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The lean woman.

Artikel i vetenskaplig tidskrift
Författare Fariba Baghaei
Roland Rosmond
Lars Westberg
Monika Hellstrand
Mikael Landén
Elias Eriksson
Göran Holm
Per Björntorp
Publicerad i Obesity research
Volym 10
Nummer/häfte 2
Sidor 115-21
ISSN 1071-7323
Publiceringsår 2002
Publicerad vid Institutionen för fysiologi och farmakologi, Avdelningen för farmakologi
Institutionen för klinisk neurovetenskap, Sektionen för psykiatri
Institutionen för invärtesmedicin, Avdelningen för lungmedicin och allergologi
Sidor 115-21
Språk en
Länkar dx.doi.org/10.1038/oby.2002.18
Ämnesord Adult, Androgens, blood, Aromatase, genetics, Body Constitution, Body Mass Index, Dehydroepiandrosterone Sulfate, blood, Educational Status, Estradiol, blood, Exercise, Female, Health Status, Humans, Hydrocortisone, analysis, Insulin-Like Growth Factor I, analysis, Mental Health, Microsatellite Repeats, Premenopause, Risk Factors, Saliva, chemistry, Smoking, epidemiology, Socioeconomic Factors, Sports, Thyroid Hormones, blood
Ämneskategorier Farmakologi och toxikologi

Sammanfattning

OBJECTIVE: In the current obesity epidemic, the ability to remain lean is beginning to be uncommon. Therefore, it was considered of interest to characterize such subjects. RESEARCH METHODS AND PROCEDURES: From a population of premenopausal women (n = 270), all 40 years of age, those with a similar body mass index (BMI) as women at the age of 21 years, born the same year (BMI = 21.1 kg/m(2)) were selected among nonsmokers and compared with the remaining nonsmoking women. RESULTS: Lean women showed, as expected, low waist-to-hip circumference ratio and abdominal sagittal diameter as well as absence of other disease risk factors. Compared with the remaining women, 17 beta-estradiol was high and androgens were low, whereas insulin-like growth factor I and thyroid hormones showed no differences. Dihydroepiandrosterone sulfate was lower, whereas cortisol, measured in saliva repeatedly over a day, and adrenocorticotropin hormone were not different. Results from questionnaires indicated higher education and socioeconomic status, frequent sports activities, and better psychosocial adaptation and psychological health. A tetranucleotide repeat polymorphism in the fourth [corrected] intron of the aromatase P450 gene was longer among the lean (187 base pairs) than the rest of the women. Women with opposite phylogenetic characteristic have a short microsatellite (168 base pairs) in this gene locus. DISCUSSION: Lean, nonsmoking women enjoy an excellent health in not only anthropometric and metabolic factors, but also in neuroendocrine, endocrine, and psychological variables. The endocrine measurements suggest a well-functioning aromatase, which in turn might have a genetic background, contributing to health. The aromatase gene might be important for regulation of body fat mass.

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