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The bone tissue responses to prehydrated and collagenated cortico-cancellous porcine bone grafts: a study in rabbit maxillary defects.

Artikel i vetenskaplig tidskrift
Författare Ulf Nannmark
Lars Sennerby
Publicerad i Clinical implant dentistry and related research
Volym 10
Nummer/häfte 4
Sidor 264-70
ISSN 1708-8208
Publiceringsår 2008
Publicerad vid Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi
Institutionen för kliniska vetenskaper
Sidor 264-70
Språk en
Länkar dx.doi.org/10.1111/j.1708-8208.2007...
Ämnesord Absorbable Implants, Animals, Bone Regeneration, Bone Transplantation, methods, physiology, Collagen, metabolism, Female, Guided Tissue Regeneration, Periodontal, Implants, Experimental, Maxilla, surgery, Rabbits, Swine
Ämneskategorier Biomaterial

Sammanfattning

BACKGROUND: Bone substitutes should have osteoconductive properties and be completely replaced with new bone with time. Adding collagen gel to prehydrated and collagenated porcine bone (PCPB) particles results in a sticky and moldable material which facilitates clinical handling. However, the possible influence of the gel on the bone tissue response is not known. PURPOSE: The objective of the study was to evaluate the bone tissue responses to PCPB graft with or without collagen gel and to evaluate the resorption/degradation properties of the biomaterials. MATERIALS AND METHODS: Fourteen rabbits were used in the study. Bilateral bone defects, 5 x 8 x 3 mm, were created in the maxilla and filled with PCPB + collagen gel (test) or with PCPB only (control) and covered with a collagen membrane. Animals were killed after 2 (n = 3), 4 (n = 3), and 8 weeks (n = 8) for histological and morphometrical evaluations. RESULTS: There were no differences between test and control defects. Both materials showed bone formation directly on the particles by typical osteoblastic seams. The bone area increased with time (2-8 weeks) for both sides, from 16.2% (control) and 19.2% (test) to 42.7 and 43.8%, respectively. The PCPB, whether mixed with collagen gel or not, was resorbed by osteoclasts as well as part of remodeling with the formation of osteons within the particles. Morphometry showed a decrease of PCPB area from 19.4% (control) and 23.8% (test) after 2 weeks to 3.7 and 9.3% after 8 weeks, respectively. CONCLUSIONS: Mixing collagen gel and PCPB to facilitate the clinical handling does not influence the bone tissue responses to the material, which exhibited osteoconductive properties and was resorbed with time.

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