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Serotonin transporter gene polymorphisms are associated with anxiety-related personality traits in women.

Artikel i vetenskaplig tidskrift
Författare Jonas Melke
Mikael Landén
Fariba Baghaei
Roland Rosmond
Göran Holm
Per Björntorp
Lars Westberg
Monika Hellstrand
Elias Eriksson
Publicerad i American journal of medical genetics
Volym 105
Nummer/häfte 5
Sidor 458-63
ISSN 0148-7299
Publiceringsår 2001
Publicerad vid Institutionen för fysiologi och farmakologi, Avdelningen för farmakologi
Institutionen för klinisk neurovetenskap, Sektionen för psykiatri
Institutionen för invärtesmedicin, Avdelningen för lungmedicin och allergologi
Sidor 458-63
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Alleles, Anxiety, genetics, psychology, Anxiety Disorders, genetics, psychology, Carrier Proteins, genetics, Cohort Studies, DNA, genetics, Female, Gene Frequency, Genotype, Humans, Membrane Glycoproteins, genetics, Membrane Transport Proteins, Middle Aged, Nerve Tissue Proteins, Personality Assessment, Phenotype, Polymorphism, Genetic, Psychiatric Status Rating Scales, Serotonin Plasma Membrane Transport Proteins
Ämneskategorier Farmakologi och toxikologi

Sammanfattning

Several studies have reported an association between anxiety-related personality traits and a promoter polymorphism in the human serotonin transporter (5-HTT) gene (5-HTT gene-linked polymorphic region, 5-HTTLPR). In the present study, a population of 251 subjects was assessed with the Karolinska Scales of Personality (KSP) and genotyped both for the 5-HTTLPR and for a variable number of tandem repeats polymorphism in the second intron of the same gene. The interpretation of previous studies has to some extent been confounded by the studied subjects differing with respect to ethnicity, sex, and age. To circumvent this problem, all included subjects were Caucasians, women, and born in the same year (1956). Associations were found between the 5-HTTLPR and four of the five anxiety-related KSP scales (psychic anxiety, muscular tension, psychasthenia, and lack of assertiveness), subjects being homozygous for the short allele displaying higher anxiety scores than those of the long/long or long/short genotype. In addition, an association was found between the intron 2 polymorphism and one anxiety-related personality trait (somatic anxiety).

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