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Gender-specific proteomic responses in zebrafish liver following exposure to a selected mixture of brominated flame retardants

Artikel i vetenskaplig tidskrift
Författare Peter Kling
A Norman
P.L. Andersson
L Norrgren
Lars Förlin
Publicerad i Ecotoxicology and Environmental Safety
Volym 71
Nummer/häfte 2
Sidor 319-327
ISSN 0147-6513
Publiceringsår 2008
Publicerad vid Zoologiska institutionen, zoofysiologi
Sidor 319-327
Språk en
Länkar dx.doi.org/10.1016/j.ecoenv.2007.12...
Ämnesord Fish; Proteomics; BFR; MALDI-TOF
Ämneskategorier Zoofysiologi

Sammanfattning

Proteomic effect screening in zebrafish liver was performed to generate hypotheses following exposure (21 days) to a structurally diverse mixture of brominated flame retardants (BFRs). Fish were exposed to two doses (10 and 100 nmol/g feed). Two-dimensional gel-electrophoresis, image analysis and MALDI-TOF mass-spectrometry revealed 13 and 19 significant responses in males and females, respectively. Effects on proteins related to cellular maintenance and stress were observed in both genders. Regulated proteins were gender-specific, but functionally indicated common protective responses (peroxiredoxin 6 and Zgc:92891 in males and transketolase in females) suggesting oxidative stress. Betaine homocysteine methyltransferase (BHMT) was induced in both genders. In addition a female-specific downregulation of ironhomeostatic proteins (iron-regulatory protein 1 and transferrin) were observed. Our proteomic approach revealed novel responses that suggest important gender-specific sensitiviy to BFRs that should be considered when interpreting adverse effects of BFRs.

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