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Dietary n-6:n-3 fatty acid ratio in the perinatal period affects bone parameters in adult female rats.

Artikel i vetenskaplig tidskrift
Författare Marina Korotkova
Claes Ohlsson
Lars Åke Hanson
Birgitta Strandvik
Publicerad i The British journal of nutrition
Volym 92
Nummer/häfte 4
Sidor 643-8
ISSN 0007-1145
Publiceringsår 2004
Publicerad vid Institutionen för invärtesmedicin, Avdelningen för internmedicin
Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik
Sidor 643-8
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Animals, Body Weight, drug effects, Bone Density, drug effects, Bone Development, drug effects, Diet, Dietary Fats, Unsaturated, administration & dosage, pharmacology, Fatty Acids, Omega-3, administration & dosage, analysis, pharmacology, Fatty Acids, Omega-6, administration & dosage, analysis, pharmacology, Female, Femur, growth & development, Insulin-Like Growth Factor I, analysis, Phospholipids, blood, chemistry, Pregnancy, Prenatal Exposure Delayed Effects, Prenatal Nutrition Physiology, physiology, Rats, Rats, Sprague-Dawley
Ämneskategorier Medicin och Hälsovetenskap

Sammanfattning

PUFA and their metabolites are important regulators of bone formation and resorption. The effect of PUFA on bone growth may be especially striking during the perinatal period. The aim of the present study was to investigate the effect of diets with different n-6:n-3 fatty acid (FA) ratios during the perinatal period on bone parameters in the adult offspring. During late gestation and throughout lactation, rat dams were fed an isoenergetic diet containing 70 g linseed oil (n-3 diet), soyabean oil (n-6+n-3 diet) or sunflower-seed oil (n-6 diet) per kg with n-6:n-3 FA ratios of 0.4, 9 and 216, respectively. The offspring were weaned onto an ordinary chow and followed until 30 weeks of age. Bone parameters were analysed using peripheral quantitative computerised tomography and dual-energy X-ray absorptiometry. Femur length and cortical cross-sectional bone area and bone mineral content were significantly higher in the n-6+n-3 group than in the other groups. Cortical bone thickness in the n-6+n-3 group was increased compared with the n-3 group, but most cortical bone parameters did not differ between the n-3 and n-6 groups. The results suggest that regulatory mechanisms were influenced by the n-6:n-3 FA ratio early in life and not compensated for by the introduction of an ordinary diet after weaning.

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