Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12
| Författare |
Rolf Anckarsäter N Vasic L Jidéus M Kristiansson Henrik Zetterberg Kaj Blennow Henrik Anckarsäter |
|---|---|
| Publicerad i | Acta neurologica Scandinavica |
| Volym | 115 |
| Nummer/häfte | 4 |
| Sidor | 254-9 |
| ISSN | 0001-6314 |
| Publiceringsår | 2007 |
| Publicerad vid |
Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi |
| Sidor | 254-9 |
| Språk | en |
| Länkar |
dx.doi.org/10.1111/j.1600-0404.2006... |
| Ämnesord | Aged, Aged, 80 and over, Arthroplasty, Replacement, Knee, adverse effects, Cerebrospinal Fluid Proteins, metabolism, Female, Humans, Intramolecular Oxidoreductases, blood, cerebrospinal fluid, Intraoperative Period, Lipocalins, Male, Middle Aged, Postoperative Period, Serum Albumin, metabolism, Stress, Physiological, blood, cerebrospinal fluid, etiology, beta 2-Microglobulin, blood, cerebrospinal fluid |
| Ämneskategorier | Medicin och Hälsovetenskap |
OBJECTIVE: To study changes in cerebrospinal fluid (CSF) protein markers of blood-CSF barrier integrity and immunological reactions during surgical stress. SUBJECTS AND METHODS: Thirty-five patients without neurological or psychiatric disorders undergoing knee replacements had CSF and serum samples drawn from spinal and arterial catheters before, 3 h after and the morning after surgery. RESULTS: Serum albumin decreased during surgery and CSF albumin decreased during and after surgery, and, as a consequence, the CSF/serum albumin ratio decreased significantly during the study period, especially after the intervention. In contrast, CSF concentrations of beta-2-microglobuline (beta2M) increased significantly during surgery and remained high. The CSF general marker beta-trace protein (betaTP) remained unchanged. CONCLUSIONS: Central nervous system protein reactions to a non-neurological surgical intervention include sharply decreased permeability of albumin into the CSF and signs of intrathecal inflammatory activity.
GÖTEBORGS UNIVERSITET • Box 100 • 405 30 Göteborg • Telefon: 031 786 0000
Kontakt • Organisationsnummer: 202100-3153 • Om webbplatsen
Facebook
Twitter
Instagram
Youtube