Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Associations between pers… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Associations between personality traits and polymorphisms in genes related to inflammation in women

Poster (konferens)
Författare Petra Suchankova
Susanne Henningsson
Fariba Baghaei
Roland Rosmond
Göran Holm
Elias Eriksson
Agneta Ekman
Publicerad i 49th Annual meeting of the Scandinavian College of Neuro-Psychopharmacology
Publiceringsår 2008
Publicerad vid Institutionen för medicin
Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi
Institutionen för medicin, avdelningen för molekylär och klinisk medicin
Språk en
Ämneskategorier Medicinsk genetik

Sammanfattning

Both inflammation and certain personality traits have been associated with depression; however, the mechanisms underlying these connections are unknown. The present study investigates two single nucleotide polymorphisms located in genes that are associated with inflammation with regards to personality traits in order to examine the possible involvement of inflammation in general brain functions. The first polymorphism, +1444C>T (rs1130864), is located in the gene coding for C-reactive protein (CRP), a marker of low-grade inflammation, and has previously been linked to raised serum levels of high-sensitivity CRP. The second polymorphism, Y402H (rs1061170), is located in the gene coding for complement factor H (CFH), an important regulator of the complement system. CRP binds to CFH and thereby augments the ability of CFH to down regulate the alternative pathway of complement. The 402H allele has consistently been associated with age-related macular degeneration and was recently linked to Alzheimer’s disease. The population consisted of 270 women recruited from the population registry. These women were assessed by means of Karolinska Scale of Personality, a self-reported inventory. The +1444T allele was significantly associated with higher scores in the personality traits impulsiveness, monotony avoidance and social desirability (p=0.0016, p=0.016 and p=0.048, respectively). The 402H polymorphism was significantly associated with higher levels of the personality trait verbal aggression (p=0.008). In conclusion, the association between the studied CRP and CFH polymorphisms and personality traits further supports the association between the immune system and mental functions.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?