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Biomechanical, Histological and Ultrastructural Analyses of Laser Micro- and Nano-structured Titanium Alloy Implants: A Study in Rabbit

Artikel i vetenskaplig tidskrift
Författare Anders Palmquist
F. Lindberg
Lena Emanuelsson
Rickard Brånemark
Håkan Engqvist
Peter Thomsen
Publicerad i Journal of Biomedical Materials Research, Part A
Volym 92A
Nummer/häfte 4
Sidor 1476-1486
ISSN 1552-4965
Publiceringsår 2010
Publicerad vid Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap
Sidor 1476-1486
Språk en
Länkar dx.doi.org/10.1002/jbm.a.32439
Ämnesord Biomaterials, FIB, TEM
Ämneskategorier Biomaterialvetenskap, Klinisk medicin

Sammanfattning

The aim of this study was to evaluate the biomechanical properties and ultrastructure of the bone response of partly laser-modified Ti6Al4V implants compared with turned, machined implants after 8 weeks in rabbit. The surface analyses performed with interference microscopy and electron microscopy showed increased surface topography with micro- and nano-sized surface features as well as increased oxide thickness of the modified surface. The biomechanical testing demonstrated a 270% increase in torque value for the surface modified implants compared with the control implants. Histological evaluation of ground sections of specimens subjected to biomechanical testing revealed ongoing bone formation and remodeling. A histological feature exclusively observed at the laser-modified surface was the presence of fracture in the mineralized bone rather than at the interface between the bone and implant. Transmission electron microscopy (TEM) was performed on Focused Ion Beam (FIB) prepared samples of the intact bone-implant interface, demonstrating a direct contact between nanocrystalline hydroxyapatite and the oxide of the laser-modified implant surface. In conclusion, laser-modified titanium alloy implants have significantly stronger bone anchorage compared with machined implants and show no adverse tissue reactions.

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