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Somatotopic organization of gentle touch processing in the posterior insular cortex.

Artikel i vetenskaplig tidskrift
Författare Malin Björnsdotter
Line Sofie Löken
Håkan Olausson
Åke Vallbo
Johan Wessberg
Publicerad i The Journal of neuroscience : the official journal of the Society for Neuroscience
Volym 29
Nummer/häfte 29
Sidor 9314-20
ISSN 1529-2401
Publiceringsår 2009
Publicerad vid Institutionen för neurovetenskap och fysiologi
Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering
Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi
Sidor 9314-20
Språk en
Länkar dx.doi.org/10.1523/JNEUROSCI.0400-0...
Ämnesord Adult, Afferent Pathways, physiology, Brain, physiology, Brain Mapping, Cluster Analysis, Female, Forearm, innervation, physiology, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Fibers, Unmyelinated, physiology, Parietal Lobe, physiology, Physical Stimulation, Temporal Lobe, physiology, Thigh, innervation, physiology, Touch, physiology, Touch Perception, physiology, Young Adult
Ämneskategorier Experimentell hjärnforskning, Neurofysiologi

Sammanfattning

A network of thin (C and A delta) afferents relays various signals related to the physiological condition of the body, including sensations of gentle touch, pain, and temperature changes. Such afferents project to the insular cortex, where a somatotopic organization of responses to noxious and cooling stimuli was recently observed. To explore the possibility of a corresponding body-map topography in relation to gentle touch mediated through C tactile (CT) fibers, we applied soft brush stimuli to the right forearm and thigh of a patient (GL) lacking A beta afferents, and six healthy subjects during functional magnetic resonance imaging (fMRI). For improved fMRI analysis, we used a highly sensitive multivariate voxel clustering approach. A somatotopic organization of the left (contralateral) posterior insular cortex was consistently demonstrated in all subjects, including GL, with forearm projecting anterior to thigh stimulation. Also, despite denying any sense of touch in daily life, GL correctly localized 97% of the stimuli to the forearm or thigh in a forced-choice paradigm. The consistency in activation patterns across GL and the healthy subjects suggests that the identified organization reflects the central projection of CT fibers. Moreover, substantial similarities of the presently observed insular activation with that described for noxious and cooling stimuli solidify the hypothesized sensory-affective role of the CT system in the maintenance of physical well-being as part of a thin-afferent homeostatic network.

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