Grupp Yan Chen
Forskningsgrupp
Kort beskrivning
Forskning om onkogen signalering och terapeutisk intervention i solid cancer.
Sammanfattning av forskning
Se engelsk version av sidan.
Forskningsverktyg och resurser
Vi använder primär- och tumörcellinjer, 3D/organoider samt xenografter och genmodiefierade musmodeller för cancerbiologiska studier. En rad cell- och molekylärbiologiska tekniker används.
Gruppmedlemmar
Yan Chen, MD, PhD
Xia Wu, PhD
Utvalda publikationer
- Ganapathy G, Liu J, Xiong R, Yu T, Makriyannis A, Chen YC 2019 Chronic low dose arsenic exposure preferentically perturbs mitotic phase of the cell cycle. Genes & Cancer in press.
- Yu T, Ganapathy S, Shen L, Peng B, Kim SH, Makriyannis A, Chen YC 2018 Phellinus linteus extract is in synergy with camptothecin11 for inducing S phase crisis in colon cancer cells. Oncotarget 9: 6308.
- Ganapathy S, Li P, Lafontant J, Xiong R, Yu T, Zhang G, Chen YC 2017 Chromium IV expresure, via Src/Ras signaling, promotes tumorigenesis in human lung and skin cells. Toxicol Appl Pharm. 56: 1808.
- Choi B, Chen X, Chen YC, Dai W. 2016 WWP2 is required for normal cell cycle progression. Genes & Cancer 6: 371.
- Chen H, Guan R, Lei Y, Chen J, Ge Q, Dou R, Zhang X, Chen H, Qi X, Zhou X, Chen YC. 2015 Lymphangiogenesis in gastric cancer regulated through Akt/mTOR-VEGF-C/VEGF-D axis. BMC Cancer 15: 103.
- Zhou X, Kim SH, Shen L, Lee HJ, Chen YC. 2014 Activation of mitotic catastrophe in NF1 deficient cells by PKC inhibition. Cell Cycle 13: 2340.
- Nishioka T, Luo LY, Shen L, He H, Chen YC. 2014 Nicotine exposure increases the resistance of cancer cells to cisplatin through enhancing Bcl-2 stability. Bri J of Cancer 110: 1785.
- Shen L, Nishioka T, Guo J, Chen YC. 2012 Geminin functions downstream of p53 in v-K-ras-induced DHFR amplification. Cancer Res. 72: 6153.
Kontaktinformation
Chang Yan Chen
E-post: Chang Yan Chen
Telefon: +46 31 786 3870
+46 (0) 729 694915
Besöksadress:
Sahlgrenska Centrum
för Cancerforskning,
Medicinaregatan 1F
413 90 Göteborg