Lotta Agholme
Om Lotta Agholme
In our group, we are studying the pahtopysiology of Alzheimer's diseae using human neuronal cell models, primarily iSPC-derived cortical neurons. Our group is also studying the endogenous function of the Alzheimer-related proteins APP and Amyloid-Beta.
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Herpes Simplex Virus 1 and 2 Infections during Differentiation of Human Cortical
Neurons
Petra Bergström, Edward Trybala, Charlotta Eriksson, Maria Johansson, Tugce Munise Satir, Sibylle Widehn, Stefanie Fruhwürth, W. Michno, Faisal Hayat Nazir, Jörg Hanrieder, Sören R Paludan, Lotta Agholme, Henrik Zetterberg, Tomas Bergström
Viruses-Basel - 2021-01-01 -
Bi-allelic VPS16 variants limit HOPS/CORVET levels and cause a mucopolysaccharidosis-like
disease.
Kalliopi Sofou, Kolja Meier, Leslie E Sanderson, Debora Kaminski, Laia Montoliu-Gaya, Emma Samuelsson, Maria K. Blomqvist, Lotta Agholme, Jutta Gärtner, Chris Mühlhausen, Niklas Darin, Tahsin Stefan Barakat, Lars Schlotawa, Tjakko van Ham, Jorge Asin-Cayuela, Fredrik H Sterky
EMBO molecular medicine - 2021-01-01 -
Accelerated neuronal and synaptic maturation by BrainPhys medium increases Aβ secretion and alters Aβ peptide ratios from iPSC-derived cortical
neurons.
Tugce Munise Satir, Faisal Hayat Nazir, Dzeneta Vizlin-Hodzic, Erik Hardselius, Kaj Blennow, S. Wray, Henrik Zetterberg, Lotta Agholme, Petra Bergström
Scientific reports - 2020-01-01 -
Partial reduction of amyloid β production by β-secretase inhibitors does not decrease synaptic
transmission
Tugce Munise Satir, Lotta Agholme, A. Karlsson, M. Karlsson, P. Karila, S. Illes, Petra Bergström, Henrik Zetterberg
Alzheimer's Research and Therapy - 2020-01-01 -
Brain immune cells undergo cGAS-STING-dependent apoptosis during herpes simplex virus type 1
infection.
Line S Reinert, Ahmad S Rashidi, Diana N Tran, Georgios Katzilieris-Petras, Astrid K Hvidt, Mette Gohr, Stefanie Fruhwürth, Chiranjeevi Bodda, Martin K Thomsen, Mikkel H Vendelbo, Ahmad Raza Khan, Brian Hansen, Petra Bergström, Lotta Agholme, Trine H Mogensen, Maria H Christensen, Jens R Nyengaard, Ganes C Sen, Henrik Zetterberg, Georges Mgm Verjans, Soren R Paluden
The Journal of clinical investigation - 2020-01-01 -
Tauopathy-Associated Tau Fragment Ending at Amino Acid 224 Is Generated by Calpain-2
Cleavage.
Claudia Cicognola, Tugce Munise Satir, Gunnar Brinkmalm, Irena Matečko-Burmann, Lotta Agholme, Petra Bergström, Bruno Becker, Henrik Zetterberg, Kaj Blennow, Kina Höglund
Journal of Alzheimer's disease : JAD - 2020-01-01 -
HSV1 VP1-2 deubiquitinates STING to block type I interferon expression and promote brain
infection
C. Bodda, L. S. Reinert, Stefanie Fruhwürth, T. Richardo, C. Sun, B. C. Zhang, M. Kalamvoki, A. Pohlmann, T. H. Mogensen, Petra Bergström, Lotta Agholme, P. O'Hare, B. Sodeik, M. Gyrd-Hansen, Henrik Zetterberg, Sören R Paludan
The Journal of experimental medicine - 2020-01-01 -
Author Correction: Accelerated neuronal and synaptic maturation by BrainPhys medium increases Aβ secretion and alters Aβ peptide ratios from iPSC-derived cortical
neurons.
Tugce Munise Satir, Faisal Hayat Nazir, Dzeneta Vizlin-Hodzic, Erik Hardselius, Kaj Blennow, Selina Wray, Henrik Zetterberg, Lotta Agholme, Petra Bergström
Scientific reports - 2020-01-01 -
Expression and secretion of synaptic proteins during stem cell differentiation to cortical
neurons.
Faisal Hayat Nazir, Bruno Becker, Ann Brinkmalm, Kina Höglund, Åsa P Sandelius, Petra Bergström, Tugce Munise Satir, Annika Öhrfelt, Kaj Blennow, Lotta Agholme, Henrik Zetterberg
Neurochemistry international - 2018-01-01 -
Low-dose γ-secretase inhibition increases secretion of Aβ peptides and intracellular oligomeric
Aβ.
Lotta Agholme, Marcus Clarin, Eleni Gkanatsiou, Petronella Kettunen, Jasmine Chebli, Gunnar Brinkmalm, Kaj Blennow, Petra Bergström, Erik Portelius, Henrik Zetterberg
Molecular and cellular neurosciences - 2017-01-01 -
Amyloid precursor protein expression and processing are differentially regulated during cortical neuron
differentiation
Petra Bergström, Lotta Agholme, Faisal Hayat Nazir, Tugce Munise Satir, J. Toombs, H. Wellington, Joakim Strandberg, Thomas Olsson Bontell, Hlin Kvartsberg, Maria Holmström, Cecilia Boreström, Stina Simonsson, T. Kunath, Anders Lindahl, Kaj Blennow, Eric Hanse, Erik Portelius, S. Wray, Henrik Zetterberg
Scientific Reports - 2016-01-01 -
Aggregated Alpha-Synuclein Transfer Efficiently between Cultured Human Neuron-Like Cells and Localize to
Lysosomes
J. Domert, C. Sackmann, E. Severinsson, Lotta Agholme, J. Bergstrom, M. Ingelsson, M. Hallbeck
Plos One - 2016-01-01 -
Lysosomal Network Proteins as Potential Novel CSF Biomarkers for Alzheimer's
Disease.
Andrea Armstrong, Niklas Mattsson, Hanna Appelqvist, Camilla Janefjord, Linnea Sandin, Lotta Agholme, Bob Olsson, Samuel Svensson, Kaj Blennow, Henrik Zetterberg, Katarina Kågedal
Neuromolecular medicine - 2013-01-01