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Expression patterns of the Tmem16 gene family during cephalic development in the mouse

Artikel i vetenskaplig tidskrift
Författare Amel Gritli Linde
Forugh Vazirisani
JK Rock
Kristina Hallberg
D Iribarne
Brian D Harfe
Anders Linde
Publicerad i Gene Expression Patterns
Volym 9
Nummer/häfte 3
Sidor 178-191
ISSN 1567-133X
Publiceringsår 2009
Publicerad vid Institutionen för odontologi
Sidor 178-191
Språk en
Länkar dx.doi.org/10.1016/j.gep.2008.11.00...
Ämnesord Anoctamin-1; Enamel knot; Blood vessels; Bone; Cartilage; Cochlea; Cranial nerve ganglia; Hyaloid plexus; Leptomeninges; Motor neurons; Neuroepithelium; Olfactory epithelium; Osteoblasts; Palate; Retina; Spinal cord; Striatum; Submandibular ganglion; Tongue; Tooth
Ämneskategorier Morfologi, Biokemi, Cell- och molekylärbiologi

Sammanfattning

Tmem16a, Tmem16c, Tmem16f, Tmem16h and Tmem16k belong to the newly identified Tmem16 gene family encoding eight-pass transmembrane proteins. We have analyzed the expression patterns of these genes during mouse cephalic development. In the central nervous system, Tmem16a transcripts were abundant in the ventricular neuroepithelium, whereas the other Tmem16 family members were readily detectable in the subventricular zone and differentiating fields. In the rostral spinal cord, Tmem16f expression was highest in the motor neuron area. In the developing eye, the highest amounts of Tmem16a transcripts were detected in the lens epithelium, hyaloid plexus and outer layer of the retina, while the other family members were abundant in the retinal ganglionic cell layer. Interestingly, throughout development, Tmem16a expression in the inner ear was robust and restricted to a subset of cells within the epithelium, which at later stages formed the organ of Corti. The stria vascularis was particularly rich in Tmem16a and Tmem16f mRNA. Other sites of Tmem16 expression included cranial nerve and dorsal root ganglia, meningeal precursors and the pituitary. Tmem16c and Tmem16f transcripts were also patent in the submandibular autonomic ganglia. A conspicuous feature of Tmem16a was its expression along the walls of blood vessels as well as in cells surrounding the trigeminal and olfactory nerve axons. In organs developing through epithelial-mesenchymal interactions, such as the palate, tooth and tongue, the above five Tmem16 family members showed interesting dynamic expression patterns as development proceeded. Finally and remarkably, osteoblasts and chondrocytes were particularly loaded with Tmem16a, Tmem16c and Tmem16f transcripts.

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