Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Five mucosal transcripts … - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Five mucosal transcripts of interest in ulcerative colitis identified by quantitative real-time PCR: a prospective study.

Artikel i vetenskaplig tidskrift
Författare Anders Eriksson
Carl-Fredrik Flach
Anders Lindgren
Eva Kvifors
Stefan Lange
Publicerad i BMC gastroenterology
Volym 8
Sidor 34
ISSN 1471-230X
Publiceringsår 2008
Publicerad vid Institutionen för biomedicin
Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi
Institutionen för medicin, avdelningen för akut och kardiovaskulär medicin
Institutionen för biomedicin, avdelningen för infektionssjukdomar
Sidor 34
Språk en
Länkar dx.doi.org/10.1186/1471-230X-8-34
Ämnesord Adult, Aged, Aged, 80 and over, Amino Acid Transport Systems, Neutral, genetics, metabolism, Biopsy, Carrier Proteins, genetics, metabolism, Case-Control Studies, Cecum, metabolism, pathology, Colitis, Ulcerative, metabolism, pathology, Elafin, genetics, metabolism, Female, Fructose-Bisphosphate Aldolase, genetics, metabolism, Hepatocyte Growth Factor, genetics, metabolism, Humans, Male, Middle Aged, Mucous Membrane, metabolism, pathology, Polymerase Chain Reaction, Prospective Studies, Proto-Oncogene Proteins, genetics, metabolism, Rectum, metabolism, pathology, Transcription, Genetic
Ämneskategorier Molekylärbiologi, Molekylärbiologi

Sammanfattning

BACKGROUND: The cause and pathophysiology of ulcerative colitis are both mainly unknown. We have previously used whole-genome microarray technique on biopsies obtained from patients with ulcerative colitis to identify 5 changed mucosal transcripts. The aim of this study was to compare mucosal expressions of these five transcripts in ulcerative colitis patients vs. controls, along with the transcript expression in relation to the clinical ulcerative colitis status. METHODS: Colonic mucosal specimens from rectum and caecum were taken at ambulatory colonoscopy from ulcerative colitis patients (n = 49) with defined inflammatory activity and disease extension, and from controls (n = 67) without inflammatory bowel disease. The five mucosal transcripts aldolase B, elafin, MST-1, simNIPhom and SLC6A14 were analyzed using quantitative real-time PCR. RESULTS: Significant transcript differences in the rectal mucosa for all five transcripts were demonstrated in ulcerative colitis patients compared to controls. The grade of transcript expression was related to the clinical disease activity. CONCLUSION: The five gene transcripts were changed in patients with ulcerative colitis, and were related to the disease activity. The known biological function of some of the transcripts may contribute to the inflammatory features and indicate a possible role of microbes in ulcerative colitis. The findings may also contribute to our pathophysiological understanding of ulcerative colitis.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?