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Subgroups of Alzheimer's disease based on cerebrospinal fluid molecular markers.

Artikel i vetenskaplig tidskrift
Författare Khalid Iqbal
Michael Flory
Sabiha Khatoon
Hilkka Soininen
Tuula Pirttila
Maarit Lehtovirta
Irina Alafuzoff
Kaj Blennow
Niels Andreasen
Eugeen Vanmechelen
Inge Grundke-Iqbal
Publicerad i Annals of neurology
Volym 58
Nummer/häfte 5
Sidor 748-57
ISSN 0364-5134
Publiceringsår 2005
Publicerad vid Institutionen för klinisk neurovetenskap, Sektionen för laborativ neurovetenskap
Sidor 748-57
Språk en
Länkar dx.doi.org/10.1002/ana.20639
Ämnesord Aged, Aged, 80 and over, Alzheimer Disease, cerebrospinal fluid, Amyloid beta-Protein, cerebrospinal fluid, Apolipoprotein E4, Apolipoproteins E, genetics, Blotting, Western, methods, Cluster Analysis, Enzyme-Linked Immunosorbent Assay, methods, Female, Humans, Male, Middle Aged, Models, Statistical, Neurofibrillary Tangles, pathology, Peptide Fragments, cerebrospinal fluid, Postmortem Changes, Senile Plaques, pathology, Ubiquitin, cerebrospinal fluid, tau Proteins, cerebrospinal fluid
Ämneskategorier Psykiatri

Sammanfattning

Alzheimer's disease, the most common cause of dementia, is multifactorial and heterogeneous; its diagnosis remains probable. We postulated that more than one disease mechanism yielded Alzheimer's histopathology, and that subgroups of the disease might be identified by the cerebrospinal fluid (CSF) levels of proteins associated with senile (neuritic) plaques and neurofibrillary tangles. We immunoassayed levels of tau, ubiquitin, and Abeta(1-42) in retrospectively collected CSF samples of 468 clinically diagnosed Alzheimer's disease patients (N = 353) or non-Alzheimer's subjects (N = 115). Latent profile analysis assigned each subject to a cluster based on the levels of these molecular markers. Alzheimer's disease was subdivided into at least five subgroups based on CSF levels of Abeta(1-42), tau, and ubiquitin; each subgroup presented a different clinical profile. These subgroups, which can be identified by CSF analysis, might benefit differently from different therapeutic drugs.

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