Stephan Lange
Om Stephan Lange
My laboratory investigates muscle development, signaling and maintenance, by studying the biological role of sarcomeric and muscle associated proteins. I am particularly interested to decipher molecular mechanisms that play a role in the development of cardiac and skeletal muscle myopathies.
Other affiliations:
Associate Professor University of California San Diego, School of Medicine 9500 Gilman Dr., BRF2 # 1243-Q, La Jolla, CA-92093, USA
Lab Website: slangelab.ucsd.edu
Full list of publications: www.ncbi.nlm.nih.gov/sites/myncbi/stephan.lange.1/bibliography/41494144/public/
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Molecular Characterisation of Titin N2A and Its Binding of CARP Reveals a Titin/Actin Cross-linking
Mechanism
T. K. Zhou, J. R. Fleming, Stephan Lange, A. L. Hessel, J. Bogomolovas, C. Stronczek, D. Grundei, M. Ghassemian, A. Biju, Emma Börgeson, B. Bullard, W. A. Linke, J. Chen, M. Kovermann, O. Mayans
Journal of Molecular Biology - 2021-01-01 -
The N2A region of titin has a unique structural
configuration
C. Stronczek, Stephan Lange, B. Bullard, S. Wolniak, Emma Börgeson, O. Mayans, J. R. Fleming
Journal of General Physiology - 2021-01-01 -
Exploring Obscurin and SPEG Kinase
Biology
J. R. Fleming, Alankrita Rani, Jamie D. Kraft, S. Zenker, Emma Börgeson, Stephan Lange
Journal of Clinical Medicine - 2021-01-01 -
Challenges in PhD education due to COVID-19-disrupted supervision or business as usual: a cross-sectional survey of Swedish biomedical sciences graduate
students
Emma Börgeson, Matus Sotak, Jamie D. Kraft, Christina Biörserud, Stephan Lange
Bmc Medical Education - 2021-01-01 -
The titin N2B and N2A regions: biomechanical and metabolic signaling hubs in cross-striated
muscles
R. J. van der Pijl, A. A. Domenighetti, F. Sheikh, E. Ehler, C. A. C. Ottenheijm, Stephan Lange
Biophysical Reviews - 2021-01-01 -
Desmosomal COP9 regulates proteome degradation in arrhythmogenic right ventricular
dysplasia/cardiomyopathy
Y. Liang, R. C. Lyon, J. Pellman, W. H. Bradford, Stephan Lange, J. Bogomolovas, N. D. Dalton, Y. S. Gu, M. Bobar, M. H. Lee, T. Iwakuma, V. Nigam, A. Asimaki, M. Scheinman, K. L. Peterson, F. Sheikh
Journal of Clinical Investigation - 2021-01-01 -
The Role of Cullin-RING Ligases in Striated Muscle Development, Function, and
Disease
J. Blondelle, A. Biju, Stephan Lange
International Journal of Molecular Sciences - 2020-01-01 -
Brain region-specific amyloid plaque-associated myelin lipid loss, APOE deposition and disruption of the myelin sheath in familial Alzheimer's disease
mice
Ibrahim Kaya, Eva Jennische, Stephan Lange, A. T. Baykal, P. Malmberg, John S. Fletcher
Journal of Neurochemistry - 2020-01-01 -
The M-band: The underestimated part of the
sarcomere
Stephan Lange, N. Pinotsis, I. Agarkova, E. Ehler
Biochimica et Biophysica Acta - Molecular Cell Research - 2020-01-01 -
Comparative analysis of obesity-related cardiometabolic and renal biomarkers in human plasma and
serum.
Meenu Rohin Rajan, Matus Sotak, Fredrik Barrenäs, Tong Shen, Kamil Borkowski, Nicholas J. Ashton, Christina Biörserud, Tomas L Lindahl, Sofia Ramström, Michael Schöll, Per Lindahl, Oliver Fiehn, John W Newman, Rosie Perkins, Ville Wallenius, Stephan Lange, Emma Börgeson
Scientific reports - 2019-01-01 -
miR-486 is modulated by stretch and increases ventricular
growth
Stephan Lange, I. Banerjee, K. Carrion, R. Serrano, L. Habich, R. Kameny, L. Lengenfelder, N. Dalton, R. Meili, Emma Börgeson, K. Peterson, M. Ricci, J. Lincoln, M. Ghassemian, J. Fineman, J. C. del Alamo, V. Nigam
Jci Insight - 2019-01-01 -
Murine obscurin and Obsl1 have functionally redundant roles in sarcolemmal integrity, sarcoplasmic reticulum organization, and muscle
metabolism
J. Blondelle, V. Marrocco, M. Clark, P. Desmond, S. Myers, J. Nguyen, M. Wright, S. Bremner, E. Pierantozzi, S. Ward, E. Esteve, V. Sorrentino, M. Ghassemian, Stephan Lange
Communications Biology - 2019-01-01 -
PKC and PKN in heart
disease
V. Marrocco, J. Bogomolovas, E. Ehler, C. G. dos Remedios, J. Y. Yu, C. Gao, Stephan Lange
Journal of Molecular and Cellular Cardiology - 2019-01-01 -
Cullin-3-dependent deregulation of ACTN1 represents a pathogenic mechanism in nemaline
myopathy
Jordan Blondelle, Kavya Tallapaka, Jane T. Seto, Majid Ghassemian, Madison Clark, Jenni M. Laitila, Adam Bournazos, Jeffrey D. Singer, Stephan Lange
JCI Insight - 2019-01-01