endemic country and the enhancing effect of zinc
supplementation.
Tanvir Ahmed, Mohammad Arifuzzaman, Michael Lebens, Firdausi Qadri, Anna Lundgren
Vaccine - 2009-01-01 -
No direct binding of the heat-labile enterotoxin of Escherichia coli to E. coli
lipopolysaccharides.
Lena Jansson, Jonas Ångström, Michael Lebens, Susann Teneberg
Glycoconjugate journal - 2009-01-01 -
Mutations in the periplasmic chaperone leading to loss of surface expression of the colonization factor CS6 in enterotoxigenic Escherichia coli (ETEC) clinical
isolates.
Matilda Nicklasson, Åsa Sjöling, Michael Lebens, Joshua Tobias, Anders Janzon, Lars Brive, Ann-Mari Svennerholm
Microbial Pathogenesis - 2008-01-01 -
Construction of non-toxic Escherichia coli and Vibrio cholerae strains expressing high and immunogenic levels of enterotoxigenic E. coli colonization factor I
fimbriae.
Joshua Tobias, Michael Lebens, Ingrid Bölin, Gudrun Wiklund, Ann-Mari Svennerholm
Vaccine - 2008-01-01 -
Role of different genes in the CS6 operon for surface expression of Enterotoxigenic Escherichia coli colonization factor
CS6.
Joshua Tobias, Michael Lebens, Susanne Källgård, Matilda Nicklasson, Ann-Mari Svennerholm
Vaccine - 2008-01-01 -
The major subunit, CfaB, of colonization factor antigen i from enterotoxigenic Escherichia coli is a glycosphingolipid binding
protein.
Lena Jansson, Joshua Tobias, Michael Lebens, Ann-Mari Svennerholm, Susann Teneberg
Infection and immunity - 2006-01-01 -
Oral tolerance induction by mucosal administration of cholera toxin B-coupled antigen involves T-cell proliferation in vivo and is not affected by depletion of CD25+ T
cells.
Annie George-Chandy, Susanne Hultkrantz, Sukanya Raghavan, Cecil Czerkinsky, Michael Lebens, Esbjörn Telemo, Jan Holmgren
Immunology - 2006-01-01 -
Mucosal adjuvants based on cholera toxin and Escherichia Coli heat-labile
enterotoxin.
Jan Holmgren, Cecil Czerkinsky, Ali M Harandi, Michael Lebens, Jia-Bin Sun
- 2006-01-01 -
Mucosal adjuvants and anti-infection and anti-immunopathology vaccines based on cholera toxin, cholera toxin B subunit and CpG
DNA
Jan Holmgren, Jenni Adamsson, F. Anjuere, J. Clemens, C. Czerkinsky, Kristina Eriksson, Carl-Fredrik Flach, Annie George-Chandy, Ali M Harandi, Michael Lebens, T. Lehner, Marianne Lindblad, Erik Nygren, Sukanya Raghavan, Joaquin Sanchez, M. Stanford, Jia-Bin Sun, Ann-Mari Svennerholm, Sara Tengvall
Immunol Lett - 2005-01-01 -
Novel binding site identified in a hybrid between cholera toxin and heat-labile enterotoxin: 1.9 A crystal structure reveals the
details.
Åsa Holmner, Michael Lebens, Susann Teneberg, Jonas Ångström, Mats Ökvist, Ute Krengel
Structure (London, England : 1993) - 2004-01-01 -
In vivo adjuvant-induced mobilization and maturation of gut dendritic cells after oral administration of cholera
toxin
Fabienne Anjuère, Carmelo Luci, Michael Lebens, Déborah Rousseau, Catherine Hervouet, Geneviève Milon, Jan Holmgren, Carlos Ardavin, Cecil Czerkinsky
Journal of Immunology - 2004-01-01