Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12
| Författare |
J Wiltfang P Lewczuk P Riederer E Grünblatt C Hock P Scheltens H Hampel H Vanderstichele K Iqbal D Galasko L Lannfelt M Otto H Esselmann A W Henkel J Kornhuber Kaj Blennow |
|---|---|
| Publicerad i | The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry |
| Volym | 6 |
| Nummer/häfte | 2 |
| Sidor | 69-84 |
| ISSN | 1562-2975 |
| Publiceringsår | 2005 |
| Publicerad vid |
Institutionen för klinisk neurovetenskap, Sektionen för laborativ neurovetenskap |
| Sidor | 69-84 |
| Språk | en |
| Länkar |
www.ncbi.nlm.nih.gov/entrez/query.f... |
| Ämnesord | Aged, Alzheimer Disease, blood, cerebrospinal fluid, genetics, Amyloid beta-Protein Precursor, cerebrospinal fluid, Apolipoproteins E, genetics, Biological Markers, blood, cerebrospinal fluid, Consensus, Diagnosis, Differential, Genotype, Humans, Immunoblotting, Microtubule-Associated Proteins, metabolism, Neurons, metabolism, Phosphorylation, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Time Factors, tau Proteins, cerebrospinal fluid |
| Ämneskategorier | Medicin och Hälsovetenskap |
Aging of population, and increasing life expectancy result in an increasing number of patients with dementia. This symptom can be a part of a completely curable disease of the central nervous system (e.g, neuroinflammation), or a disease currently considered irreversible (e.g, Alzheimer's disease, AD). In the latter case, several potentially successful treatment approaches are being tested now, demanding reasonable standards of pre-mortem diagnosis. Cerebrospinal fluid and serum analysis (CSF/serum analysis), whereas routinely performed in neuroinflammatory diseases, still requires standardization to be used as an aid to the clinically based diagnosis of AD. Several AD-related CSF parameters (total tau, phosphorylated forms of tau, Abeta peptides, ApoE genotype, p97, etc.) tested separately or in a combination provide sensitivity and specificity in the range of 85%, the figure commonly expected from a good diagnostic tool. In this review, recently published reports regarding progress in neurochemical pre-mortem diagnosis of dementias are discussed with a focus on an early and differential diagnosis of AD. Novel perspectives offered by recently introduced technologies, e.g, fluorescence correlation spectroscopy (FCS) and surface enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) are briefly discussed.
GÖTEBORGS UNIVERSITET • Box 100 • 405 30 Göteborg • Telefon: 031 786 0000
Kontakt • Organisationsnummer: 202100-3153 • Om webbplatsen
Facebook
Twitter
Instagram
Youtube