Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

The effects of normal agi… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

The effects of normal aging and ApoE genotype on the levels of CSF biomarkers for Alzheimer's disease.

Artikel i vetenskaplig tidskrift
Författare Lidia Glodzik-Sobanska
Elizabeth Pirraglia
Miroslaw Brys
Susan De Santi
Lisa Mosconi
Kenneth E Rich
Remigiusz Switalski
Leslie Saint Louis
Martin J Sadowski
Frank Martiniuk
Pankaj Mehta
Domenico Pratico
Raymond P Zinkowski
Kaj Blennow
Mony J de Leon
Publicerad i Neurobiology of aging
Volym 30
Nummer/häfte 5
Sidor 672-81
ISSN 1558-1497
Publiceringsår 2009
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
Sidor 672-81
Språk en
Länkar dx.doi.org/10.1016/j.neurobiolaging...
Ämnesord Adult, Aged, Aged, 80 and over, Aging, genetics, metabolism, Alzheimer Disease, cerebrospinal fluid, diagnosis, genetics, Amyloid beta-Protein, analysis, cerebrospinal fluid, Apolipoprotein E4, genetics, Apolipoproteins E, genetics, Biological Markers, analysis, cerebrospinal fluid, DNA Mutational Analysis, Dinoprost, analogs & derivatives, analysis, cerebrospinal fluid, Female, Gene Frequency, genetics, Genetic Predisposition to Disease, genetics, Genotype, Humans, Male, Middle Aged, Oxidative Stress, genetics, Peptide Fragments, analysis, cerebrospinal fluid, Phosphorylation, Polymorphism, Genetic, genetics, tau Proteins, analysis, cerebrospinal fluid
Ämneskategorier Medicin och Hälsovetenskap

Sammanfattning

While cerebrospinal fluid (CSF) biomarkers are of use in the prediction and diagnosis of Alzheimer's disease our understanding of the background effects of age and the ApoE genotype is limited. Seventy-eight community-based normal volunteers (mean age 60+/-10 years, range 36-86) were examined to determine the relationships between CSF measures of total tau (T-tau), hyperphosphorylated tau (P-tau 231), amyloid beta (Abeta42/Abeta40 ratio), and isoprostane (IP) with age and ApoE genotype. The results showed that age by epsilon4 genotype interactions were found for P-tau231 (beta=1.82; p<0.05) and IP (beta=1.6; p<0.05). T-tau CSF concentration increased with age. The increasing CSF concentrations of P-tau and IP in epsilon4 carriers suggest that early tauopathy and oxidative stress may be related to the increased risk for AD. The data also suggest that T-tau changes are more age dependent than Abeta changes. The evidence that P-tau231 and IP are the earliest markers for the neuronal damage related to AD awaits longitudinal study.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?