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The pilot European Alzheimer's Disease Neuroimaging Initiative of the European Alzheimer's Disease Consortium.

Artikel i vetenskaplig tidskrift
Författare Giovanni B Frisoni
Wouter J P Henneman
Michael W Weiner
Philip Scheltens
Bruno Vellas
Emma Reynish
Jaroslava Hudecova
Harald Hampel
Katharina Burger
Kaj Blennow
Gunhild Waldemar
Peter Johannsen
Lars-Olof Wahlund
Giancarlo Zito
Paolo M Rossini
Bengt Winblad
Frederik Barkhof
Publicerad i Alzheimer's & dementia : the journal of the Alzheimer's Association
Volym 4
Nummer/häfte 4
Sidor 255-64
ISSN 1552-5279
Publiceringsår 2008
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
Sidor 255-64
Språk en
Länkar dx.doi.org/10.1016/j.jalz.2008.04.0...
Ämnesord Aged, Aged, 80 and over, Alzheimer Disease, cerebrospinal fluid, pathology, physiopathology, Brain, pathology, physiopathology, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Pilot Projects
Ämneskategorier Medicin och Hälsovetenskap

Sammanfattning

BACKGROUND: In North America, the Alzheimer's Disease Neuroimaging Initiative (ADNI) has established a platform to track the brain changes of Alzheimer's disease. A pilot study has been carried out in Europe to test the feasibility of the adoption of the ADNI platform (pilot E-ADNI). METHODS: Seven academic sites of the European Alzheimer's Disease Consortium (EADC) enrolled 19 patients with mild cognitive impairment (MCI), 22 with AD, and 18 older healthy persons by using the ADNI clinical and neuropsychological battery. ADNI compliant magnetic resonance imaging (MRI) scans, cerebrospinal fluid, and blood samples were shipped to central repositories. Medial temporal atrophy (MTA) and white matter hyperintensities (WMH) were assessed by a single rater by using visual rating scales. RESULTS: Recruitment rate was 3.5 subjects per month per site. The cognitive, behavioral, and neuropsychological features of the European subjects were very similar to their U.S. counterparts. Three-dimensional T1-weighted MRI sequences were successfully performed on all subjects, and cerebrospinal fluid samples were obtained from 77%, 68%, and 83% of AD patients, MCI patients, and controls, respectively. Mean MTA score showed a significant increase from controls (left, right: 0.4, 0.3) to MCI patients (0.9, 0.8) to AD patients (2.3, 2.0), whereas mean WMH score did not differ among the three diagnostic groups (between 0.7 and 0.9). The distribution of both MRI markers was comparable to matched US-ADNI subjects. CONCLUSIONS: Academic EADC centers can adopt the ADNI platform to enroll MCI and AD patients and older controls with global cognitive and structural imaging features remarkably similar to those of the US-ADNI.

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