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Premotor interneurones contributing to actions of feline pyramidal tract neurones on ipsilateral hindlimb motoneurones.

Artikel i vetenskaplig tidskrift
Författare Katinka Stecina
Elzbieta Jankowska
Anna Cabaj
Lars-Gunnar Pettersson
B A Bannatyne
D J Maxwell
Publicerad i The Journal of physiology
Volym 586
Nummer/häfte 2
Sidor 557-74
ISSN 0022-3751
Publiceringsår 2008
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi
Sidor 557-74
Språk en
Länkar dx.doi.org/10.1113/jphysiol.2007.14...
https://gup.ub.gu.se/file/141007
Ämnesord Animals, Cats, Electric Stimulation, Excitatory Postsynaptic Potentials, physiology, Hindlimb, innervation, Inhibitory Postsynaptic Potentials, physiology, Interneurons, physiology, Motor Neurons, physiology, Neural Conduction, physiology, Pyramidal Tracts, physiology, Synapses, physiology
Ämneskategorier Fysiologi, Neurofysiologi

Sammanfattning

The aim of the study was to analyse the potential contribution of excitatory and inhibitory premotor interneurones in reflex pathways from muscle afferents to actions of pyramidal tract (PT) neurones on ipsilateral hindlimb motoneurones. Disynaptic EPSPs and IPSPs evoked in motoneurones in deeply anaesthetized cats by group Ia, Ib and II muscle afferents were found to be facilitated by stimulation of the ipsilateral, as well as of contralateral, PT. The ipsilateral actions were evoked by either uncrossed or double-crossed pathways. The results show that interneurones mediating reflex actions of muscle afferents may be activated strongly enough by PT stimulation to contribute to movements initiated by ipsilateral PT neurones and that PT actions relayed by them might be enhanced by muscle stretches and/or contractions. However, in some motoneurones disynaptic IPSPs and EPSPs evoked from group Ib or II afferents were depressed by PT stimulation. In order to analyse the basis of this depression, the transmitter content in terminals of 11 intracellularly labelled interneurones excited by PT stimulation was defined immunohistochemically and their axonal projections were reconstructed. The interneurones included 9 glycinergic and 2 glutamatergic neurones. All but one of these neurones were mono- or disynaptically excited by group I and/or II afferents. Several projected to motor nuclei and formed contacts with motoneurones. However, all had terminal projections to areas outside the motor nuclei. Therefore both inhibitory and excitatory interneurones could modulate responses of other premotor interneurones in parallel with direct actions on motoneurones.

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