Grupp Yan Chen

Sammanfattning av forskning

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Forskningsverktyg och resurser

Vi använder primär- och tumörcellinjer, 3D/organoider samt xenografter och genmodiefierade musmodeller för cancerbiologiska studier. En rad cell- och molekylärbiologiska tekniker används.

Gruppmedlemmar

Yan Chen, MD, PhD
Xia Wu, PhD

Utvalda publikationer

1. Ganapathy G, Liu J, Xiong R, Yu T, Makriyannis A, Chen YC 2019 Chronic low dose arsenic exposure preferentically perturbs mitotic phase of the cell cycle. Genes & Cancer in press.
    
2. Yu T, Ganapathy S, Shen L, Peng B, Kim SH, Makriyannis A, Chen YC 2018 Phellinus linteus extract is in synergy with camptothecin11 for inducing S phase crisis in colon cancer cells. Oncotarget 9: 6308.
    
3. Ganapathy S, Li P, Lafontant J, Xiong R, Yu T, Zhang G, Chen YC 2017 Chromium IV expresure, via Src/Ras signaling, promotes tumorigenesis in human lung and skin cells. Toxicol Appl Pharm. 56: 1808.
    
4. Choi B, Chen X, Chen YC, Dai W. 2016 WWP2 is required for normal cell cycle progression. Genes & Cancer 6: 371.
    
5. Chen H, Guan R, Lei Y, Chen J, Ge Q, Dou R, Zhang X, Chen H, Qi X, Zhou X, Chen YC. 2015 Lymphangiogenesis in gastric cancer regulated through Akt/mTOR-VEGF-C/VEGF-D axis. BMC Cancer 15: 103.
    
6. Zhou X, Kim SH, Shen L, Lee HJ, Chen YC. 2014 Activation of mitotic catastrophe in NF1 deficient cells by PKC inhibition. Cell Cycle 13: 2340.
    
7. Nishioka T, Luo LY, Shen L, He H, Chen YC. 2014 Nicotine exposure increases the resistance of cancer cells to cisplatin through enhancing Bcl-2 stability. Bri J of Cancer 110: 1785.
    
8. Shen L, Nishioka T, Guo J, Chen YC. 2012 Geminin functions downstream of p53 in v-K-ras-induced DHFR amplification. Cancer Res. 72: 6153.