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Disease burden due to enterotoxigenic Escherichia coli in the first 2 years of life in an urban community in Bangladesh.

Artikel i vetenskaplig tidskrift
Författare Firdausi Qadri
Amit Saha
Tanvir Ahmed
Abdullah Al Tarique
Yasmin Ara Begum
Ann-Mari Svennerholm
Publicerad i Infection and immunity
Volym 75
Nummer/häfte 8
Sidor 3961-8
ISSN 0019-9567
Publiceringsår 2007
Publicerad vid Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi
Sidor 3961-8
Språk en
Länkar dx.doi.org/10.1128/IAI.00459-07
Ämnesord ABO Blood-Group System, Bacterial Toxins, biosynthesis, Bangladesh, epidemiology, Breast Feeding, Diarrhea, Infantile, epidemiology, microbiology, Enterotoxins, biosynthesis, Enzyme-Linked Immunosorbent Assay, Escherichia coli, classification, isolation & purification, Escherichia coli Infections, blood, epidemiology, microbiology, pathology, Escherichia coli Proteins, biosynthesis, Feces, microbiology, Female, Humans, Incidence, Infant, Infant, Newborn, Male, Pregnancy, Rotavirus, isolation & purification, Rotavirus Infections, epidemiology, Seasons, Urban Population
Ämneskategorier Mikrobiologi inom det medicinska området

Sammanfattning

A cohort of 321 children was followed from birth up to 2 years of age to determine the incidence of enterotoxigenic Escherichia coli (ETEC) in Bangladesh. The average number of diarrheal days and incidence rates were 6.6 and 2.3/child/year, respectively. ETEC was the most common pathogen and was isolated in 19.5% cases, with an incidence of 0.5 episode/child/year. The prevalence of rotavirus diarrhea was lower (10%). ETEC expressing the heat-stable enterotoxin (ST) was predominant. Strains isolated from diarrheal cases were positive for colonization factors (CFs) in higher frequency (66%) than from healthy children (33%) (P < 0.001). The heat-labile toxin (LT)-positive strains from healthy children were more often CF negative (92%) than those isolated from children with diarrhea (73%) (P < 0.001). In children with symptomatic or asymptomatic infections by CFA/I, CS1 plus CS3, CS2 plus CS3, or CS5 plus CS6 strains, a repeat episode of diarrhea or infection by the homologous CF type was uncommon. Repeat symptomatic infections were noted mostly for LT- and ST-expressing ETEC. ETEC diarrhea was more prevalent in children in the A and AB groups than in those in the O blood group (P = 0.032 to 0.023). Children with ETEC diarrhea were underweight and growth stunted at the 2-year follow-up period, showing the importance of strategies to prevent and decrease ETEC diarrheal morbidity in children.

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