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Episodic memory and speed/attention deficits are associated with Alzheimer-typical CSF abnormalities in MCI

Artikel i vetenskaplig tidskrift
Författare Arto Nordlund
Sindre Rolstad
Ola Klang
Karin Lind
Mona Pedersen
Kaj Blennow
Åke Edman
Stefan Hansen
Anders Wallin
Publicerad i Journal of the International Neuropsychological Society
Volym 14
Nummer/häfte 4
Sidor 582-590
ISSN 1355-6177
Publiceringsår 2008
Publicerad vid Institutionen för neurovetenskap och fysiologi
Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
Psykologiska institutionen
Sidor 582-590
Språk en
Länkar doi: 10.1017/S135561770808079X
Ämnesord mild cognitive impairment, tau,
Ämneskategorier Psykiatri

Sammanfattning

Mild cognitive impairment (MCI) is regarded as the prodromal stage of dementia disorders, such as Alzheimer's disease (AD). Objective: To compare the neuropsychological profiles of MCI subjects with normal concentrations of total tau (T-τ) and Aβ42 in CSF (MCI-norm) to MCI subjects with deviating concentrations of the biomarkers (MCI-dev). MCI-norm (N = 73) and MCI-dev (N = 73) subjects were compared to normal controls (N = 50) on tests of speed/attention, memory, visuospatial function, language and executive function. Results: MCI-norm performed overall better than MCI-dev, specifically on tests of speed and attention and episodic memory. When MCI-dev subjects were subclassified into those with only high T-tau (MCI-tau), only low Aβ42 (MCI-Aβ) and both high T-tau and low Aβ42 (MCI-tauAβ), MCI-tauAβ tended to perform slightly worse. MCI-tau and MCI-Aβ performed quite similarly. Conclusions: Considering the neuropsychological differences, many MCI-norm probably had more benign forms of MCI, or early non-AD forms of neurodegenerative disorders. Although most MCI-dev performed clearly worse than MCI-norm on the neuropsychological battery, some did not show any deficits when compared to age norms. A combination of CSF analyses and neuropsychology could be a step toward a more exact diagnosis of MCI as prodromal AD.

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