Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

The serotonin reuptake in… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

The serotonin reuptake inhibitor fluoxetine reduces sex steroid-related aggression in female rats: an animal model of premenstrual irritability?

Artikel i vetenskaplig tidskrift
Författare Hoi-Por Ho
Marie Olsson
Lars Westberg
Jonas Melke
Elias Eriksson
Publicerad i Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Volym 24
Nummer/häfte 5
Sidor 502-10
ISSN 0893-133X
Publiceringsår 2001
Publicerad vid Institutionen för fysiologi och farmakologi, Avdelningen för farmakologi
Sidor 502-10
Språk en
Länkar dx.doi.org/10.1016/S0893-133X(00)00...
Ämnesord Aggression, drug effects, physiology, Animals, Behavior, Animal, drug effects, physiology, Brain, drug effects, metabolism, physiopathology, Disease Models, Animal, Estradiol, pharmacology, Estrus, drug effects, physiology, Female, Fluoxetine, pharmacology, Ovariectomy, Premenstrual Syndrome, drug therapy, metabolism, physiopathology, Progesterone, pharmacology, Rats, Rats, Wistar, Serotonin, metabolism, Serotonin Uptake Inhibitors, pharmacology
Ämneskategorier Farmakologi och toxikologi

Sammanfattning

The aggressive behavior displayed by some (but not all) female Wistar rats when an unfamiliar rat is being introduced into their home cage (the resident intruder paradigm) was found to be higher in non-receptive phases (metestrus, diestrus) than in the receptive phases (proestrus, estrus) of the estrus cycle, and effectively reduced by ovariectomy. When removal of the ovaries was followed by administration of estradiol and progesterone, in a regimen mimicking the normal cyclical release of these hormones, aggressive behavior was elicited, two days after estrus, in animals that had displayed aggressive behavior before ovariectomy, but not in those that had not. Short-term administration of a serotonin reuptake inhibitor (fluoxetine hydrochloride; 10 mg/kg, i.p.; 4-5 days) reduced both the aggressive behavior displayed during the diestrus phase by normally cycling rats, and the aggressive behavior elicited by administration of estradiol plus progesterone after ovariectomy. It is suggested that the aggressive behavior displayed by the female Wistar rat in the resident intruder paradigm may serve as an animal model of premenstrual dysphoria.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?