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Sympathetic and cardiovascular activity during cataplexy in narcolepsy.

Artikel i vetenskaplig tidskrift
Författare Vincenzo Donadio
Giuseppe Plazzi
Stefano Vandi
Christian Franceschini
Tomas Karlsson
Pasquale Montagna
Roberto Vetrugno
Enrico Bugiardini
Emmanuel Mignot
Rocco Liguori
Publicerad i Journal of sleep research
Volym 17
Nummer/häfte 4
Sidor 458-63
ISSN 1365-2869
Publiceringsår 2008
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering
Sidor 458-63
Språk en
Länkar dx.doi.org/10.1111/j.1365-2869.2008...
Ämnesord Blood Pressure, physiology, Cataplexy, physiopathology, Electrocardiography, Electroencephalography, Electromyography, Electrooculography, Heart Rate, physiology, Humans, Intracellular Signaling Peptides and Proteins, deficiency, Male, Narcolepsy, metabolism, physiopathology, Neuropeptides, deficiency, Sympathetic Nervous System, physiopathology, Young Adult
Ämneskategorier Medicin och Hälsovetenskap

Sammanfattning

Autonomic nervous system activity changes have been described during cataplexy as playing a role in triggering it. To confirm these previous findings, we investigated the time course of sympathetic and cardiovascular activities during cataplexy. We made for the first time microneurographic recordings of 10 cataplectic episodes in three patients with hypocretin-deficient narcolepsy. During microneurography, muscle sympathetic nerve activity (MSNA) was recorded simultaneously with heart rate (HR), respiratory movements, arterial finger blood pressure (BP), electroencephalography, electro-oculogram and superficial electromyogram. Results showed no significant autonomic changes before the onset of the cataplectic episodes. Cataplexy was associated with a significant increase in MSNA and BP compared with baseline, whereas HR was markedly decreased. An irregular breathing pattern mainly characterized by apnea typically occurred during the attacks. In conclusion, our findings did not show significant changes in autonomic activity prior to cataplexy onset, ruling out a triggering role of the autonomic system. However, cataplexy was associated with co-activation of sympathetic and parasympathetic autonomic systems, a pattern reminiscent of that reported during the vigilance reaction in animals.

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