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Comparison of mucosal B- and T-cell responses in Helicobacter pylori-infected subjects in a developing and a developed country.

Artikel i vetenskaplig tidskrift
Författare Taufiqur Rahman Bhuiyan
Firdausi Qadri
Prodip Kumar Bardhan
Mian Mashhud Ahmad
Bert Kindlund
Ann-Mari Svennerholm
Anna Lundgren
Publicerad i FEMS immunology and medical microbiology
Volym 54
Nummer/häfte 1
Sidor 70-9
ISSN 0928-8244
Publiceringsår 2008
Publicerad vid Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi
Sidor 70-9
Språk en
Länkar dx.doi.org/10.1111/j.1574-695X.2008...
Ämnesord Adolescent, Adult, Animals, Antibodies, Bacterial, analysis, immunology, B-Lymphocytes, immunology, Bangladesh, epidemiology, Developed Countries, Developing Countries, Duodenum, immunology, Female, Helicobacter Infections, epidemiology, immunology, microbiology, Helicobacter pylori, immunology, Humans, Immunity, Mucosal, Intestinal Mucosa, immunology, Male, Middle Aged, Pyloric Antrum, immunology, Sweden, epidemiology, T-Lymphocytes, immunology
Ämneskategorier Mikrobiologi inom det medicinska området

Sammanfattning

Helicobacter pylori is highly endemic in developing countries, but comparatively little is known about mucosal immune responses to H. pylori in these settings. Therefore, we have compared B- and T-cell responses, with a focus on the gastrointestinal mucosa, in H. pylori-infected adults in a developing (Bangladesh) and a developed (Sweden) country. We found comparable numbers of CD19(+) B cells and CD4 (+)T cells and similar levels of H. pylori-specific IgA antibodies in gastric mucosa from Bangladeshi and Swedish volunteers. However, about threefold higher numbers of CD19(+) B cells and 12-fold increased levels of H. pylori-specific IgA antibodies were found in the duodenum of Bangladeshi subjects. The gastric and duodenal immune responses in Bangladeshi asymptomatic carriers and duodenal ulcer patients were comparable. Bangladeshi subjects had about twofold lower titers of H. pylori-specific IgA and IgG antibodies in the circulation compared with Swedish volunteers. In conclusion, our findings suggest that Bangladeshi individuals have comparable gastric immune responses, but lower systemic antibody responses to H. pylori, compared with Swedish volunteers. Increased inflammation is present in the duodenum of Bangladeshi volunteers, maybe as a result of frequent exposure to enteric infections in these individuals.

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