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Abnormal vessel morphology in boys born after intracytoplasmic sperm injection.

Artikel i vetenskaplig tidskrift
Författare Margareta Hök Wikstrand
Aimon Niklasson
Kerstin Strömland
Ann Hellström
Publicerad i Acta paediatrica (Oslo, Norway : 1992)
Volym 97
Nummer/häfte 11
Sidor 1512-7
ISSN 1651-2227
Publiceringsår 2008
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering
Institutionen för kliniska vetenskaper
Sidor 1512-7
Språk en
Länkar dx.doi.org/10.1111/j.1651-2227.2008...
Ämneskategorier Medicin och Hälsovetenskap

Sammanfattning

AIM: Children born after intracytoplasmic sperm injection (ICSI) are at risk of preterm birth, low birth weight and perinatal morbidity which may predispose for diseases of the central nervous and vascular systems. Our aim was to investigate the ocular fundus morphology in children born after ICSI. METHOD: Children born after ICSI (n = 82) had ocular fundus photographs taken at the age of 5 years and results were compared with those of a control group (n = 203). The ocular fundus morphology with the central retinal vessels was evaluated by digital image analysis. RESULTS: Children born after ICSI (n = 57) had abnormal retinal vascularization as evidenced by a lower number of vascular branching points compared with the control group (n = 181) (p = 0.0002). A gender difference was found whereby the ICSI boys (n = 35) had significantly fewer retinal branching points (median 24, range 19-29.5) compared with the control boys (median 27.5, range 20-37) (p < 0.0001). CONCLUSION: Our findings showed that ICSI boys have abnormal vessel morphology as demonstrated by a reduced number of central retinal branching points. The difference still remained after elimination of factors earlier shown to be associated with a low number of vascular branching points, i.e. low birth weight and preterm, suggesting other mechanisms responsible for the low number of vascular branching points.

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