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Monitoring of brain interstitial total tau and beta amyloid proteins by microdialysis in patients with traumatic brain injury.

Artikel i vetenskaplig tidskrift
Författare Niklas Marklund
Kaj Blennow
Henrik Zetterberg
Elisabeth Ronne-Engström
Per Enblad
Lars Hillered
Publicerad i Journal of neurosurgery
Volym 110
Nummer/häfte 6
Sidor 1227-37
ISSN 0022-3085
Publiceringsår 2009
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
Sidor 1227-37
Språk en
Länkar dx.doi.org/10.3171/2008.9.JNS08584
Ämnesord Adolescent, Adult, Aged, Amyloid beta-Protein, metabolism, Biological Markers, metabolism, Cohort Studies, Diffuse Axonal Injury, diagnosis, etiology, metabolism, Female, Humans, Male, Microdialysis, Middle Aged, Peptide Fragments, metabolism, Pilot Projects, Predictive Value of Tests, Risk Factors, Young Adult, tau Proteins, metabolism
Ämneskategorier Psykiatri

Sammanfattning

OBJECT: Damage to axons contributes to postinjury disabilities and is commonly observed following traumatic brain injury (TBI). Traumatic brain injury is an important environmental risk factor for the development of Alzheimer disease (AD). In the present feasibility study, the aim was to use intracerebral microdialysis catheters with a high molecular cutoff membrane (100 kD) to harvest interstitial total tau (T-tau) and amyloid beta 1-42 (Abeta42) proteins, which are important biomarkers for axonal injury and for AD, following moderate-to-severe TBI.METHODS: Eight patients (5 men and 3 women) were included in the study; 5 of the patients had a focal/mixed TBI and 3 had a diffuse axonal injury (DAI). Following the bedside analysis of the routinely measured energy metabolic markers (that is, glucose, lactate/pyruvate ratio, glycerol, and glutamate), the remaining dialysate was pooled and two 12-hour samples per day were used to analyze T-tau and Abeta42 by enzyme-linked immunosorbent assay from Day 1 up to 8 days postinjury.RESULTS: The results show high levels of interstitial T-tau and Abeta42 postinjury. Patients with a predominantly focal lesion had higher interstitial T-tau levels than in the DAI group from Days 1 to 3 postinjury (p < 0.05). In contrast, patients with DAI had consistently higher Abeta42 levels when compared with patients with focal injury.CONCLUSIONS: These results suggest that monitoring of interstitial T-tau and Abeta42 by using microdialysis may be an important tool when evaluating the presence and role of axonal injury following TBI.

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