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Regional cerebral blood flow in normal individuals aged 40, 75 and 88 years studied by 99Tc(m)-d,l-HMPAO SPET.

Artikel i vetenskaplig tidskrift
Författare A Larsson
Ingmar Skoog
O Aevarsson
A Arlig
L Jacobsson
L Larsson
Svante Östling
Carsten Wikkelsö
Publicerad i Nuclear medicine communications
Volym 22
Nummer/häfte 7
Sidor 741-6
ISSN 0143-3636
Publiceringsår 2001
Publicerad vid Institutionen för klinisk neurovetenskap
Institutionen för klinisk neurovetenskap, Sektionen för psykiatri
Sidor 741-6
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Adult, Aged, Aged, 80 and over, Aging, physiology, Brain, radionuclide imaging, Cerebrovascular Circulation, physiology, Female, Humans, Male, Radiopharmaceuticals, diagnostic use, Reference Values, Technetium Tc 99m Exametazime, diagnostic use, Tomography, Emission-Computed, Single-Photon
Ämneskategorier Neurologi

Sammanfattning

Age-related changes in cerebral blood flow (CBF) were examined with [99Tc(m)]-d,l-hexamethylpropylene amine oxime (HMPAO), using a single photon emission tomography (SPET) gamma camera system equipped with a high resolution collimator, in 33 normal individuals in three age groups: 40 years old (n = 11), 75 years old (n = 9) and 88 years old (n = 13). A standard activity of 1000 MBq [99Tc(m)]-d,l-HMPAO was administered. Regional CBF (rCBF) (relative to cerebellar counts) was quantified in 28 grey and white matter regions. The mean rCBF of all the regions was 0.80 (95% confidence interval [CI] 0.77-0.83) in 40 year olds, 0.77 (0.74-0.80) in 75 year olds and 0.76 (0.73-0.78) in 88 year olds. rCBF in the hippocampus, angular and cingular gyri, and frontal association and motor cortices was 5-10% lower in the 75 and 88 year olds than in the middle-aged subjects (P < 0.05). The annual reduction in rCBF was 0.10% between the ages of 40 and 75 years and 0.13% between the ages of 75 and 88 years. The reduction in rCBF in the hippocampus rose from 0.14% between the ages of 40 and 75 years to 0.33% between the ages of 75 and 88 years. The mean rCBF in all 33 individuals showed no sex-related differences.

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