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Elevated plasma levels of soluble CD40 in incipient Alzheimer's disease.

Artikel i vetenskaplig tidskrift
Författare Peder Buchhave
Sabina Janciauskiene
Henrik Zetterberg
Kaj Blennow
Lennart Minthon
Oskar Hansson
Publicerad i Neuroscience letters
Volym 450
Nummer/häfte 1
Sidor 56-9
ISSN 0304-3940
Publiceringsår 2009
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
Sidor 56-9
Språk en
Länkar dx.doi.org/10.1016/j.neulet.2008.10...
Ämnesord Age Factors, Aged, Alzheimer Disease, blood, physiopathology, Antigens, CD40, blood, CD40 Ligand, blood, Cognition Disorders, blood, physiopathology, Enzyme-Linked Immunosorbent Assay, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neuropsychological Tests, Sex Factors, Solubility, Statistics, Nonparametric
Ämneskategorier Psykiatri

Sammanfattning

CD40 is a member of the tumor necrosis factor receptor super-family and has been suggested to play a role in the metabolism of beta-amyloid (Abeta) in Alzheimer's disease (AD). However, the role of CD40-signalling in incipient AD has not yet been studied. We investigated the plasma levels of soluble CD40 (sCD40) and the soluble CD40 ligand (sCD40L) at baseline in 136 subjects with mild cognitive impairment (MCI) and 30 age-matched controls. Sixty of the 136 MCI cases converted to AD (MCI-AD) during a clinical follow-up period of 4-7 years. The baseline levels of sCD40, but not sCD40L, were elevated in MCI-AD cases when compared to age-matched controls (Mann-Whitney U-test, p=0.02). However, MCI patients who were cognitively stable or developed vascular dementia during follow-up did not have significantly increased levels of sCD40 or sCD40L when compared to controls. The levels of sCD40 correlated to decreased baseline performance on mini-mental state examination (MMSE) in both controls (r(s)=-0.37, p<0.05) and MCI-AD cases (r(s)=-0.29, p<0.05). Finally, the plasma levels of sCD40 correlated with the levels of soluble amyloid precursor protein-alpha (sAPP-alpha) (r(s)=0.28, p<0.01) and sAPP-beta (r(s)=0.23, p<0.05) in cerebrospinal fluid. In conclusion, CD40-signalling might play a role in the pathogenesis of early AD.

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