Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Mucosal and systemic immu… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Mucosal and systemic immune responses in patients with diarrhea due to CS6-expressing enterotoxigenic Escherichia coli.

Artikel i vetenskaplig tidskrift
Författare Firdausi Qadri
Tanvir Ahmed
Firoz Ahmed
M Saruar Bhuiyan
Mohammad Golam Mostofa
Frederick J Cassels
Anna Helander
Ann-Mari Svennerholm
Publicerad i Infection and immunity
Volym 75
Nummer/häfte 5
Sidor 2269-74
ISSN 0019-9567
Publiceringsår 2007
Publicerad vid Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi
Sidor 2269-74
Språk en
Länkar dx.doi.org/10.1128/IAI.01856-06
Ämnesord Adolescent, Adult, Antibodies, Bacterial, analysis, blood, immunology, Antibody Specificity, Antigens, Bacterial, genetics, immunology, metabolism, Child, Preschool, Diarrhea, immunology, microbiology, Escherichia coli, immunology, pathogenicity, Escherichia coli Infections, immunology, microbiology, Escherichia coli Proteins, genetics, immunology, metabolism, Feces, chemistry, Female, Hospitalization, Humans, Immunity, Mucosal, Immunoglobulin A, Secretory, analysis, blood, immunology, Immunoglobulin G, blood, Infant, Male, Middle Aged, Recombinant Proteins, genetics, immunology, metabolism
Ämneskategorier Mikrobiologi inom det medicinska området

Sammanfattning

Colonization factor CS6 expressed by enterotoxigenic Escherichia coli (ETEC) is a nonfimbrial polymeric protein. A substantial proportion of ETEC strains isolated from patients in endemic settings and in people who travel to regions where ETEC is endemic are ETEC strains expressing CS6, either alone or in combination with fimbrial colonization factor CS5 or CS4. However, relatively little is known about the natural immune responses elicited against CS6 expressed by ETEC strains causing disease. We studied patients who were hospitalized with diarrhea (n = 46) caused by CS6-expressing ETEC (ETEC expressing CS6 or CS5 plus CS6) and had a disease spectrum ranging from severe dehydration (27%) to moderate or mild dehydration (73%). Using recombinant CS6 antigen, we found that more than 90% of the patients had mucosal immune responses to CS6 expressed as immunoglobulin (IgA) antibody-secreting cells (ASC) or antibody in lymphocyte supernatant (ALS) and that about 57% responded with CS6-specific IgA antibodies in feces. More than 80% of the patients showed IgA seroconversion to CS6. Significant increases in the levels of anti-CS6 antibodies of the IgG isotype were also observed in assays for ASC (75%), ALS (100%), and serum (70%). These studies demonstrated that patients hospitalized with the noninvasive enteric pathogen CS6-expressing ETEC responded with both mucosal and systemic antibodies against CS6. Studies are needed to determine if the anti-CS6 responses protect against reinfection and if protective levels of CS6 immunity are induced by vaccination.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?