Göteborgs universitet
Göteborgs universitet
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  4. Frida Gorreja

Frida Gorreja

Doktorand

Avd för mikrobiologi och
immunologi
E-post
frida.gorreja@gu.se
Besöksadress
Medicinaregatan 7 a
41390 Göteborg
Postadress
Box 435
40530 Göteborg

Om Frida Gorreja

Macrophages are predominant innate immue cells that can be found throughout our bodies, including in the human gastrointestinal tract. Inflammatory and tissue resident macrophages contribute to the pathogenesis of Inflammatory Bowel Diseases such as Crohn´s Disease. Once microbiota or pathogenic bacteria passes through the damaged intestinal barrier and activates macrophages they release pro-inflammatory and anti-inflammatory proteins/cytokines such as interleukin-1 beta (IL-1β), IL-10, tumor necrosis factor-α (TNF-α) and transforming growth factor-β (TGF-β). Such homeostatic balance or pro-inflammatory and anti-inflammatory proteins, and the involvement of specific macrophage subtypes producing them, is imparied in Crohn´s Disease.

My research focuses in studying the macrophage phenotype and funtion in Crohn´s Disease with regards to microbiota involvement, disease location and disease subtypes. More information on my teams work can be found here https://www.gu.se/forskning/lena-ohman